Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Preventing Civil War in Iraq: A News Hour with Jim Lehrer Transcript with Jim Lehrer, Vali Nasr, and Thabit Abdullah; Strategic Insights, v. 5, issue 3 (March 2006)

This article appeared in Strategic Insights, v.5, issue 3 (March 2006)Approved for public release; distribution is unlimited

KNPR interview

Veteran PBS News Anchor Jim Lehrer will be leading a panel at Black Mountain Institute on Wednesday. He joins us to talk about the changes in the news business ahead of the discussion at UNLV

The Death of old news

Jim Lehrer is the author of two memoirs, three plays, and 20 novels, including Super, Flying Crows, and The Phony Marine, as well as a series featuring a fictional lieutenant governor of Oklahoma. He has been honored with numerous awards for journalism, including the 1999 National Humanities Medal, two Emmys, the Fred Friendly First Amendment Award, the George Foster Peabody Broadcast Award, the William Allen White Foundation Award for Journalistic Merit, and the University of Missouri School of Journalism\u27s Medal of Honor. In 1991, he was elected a Fellow of the American Academy of Arts and Sciences. He is currently the executive editor and anchor of The NewsHour with Jim Lehrer on PBS. Alex Jones is the Laurence M. Lombard Lecturer in the Press and Public Policy and director of the Joan Shorenstein Center on the Press, Politics, and Public Policy at Harvard. He co-authored The Patriarch: The Rise and Fall of the Bingham Dynasty and The Trust: The Private and Powerful Family Behind The New York Times. He has been a Nieman Fellow at Harvard, a host of National Public Radio\u27s On the Media, and host and executive editor of PBS\u27s Media Matters. He is on the boards of the Committee of Concerned Journalists, International Center for Journalists, Foundation of the Society of Professional Journalists, Harvard Magazine, Nieman Foundation, Black Mountain Institute, the Institute for Politics, Democracy & the Internet, and other professional organizations. He covered the press for The New York Times from 1983-92 and was awarded the Pulitzer Prize in 1987

Congressman Trent Lott on Newshour

Congressman Trent Lott\u27s appearance on Newshour with host Jim Lehrer and Congressman Leon Panetta. Topics discussed include: debt reduction, tax reform, defense spending, and the national budget

Bargaining and reputation: An experiment on bargaining in the presence of behavioral types

Abstract We conduct a series of laboratory experiments to understand what role commitment and reputation play in bargaining. The experiments implement th