Localization Transformation of Five Coordinate Milling Machine

AbstractAs five coordinates gantry milling machine is not able to meet the requirements of the parts of precision and efficient processing, for the machine tool's electrical function degradation, mechanical part aging, CNC system backward, now it needs to upgrade the whole electrification and fix the mechanical part by Huangzhong, HNC - 848 c/M bus type numerical control system. Though the machine localization reformation, the precision and efficiency of the machine tool are improved, thus the application of domestic CNC system and functional components in the machine tool are promoted

Synergistic effect of self-assembled carbon nanopaper and multi-layered interface on shape memory nanocomposite for high speed electrical actuation

The synergistic effect of self-assembled carbon nanofiber (CNF) nanopaper and the multi-layered interface on the electrical properties and electro-activated recovery behavior of shape memory polymer (SMP) nanocomposites is investigated. The CNFs were self-assembled by deposition into sheets of multi-layered nanopaper form to significantly enhance the bonding strength between the nanopaper and SMP via van der Waals force. The self-assembled multi-layered CNF nanopaper resulted in improved electrical conductivity and temperature distribution in the SMP nanocomposites. This not only significantly enhances the reliability of bonding between the nanopaper and the SMP, resulting in an improved recovery ratio, but also provides high speed electrical actuation

Вихретоковый анизотропный термоэлектрический первичный преобразователь лучистого потока

Представлена оригинальная конструкция первичного преобразователя лучистого потока, который может служить основой для создания приемника неселективного излучения с повышенной чувствительностью

Genome-Wide Association Study of Lung Adenocarcinoma in East Asia and Comparison With a European Population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction  = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Phantom Study on the Influence of CT Model and Tube Voltage on Image Quality

Objective: To compare the image quality between two CT scanners under two different tube voltages using a dedicated phantom. Materials and Methods: Siemens SOMATOM Force CT and Phillips Spectral IQon CT were used for scanning and the dedicated Assurance Quality Phantom Catphan 500 was applied. Module CTP 528 and CTP 515 were performed for evaluation of high resolution and low-contrast sensitivity, respectively. Four sets of images of two scanners were acquired, including group A to D whic represented force 120 kVp, force 140 kVp, IQon 120 kVp and IQon 140 kVp. The dosage of all four set of images was 20mGy.Evaluation of high resolution was carried out by two radiologists via the smallest line pair one could distinguish and low-contrast sensitivity was measured by the smallest diameter under 1% contrast. Mean noise, signal-to -oise ratio (SNR) and contrast-to-noise ratio (CNR) were also evaluated for each group. Results: Group A and C had the highest high resolution with a line pair of 6 lp/cm; the same low-contrast sensitivity was observed by all the groups (diameter of 5 mm). Group A showed the smallest noise (2.500±0.000) and highest SNR (30.806±1.398). Noise and SNR were both significantly different among four groups. The highest CNR (3.325±0.300) was observed in Group D, but no statistical difference was found among the four groups. Conclusion: Image quality varied under different CT scanners and tube voltages. Images with 120 kVp showed better contrast compared with those with 140 kVp. 120 kVp with force CT showed improved image noise than that of 140 kVp images; while for IQon spectral CT, no obvious difference in noise parameters was found between the two tube voltages

Site Selection of Affordable Housing in Direct Management Area under Jiangbei’s New District in Nanjing

Affordable housing is an effective approach for relieving the residential stress of moderate and low-income citizens; it is not only a macro study but also a micro one in the processive phase focusing on site selection and so on. From this view, the site selection of affordable housing in the direct management district under Jiangbei New District in Nanjing is analyzed, including summarizing the status quo and construction models of affordable housing’s site selection; quantifying the influential elements of site selection by the AHP method and GIS spatial analysis. The final result shows that the site of Jiangbei’s new district in Nanjing, with a score ranging from 2.7792 to 3.8572, is recommended for affordable housing. According to this result, the optimization strategy of affordable housing planning and location is put forward to ensure the balance of work and housing and the interests of low-income groups