sj-docx-3-cpc-10.1177_10556656221125392 - Supplemental material for <i>MMP16</i> as NSCL ± P Susceptible Gene in Western Han Chinese

Supplemental material, sj-docx-3-cpc-10.1177_10556656221125392 for MMP16 as NSCL ± P Susceptible Gene in Western Han Chinese by Yansong Lin, Jiayu Shi, Bing Shi and Zhonglin Jia in The Cleft Palate-Craniofacial Journal</p

sj-docx-5-cpc-10.1177_10556656221125392 - Supplemental material for <i>MMP16</i> as NSCL ± P Susceptible Gene in Western Han Chinese

Supplemental material, sj-docx-5-cpc-10.1177_10556656221125392 for MMP16 as NSCL ± P Susceptible Gene in Western Han Chinese by Yansong Lin, Jiayu Shi, Bing Shi and Zhonglin Jia in The Cleft Palate-Craniofacial Journal</p

sj-tif-1-cpc-10.1177_10556656221125392 - Supplemental material for <i>MMP16</i> as NSCL ± P Susceptible Gene in Western Han Chinese

Supplemental material, sj-tif-1-cpc-10.1177_10556656221125392 for MMP16 as NSCL ± P Susceptible Gene in Western Han Chinese by Yansong Lin, Jiayu Shi, Bing Shi and Zhonglin Jia in The Cleft Palate-Craniofacial Journal</p

sj-docx-4-cpc-10.1177_10556656221125392 - Supplemental material for <i>MMP16</i> as NSCL ± P Susceptible Gene in Western Han Chinese

Supplemental material, sj-docx-4-cpc-10.1177_10556656221125392 for MMP16 as NSCL ± P Susceptible Gene in Western Han Chinese by Yansong Lin, Jiayu Shi, Bing Shi and Zhonglin Jia in The Cleft Palate-Craniofacial Journal</p

sj-tif-2-cpc-10.1177_10556656221125392 - Supplemental material for <i>MMP16</i> as NSCL ± P Susceptible Gene in Western Han Chinese

Supplemental material, sj-tif-2-cpc-10.1177_10556656221125392 for MMP16 as NSCL ± P Susceptible Gene in Western Han Chinese by Yansong Lin, Jiayu Shi, Bing Shi and Zhonglin Jia in The Cleft Palate-Craniofacial Journal</p

Table3_FOXC2 as a prognostic marker and a potential molecular target in patients with human solid tumors.docx

BackgroundForkhead Box Protein C2 (FOXC2) belongs to the Forkhead/Wing-helix family. The regulatory role of this transcription factor in physiological function and carcinogenic activity has been proven in subsequent investigations. However, there is still scarcity of evidence on the relationship between FOXC2 expression and prognosis in human solid tumors. We conducted this meta-analysis to evaluate the role of FOXC2 as a prognosis factor and a possible target marker in human solid tumors.MethodsPubMed, Web of Science, Embase, and the Cochrane library database were all searched methodically. Eligible publications on FOXC2 in human solid tumors were gathered and reviewed. The effect sizes were calculated using pooled hazard ratios (HRs) or odds ratios (ORs) with the corresponding 95% confidence interval (CI). Statistical analysis was conducted with Stata SE12.0.ResultsThis meta-analysis comprised 3,267 patients from 20 studies covering a variety of solid tumors. Increased FOXC2 expression was related to shorter overall survival (OS) (HR = 2.05, 95% CI: 1.73–2.42). High expression of FOXC2 is associated with lymph node metastases (OR = 3.33, 95% CI: 2.65–4.19), TNM stage (OR = 3.09, 95% CI: 2.00–4.78), and age (OR = 1.26, 95% CI: 1.06–1.50), according to the pooled ORs. However, no significant association was observed between the high expression of FOXC2 and sex, tumor size or tumor differentiation.ConclusionIncreased expression of FOXC2 is associated with unfavored OS, lymph node metastases, TNM stage, and age. FOXC2 is a promising prognostic marker and a novel target marker in human solid tumors.</p

Table1_FOXC2 as a prognostic marker and a potential molecular target in patients with human solid tumors.doc

BackgroundForkhead Box Protein C2 (FOXC2) belongs to the Forkhead/Wing-helix family. The regulatory role of this transcription factor in physiological function and carcinogenic activity has been proven in subsequent investigations. However, there is still scarcity of evidence on the relationship between FOXC2 expression and prognosis in human solid tumors. We conducted this meta-analysis to evaluate the role of FOXC2 as a prognosis factor and a possible target marker in human solid tumors.MethodsPubMed, Web of Science, Embase, and the Cochrane library database were all searched methodically. Eligible publications on FOXC2 in human solid tumors were gathered and reviewed. The effect sizes were calculated using pooled hazard ratios (HRs) or odds ratios (ORs) with the corresponding 95% confidence interval (CI). Statistical analysis was conducted with Stata SE12.0.ResultsThis meta-analysis comprised 3,267 patients from 20 studies covering a variety of solid tumors. Increased FOXC2 expression was related to shorter overall survival (OS) (HR = 2.05, 95% CI: 1.73–2.42). High expression of FOXC2 is associated with lymph node metastases (OR = 3.33, 95% CI: 2.65–4.19), TNM stage (OR = 3.09, 95% CI: 2.00–4.78), and age (OR = 1.26, 95% CI: 1.06–1.50), according to the pooled ORs. However, no significant association was observed between the high expression of FOXC2 and sex, tumor size or tumor differentiation.ConclusionIncreased expression of FOXC2 is associated with unfavored OS, lymph node metastases, TNM stage, and age. FOXC2 is a promising prognostic marker and a novel target marker in human solid tumors.</p

Table2_FOXC2 as a prognostic marker and a potential molecular target in patients with human solid tumors.docx

BackgroundForkhead Box Protein C2 (FOXC2) belongs to the Forkhead/Wing-helix family. The regulatory role of this transcription factor in physiological function and carcinogenic activity has been proven in subsequent investigations. However, there is still scarcity of evidence on the relationship between FOXC2 expression and prognosis in human solid tumors. We conducted this meta-analysis to evaluate the role of FOXC2 as a prognosis factor and a possible target marker in human solid tumors.MethodsPubMed, Web of Science, Embase, and the Cochrane library database were all searched methodically. Eligible publications on FOXC2 in human solid tumors were gathered and reviewed. The effect sizes were calculated using pooled hazard ratios (HRs) or odds ratios (ORs) with the corresponding 95% confidence interval (CI). Statistical analysis was conducted with Stata SE12.0.ResultsThis meta-analysis comprised 3,267 patients from 20 studies covering a variety of solid tumors. Increased FOXC2 expression was related to shorter overall survival (OS) (HR = 2.05, 95% CI: 1.73–2.42). High expression of FOXC2 is associated with lymph node metastases (OR = 3.33, 95% CI: 2.65–4.19), TNM stage (OR = 3.09, 95% CI: 2.00–4.78), and age (OR = 1.26, 95% CI: 1.06–1.50), according to the pooled ORs. However, no significant association was observed between the high expression of FOXC2 and sex, tumor size or tumor differentiation.ConclusionIncreased expression of FOXC2 is associated with unfavored OS, lymph node metastases, TNM stage, and age. FOXC2 is a promising prognostic marker and a novel target marker in human solid tumors.</p

Room-Temperature Lateral Spin Valve in Graphene/Fe₃GaTe₂ van der Waals Heterostructures

The remarkable electronic properties of two-dimensional van der Waals (vdW) materials make them promising platforms for next-generation spintronic devices. In this study, we demonstrate the room-temperature graphene lateral spin valve devices in the Fe3GaTe2/graphene full vdW heterostructure. The spin transport channel is few-layer graphene, and room-temperature ferromagnet Fe3GaTe2 is used as both the spin injector and detector. Pronounced nonlocal spin valve signals can be observed when the magnetic field sweeps along the out-of-plane easy axis direction of Fe3GaTe2. This nonlocal spin valve signal persists even at 320 K, realizing a room-temperature lateral spin valve in full vdW heterostructure. Additionally, a significant magnitude nonlocal spin valve signal can be detected even with the low bias current of 1 μA. Furthermore, the magnetic field angle-dependent nonlocal measurements revealed that the nonlocal spin valve behavior is closely related to the robust large perpendicular magnetic anisotropy property of Fe3GaTe2. The nonlocal spin valve signal is prominent when the magnetic field is applied near the perpendicular direction and disappears under the in-plane magnetic field. These results demonstrate the potential of Fe3GaTe2 as a prospective candidate for constructing room-temperature, two-dimensional vdW spintronic devices