Joint estimation of multiple related biological networks

Graphical models are widely used to make inferences concerning interplay in multivariate systems. In many applications, data are collected from multiple related but nonidentical units whose underlying networks may differ but are likely to share features. Here we present a hierarchical Bayesian formulation for joint estimation of multiple networks in this nonidentically distributed setting. The approach is general: given a suitable class of graphical models, it uses an exchangeability assumption on networks to provide a corresponding joint formulation. Motivated by emerging experimental designs in molecular biology, we focus on time-course data with interventions, using dynamic Bayesian networks as the graphical models. We introduce a computationally efficient, deterministic algorithm for exact joint inference in this setting. We provide an upper bound on the gains that joint estimation offers relative to separate estimation for each network and empirical results that support and extend the theory, including an extensive simulation study and an application to proteomic data from human cancer cell lines. Finally, we describe approximations that are still more computationally efficient than the exact algorithm and that also demonstrate good empirical performance.Comment: Published in at http://dx.doi.org/10.1214/14-AOAS761 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Citations Only in Your IR: The End of the IR as We Know It or the Shape of Things to Come?

Institutional Repositories were conceived to collect and disseminate the intellectual output of the organizations that sponsor them. That output is full content of some form—text, graphics, multimedia, datasets, and more. As IRs have evolved, however, the possibility of quickly and easily populating it with just citations without the actual content has gained attention. The choice of requiring full content or allowing citation only is a question not without controversy. This presentation will examine the issues involved with both ideas and discuss advantages and disadvantages of each

Handbook of Nonsexist Writing for Writers, Editors and Speakers; Marketing to Women ; Microcomputer Primer (First Edition): A Layman\u27s Guide for Selection and Use of Microcomputers in Developing Countries

Reviews of The Handbook of Nonsexist Writing for Writers, Editors and Speakers by Casey Miller and Kate Swift; Marketing to Women, by Cecelia Reed, Mark Sullivan and Neal Hirschfeld; and Microcomputer Primer (First Edition): A Layman\u27s Guide for Selection and Use of Microcomputers in Developing Countries, by John L. Woods

South Dublin County Profile (NIRSA) Working Paper Series. No. 14

The main objective of this report is to provide a comprehensive assessment of the current situation in order to assist South Dublin County Development Board in the preparation of its strategy for economic, social and cultural development over the next ten years. The city and environs of Dublin now extend over a very extensive area, exceeding the boundaries of the Dublin administrative units. It represents a complex and dynamic functional entity with roles as both the national capital and the principal international gateway for the country. Since the mid 1990s the old county Dublin has been divided into four units for purposes of public administration, within each of which a City/County Development Board was established in 1999. As each Board is required to prepare a strategy for economic, social and cultural development, the approach adopted here is to provide an analysis that takes account of the wider context while also providing detailed small area analysis for the wards/DEDs of the CDB area

System for creating at a site, remote from a sterile environment, a parenteral solution

The present invention relates to a container, system, and method for creating parenteral solutions at a site, remote from sterile environments. The system includes a flexible container that is empty except for a prepackaged amount of a solute that is housed in the interior of the container. The container includes at least one port and a sterilizing filter in communication with an interior of the port. The container is so constructed and arranged that a fluid flow path is created from the port through the filter and into the interior of the container. A sterile water source including means for establishing fluid flow from the sterile water source into the port is provided. Accordingly, sterile water can flow from the sterile water source through the filter into the container where it is mixed with the solute to create a parenteral solution that can then be infused into a patient. A method and container are also provided

Project APEX: Advanced manned exploration of the Martian moon Phobos

A preliminary design has been developed for a manned mission to the Martian moon Phobos. The spacecraft is to carry a crew of five and will be launched from Low Earth Orbit in the year 2010. The outbound trajectory to Mars uses a gravitational assisted swingby of Venus and takes eight months to complete. The stay at Phobos is scheduled for 60 days. During this time, the crew will be busily engaged in setting up a prototype fuel processing facility. The vehicle will then return to Earth orbit after a total mission duration of 656 days. The spacecraft is powered by three nuclear thermal rockets which also provide the primary electrical power via dual mode operation. The overall spacecraft length is 110 m, and the total mass departing from Low Earth Orbit is 900 metric tons