Jaw osteonecrosis management around a dental implant inserted 2 years before starting treatment with zoledronic acid

Bisphosphonates (BP) are a type of drug known to inhibit bone resorption through complex interventions. Their primary mechanism of action is aimed at the cellular level, inhibiting osteoclast activity and so bone resorption. BPs are widely used, with many patients receiving continuous treatment for years. But it is well known that these drugs can produce osteonecrosis of the jaw (ONJ). Zoledronic acid (ZA) is an intravenous BP used in the treatment and prophylaxis of bone disease in patients with malignant tumors with bone implication. ZA is the most potent BP in clinical development. This report describes the case of a 62-year-old woman with breast cancer antecedents which relapsed, who had received a maxillary dental implant two years before the start of therapy with zoledronic acid. She later developed osteonecrosis of the jaw (ONJ), which began in the peri-implant area, and was treated for stage 3 ONJ by sub-total maxillectom

Jaw osteonecrosis management around a dental implant inserted 2 years before starting treatment with zoledronic acid

Journal Article;Bisphosphonates (BP) are a type of drug known to inhibit bone resorption through complex interventions. Their primary mechanism of action is aimed at the cellular level, inhibiting osteoclast activity and so bone resorption. BPs are widely used, with many patients receiving continuous treatment for years. But it is well known that these drugs can produce osteonecrosis of the jaw (ONJ). Zoledronic acid (ZA) is an intravenous BP used in the treatment and prophylaxis of bone disease in patients with malignant tumors with bone implication. ZA is the most potent BP in clinical development. This report describes the case of a 62-year-old woman with breast cancer antecedents which relapsed, who had received a maxillary dental implant two years before the start of therapy with zoledronic acid. She later developed osteonecrosis of the jaw (ONJ), which began in the peri-implant area, and was treated for stage 3 ONJ by sub-total maxillectomy. Key words:Bisphosphonates, zoledronic acid, osteonecrosis of the jaw, peri-implantitis, maxillectomy.Ye

Tratamiento quirúrgico de las malposiciones dentales

We present the results obtained during our 17 years of experience in surgical treatment of dental malpositions. We include the autotransplantation of embedded molars, autotransplantation of retained canines and the repositioning of malpositioned incisors, canines and premolars; A total of 81 teeth, 60 autotransplanted and 21 repositioned, with a large degree of success. Detailed explanation is given regarding the surgical indications, techniques and results. In view of this, a conclusion is reached regarding the high, long-term success rate of surgical manipulation of embedded, healthy teeth.Presentamos los resultados obtenidos tras 17 años de experiencia en el tratamiento quirúrgico de las malposiciones dentales. Se incluyen los autotrasplantes de molares incluidos, autotrasplantes de caninos retenidos y reubicación de incisivos, caninos o premolares mal posicionados; 81 piezas dentales en total, de los cuales 60 dientes corresponden a autotrasplantes y 21 a reubicaciones, obteniendo un alto porcentaje de éxito. Se explica en detalle las indicaciones, técnica quirúrgica y resultados, concluyendo en que a la vista de los mismos, la manipulación quirúrgica de dientes retenidos sanos tiene un alto porcentaje de éxito a largo plazo