TeCH: Text-guided Reconstruction of Lifelike Clothed Humans

Despite recent research advancements in reconstructing clothed humans from a single image, accurately restoring the "unseen regions" with high-level details remains an unsolved challenge that lacks attention. Existing methods often generate overly smooth back-side surfaces with a blurry texture. But how to effectively capture all visual attributes of an individual from a single image, which are sufficient to reconstruct unseen areas (e.g., the back view)? Motivated by the power of foundation models, TeCH reconstructs the 3D human by leveraging 1) descriptive text prompts (e.g., garments, colors, hairstyles) which are automatically generated via a garment parsing model and Visual Question Answering (VQA), 2) a personalized fine-tuned Text-to-Image diffusion model (T2I) which learns the "indescribable" appearance. To represent high-resolution 3D clothed humans at an affordable cost, we propose a hybrid 3D representation based on DMTet, which consists of an explicit body shape grid and an implicit distance field. Guided by the descriptive prompts + personalized T2I diffusion model, the geometry and texture of the 3D humans are optimized through multi-view Score Distillation Sampling (SDS) and reconstruction losses based on the original observation. TeCH produces high-fidelity 3D clothed humans with consistent & delicate texture, and detailed full-body geometry. Quantitative and qualitative experiments demonstrate that TeCH outperforms the state-of-the-art methods in terms of reconstruction accuracy and rendering quality. The code will be publicly available for research purposes at https://huangyangyi.github.io/TeCHComment: Project: https://huangyangyi.github.io/TeCH, Code: https://github.com/huangyangyi/TeC

Multiscale 3D genome organization underlies duck fatty liver with no adipose inflammation or serious injury

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease. Little is known about how gene expression and chromatin structure are regulated in NAFLD due to lack of suitable model. Ducks naturally develop fatty liver similar to serious human non-alcoholic fatty liver (NAFL) without adipose inflammation and liver fibrosis, thus serves as a good model for investigating molecular mechanisms of adipose metabolism and anti-inflammation. Here, we constructed a NAFLD model without adipose inflammation and liver fibrosis in ducks. By performing dynamic pathological and transcriptomic analyses, we identified critical genes involving in regulation of the NF-κB and MHCII signaling, which usually lead to adipose inflammation and liver fibrosis. We further generated dynamic three-dimensional chromatin maps during liver fatty formation and recovery. This showed that ducks enlarged hepatocyte cell nuclei to reduce inter-chromosomal interaction, decompress chromatin structure, and alter strength of intra-TAD and loop interactions during fatty liver formation. These changes partially contributed to the tight control the NF-κB and the MHCII signaling. Our analysis uncovers duck chromatin reorganization might be advantageous to maintain liver regenerative capacity and reduce adipose inflammation. These findings shed light on new strategies for NAFLD control.</p

A new chromosome-scale duck genome shows a major histocompatibility complex with several expanded multigene families

BACKGROUND: The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A virus (IAV), harbors almost all subtypes of IAVs and resists to many IAVs which cause extreme virulence in chicken and human. However, the response of duck's adaptive immune system to IAV infection is poorly characterized due to lack of a detailed gene map of the major histocompatibility complex (MHC).RESULTS: We herein reported a chromosome-scale Beijing duck assembly by integrating Nanopore, Bionano, and Hi-C data. This new reference genome SKLA1.0 covers 40 chromosomes, improves the contig N50 of the previous duck assembly with highest contiguity (ZJU1.0) of more than a 5.79-fold, surpasses the chicken and zebra finch references in sequence contiguity and contains a complete genomic map of the MHC. Our 3D MHC genomic map demonstrated that gene family arrangement in this region was primordial; however, families such as AnplMHCI, AnplMHCIIβ, AnplDMB, NKRL (NK cell receptor-like genes) and BTN underwent gene expansion events making this area complex. These gene families are distributed in two TADs and genes sharing the same TAD may work in a co-regulated model.CONCLUSIONS: These observations supported the hypothesis that duck's adaptive immunity had been optimized with expanded and diversified key immune genes which might help duck to combat influenza virus. This work provided a high-quality Beijing duck genome for biological research and shed light on new strategies for AIV control.</p

ON RECURRENT EVENT DATA ANALYSIS AND DEGRADATION TEST PLANNING: NOVEL STATISTICAL METHODS IN RELIABILITY

Ph.DDOCTOR OF PHILOSOPHY (FOE

Optimal Design of Accelerated Destructive Degradation Tests with Block Effects

10.1080/24725854.2020.1849875IISE Transactions54173-9

Assessing the Effect of Repair Delays on a Repairable System

10.1080/00224065.2019.1611347Journal of Quality Technology523293-30

Factorial design analytics on effects of material parameter uncertainties in multiphysics modeling of additive manufacturing

Abstract A bottleneck in Laser Powder Bed Fusion (L-PBF) metal additive manufacturing (AM) is the quality inconsistency of its products. To address this issue without costly experimentation, computational multi-physics modeling has been used, but the effectiveness is limited by parameter uncertainties and their interactions. We propose a full factorial design and variable selection approach for the analytics of main and interaction effects arising from material parameter uncertainties in multi-physics models. Data is collected from high-fidelity thermal-fluid simulations based on a 2-level full factorial design for 5 selected material parameters. Crucial physical phenomena of the L-PBF process are analyzed to extract physics-based domain knowledge, which are used to establish a validation checkpoint for our study. Initial data visualization with half-normal probability plots, interaction plots and standard deviation plots, is used to assess if the checkpoint is being met. We then apply the combination of best subset selection and the LASSO method on multiple linear regression models for comprehensive variable selection. Analytics yield statistically and phyiscally validated findings with practical implications, emphasizing the importance of parameter interactions under uncertainty, and their relation to the underlying physics of L-PBF

Can Tourism Development Help Improve Urban Liveability? An Examination of the Chinese Case

The emergence of &ldquo;urban diseases&rdquo; has aroused people&rsquo;s widespread concern about urban liveability. Therefore, it is worth studying whether tourism, as a &ldquo;smokeless industry&rdquo; can improve it. In this article, the benchmark model, the spatial Durbin model (SDM), and the panel threshold model (PTM) are constructed to test the impact of tourism development on urban liveability based on the data from 284 prefecture-level and above cities in China for the period 2004&ndash;2019. The results show that tourism development can significantly contribute to the improvement of urban liveability. Meanwhile, the positive impact of tourism development on the liveability of neighboring cities through spatial spillover effects is still valid in eastern, central, and western China, but the effect is much larger in the eastern and central cities than in the western cities. Moreover, tourism development has positive nonlinear effects on urban liveability, and the marginal effects are clearly decreasing after crossing the first and second thresholds. Finally, specific recommendations are proposed for tourism development to improve urban liveability