trans-4,5-Dihydr­oxy-1,3-bis­(4-methoxy­phen­yl)imidazolidine-2-thione

In the title compound, C17H18N2O4S, where one of the N-4-methoxy­phenyl fragments is disordered over two sets of sites, the five-membered ring exhibits a nearly half-chair conformation and the two hydroxyl groups lie on opposite sides of the five-membered ring. In the crystal, the mol­ecules are linked into sheets parallel to (100) via O—H⋯O and O—H⋯S hydrogen bonds

Dimethyl 2,6-dimethyl-1,4-dihydro­pyridine-3,5-dicarboxyl­ate

In the crystal of the title compound, C11H15NO4, the mol­ecules are linked into sheets by N—H⋯O and C—H⋯O hydrogen bonds. Within the mol­ecule, the 1,4-dihydro­pyridine ring exhibits a distinctive planar conformation [r.m.s. deviation from the mean plane of 0.009 (3)Å], and the other non-H atoms are almost coplanar [r.m.s. deviation = 0.021 (3) Å] with the 1,4-dihydro­pyridine ring. The conformation of the latter is governed mainly by two intra­molecular C—H⋯O non-classical inter­actions

trans-4,5-Dihydr­oxy-1,3-diphenyl­imidazolidine-2-thione

In the title compound, C15H14N2O2S, the five-membered ring adopts an envelope conformation and the two hydr­oxy groups lie on opposite sides of the ring. The six-membered rings are oriented at a dihedral angle of 22.63 (3)°. In the crystal structure, inter­molecular O—H⋯S and O—H⋯O hydrogen bonds link the mol­ecules into a two-dimensional network

Comprehensive assessment of emergency departments in county-level public hospitals: a multicenter descriptive cross-sectional study in Henan province, China

BackgroundEmergency Departments (EDs) play a crucial role in providing immediate medical care, particularly in densely populated countries like China. While previous research has predominantly focused on well-funded urban hospitals, this study offers a comprehensive evaluation of EDs in county-level public hospitals in Henan province, China, aiming to identify disparities and challenges.MethodsA descriptive cross-sectional survey was conducted in 382 public hospitals across Henan province, China, from July 1, 2023, to August 1, 2023. Data were collected using an electronic questionnaire covering hospital information, human resources, infrastructure, clinical capabilities, and operational capacities. The data collection period for this survey spanned from January 1 to December 31, 2022.ResultsWith a remarkable 94.0% response rate, our study reveals significant disparities in county-level public hospitals compared to their provincial or municipal counterparts in Henan Province, China. County-level hospitals, which constitute 266 of the total 342 surveyed facilities, exhibit notable differences, including fewer doctors (median: 11 vs. 23, p < 0.0001) and nurses (median: 18 vs. 37, p < 0.0001). Additionally, a higher proportion of junior doctors is observed in these hospitals, while senior medical staff are more prevalent in provincial or municipal hospitals (p < 0.001). County-level hospitals also face resource challenges, with fewer beds in the emergency room (median: 4 vs. 7, p = 0.0003) and limited proficiency in advanced clinical procedures such as POCT, fiberoptic bronchoscopy, CRRT, ECMO, ultrasound equipment operation, and intraosseous infusion, with significant differences noted in most of these capabilities (p < 0.05). Operational capabilities show distinctions as well, with county-level hospitals managing a lower patient volume (median: 14,516 vs. 34,703, p < 0.0001) and handling fewer pre-hospital CPR cases (median: 33 vs. 89, p < 0.0001). In-hospital CPR success rates are also lower in county-level hospitals (median ROSC: 25.0% vs. 42.8%, p = 0.0068).ConclusionWhile provincial or municipal hospitals enjoy better resources, county-level hospitals, especially crucial in less urbanized regions, face substantial challenges. Addressing these disparities is imperative, necessitating targeted investments, improved infrastructure, enhanced clinical training, and the adoption of innovations like telemedicine to enhance the quality of emergency care

Assessment of disaster preparedness and related impact factors among emergency nurses in tertiary hospitals: descriptive cross-sectional study from Henan Province of China

BackgroundThe aim of this study was to investigate the current state of disaster preparedness and to determine associated factors among emergency nurses from tertiary hospitals in Henan Province of China.MethodsThis multicenter descriptive cross-sectional study was conducted with emergency nurses from 48 tertiary hospitals in Henan Province of China between September 7, 2022–September 27, 2022. Data were collected through a self-designeds online questionnaire using the mainland China version of the Disaster Preparedness Evaluation Tool (DPET-MC). Descriptive analysis and multiple linear regression analysis were used to evaluate disaster preparedness and to determine factors affecting disaster preparedness, respectively.ResultsA total of 265 emergency nurses in this study displayed a moderate level of disaster preparedness with a mean item score of 4.24 out 6.0 on the DPET-MC questionnaire. Among the five dimensions of the DPET-MC, the mean item score for pre-disaster awareness was highest (5.17 ± 0.77), while that for disaster management (3.68 ± 1.36) was the lowest. Female gender (B = −9.638, p = 0.046) and married status (B = −8.618, p = 0.038) were negatively correlated with the levels of disaster preparedness. Five factors positively correlated with the levels of disaster preparedness included having attended in the theoretical knowledge training of disaster nursing since work (B = 8.937, p = 0.043), having experienced the disaster response (B = 8.280, p = 0.036), having participated in the disaster rescue simulation exercise (B = 8.929, p = 0.039), having participated in the disaster relief training (B = 11.515, p = 0.025), as well as having participated in the training of disaster nursing specialist nurse (B = 16.101, p = 0.002). The explanatory power of these factors was 26.5%.ConclusionEmergency nurses in Henan Province of China need more education in all areas of disaster preparedness, especially disaster management, which needs to be incorporated into nursing education, including formal and ongoing education. Besides, blended learning approach with simulation-based training and disaster nursing specialist nurse training should be considered as novel ways to improve disaster preparedness for emergency nurses in mainland China

Research of detection technology of metal dust concentratio

For problem that weighing method cannot realize real-time and on-line detection for metal dust concentration, basic principle of light scattering method and charge induction method for metal dust concentration detection were analyzed, and signal acquisition and processing circuits for metal dust concentration detection were designed which were respectively based on light scattering method and charge induction method. The experimental results show that errors of light scattering method and charge induction method are small in early detection. Error of light scattering method increases and detection value is higher than standard reference value after long-time continuous detection, while detection accuracy of charge induction method is still high

Research progress of corneal lymphangiogenesis in ocular diseases

Corneal lymphangiogenesis plays a crucial role in ocular diseases. Normally, the cornea lacks blood vessels and lymph vessels, which are essential for maintaining transparency and function of cornea. However, certain diseases or injuries will prompt angiogenesis and lymphangiogenesis in cornea, thus disrupting the structure and function of cornea. Although various drugs targeting corneal angiogenesis have been applied in clinical practice, there is still a gap in medications targeting corneal lymphangiogenesis. Therefore, this review will introduce the factors related to corneal lymphangiogenesis, introduce related ocular diseases, and analyze the current treatment status, which will provide more options and possibilities for the treatment of lymphangiogenesis in ocular diseases and provide guidance for future research and drug development

SBS Content Detection for Modified Asphalt Using Deep Neural Network

This study proposes a prediction model for accurately detecting styrene-butadiene-styrene (SBS) content in modified asphalt using the deep neural network (DNN). Traditional methods used for evaluating the SBS content are inaccurate and complicated because they are prone to produce errors by manual computation. Feature data of SBS content are derived from the spectra, which are obtained by the Fourier-transform infrared spectroscopy test. After designing DNN, preprocessed feature data are utilized as training and testing data and are fed into the DNN via a feature matrix. Furthermore, comparative studies are conducted to verify the accuracy of the proposed model. Results show that the mean square error value decreased by 68% for DNN with noise and dimension reduction. The DNN-based prediction model showed that the correlation coefficient between the target value and the mean predicted value is 0.9978 and 0.9992 for training and testing samples, respectively, indicating its remarkable accuracy and applicability after training. In comparison with the standard curve method and the random forest method, the precision of DNN is greater than 98% for the same test conditions, achieving the best predicting performance

Effective Restrictions on Economic Growth

The fact that the rate of our national industrial growth has been markedly lower than expected since the beginning of this year has aroused universal concern among various circles. Because perceptions of the reasons for this phenomenon are different, the countermeasures that have been proposed differ considerably. On the one hand, in our view, the slowing down of the rate of industrial growth is the result of conscious control exercised over the "high-speed [growth]" through the adoption of various policy measures since last year and is therefore basically normal. Moreover, on the basis of the high-speed growth of last year, the 4.4 percent average growth rate during the first quarter of this year is by no means low and does not warrant too much concern. On the other hand, however, it should also be noted that in the process of slowing down the rate of industrial growth, certain factors in our economic growth and reform that restrict the long-term steady growth of our national economy have been revealed. That is what calls for our close attention and deep reflection.

Comprehensive analysis of vulnerability status and associated affect factors among prehospital emergency patients: a single-center descriptive cross-sectional study

BackgroundPrehospital emergency care is a critical but often understudied aspect of healthcare. Patient vulnerability in this setting can significantly impact outcomes. The aim of this study was to investigate the vulnerability status and to determine associated affect factors among prehospital emergency patients in China.MethodsIn this cross-sectional study conducted in China, from April 2023 to July 2023, we assessed the vulnerability of prehospital emergency patients using the Safety in Prehospital Emergency Care Index (SPECI) scale. We conducted a detailed questionnaire-based survey to gather demographic and disease-related information. We employed the SPECI scale, consisting of two subscales, to evaluate patient vulnerability. Statistical analyses, including t-tests, ANOVA, and multiple linear regression, were used to identify factors associated with vulnerability.ResultsThe study included a total of 973 prehospital emergency patients, with a response rate of 81.9%. These patients exhibited a low-to-moderate level of vulnerability, with an average SPECI score of 14.46 out of 40. Vulnerability was significantly associated with age (particularly those aged 60 and above), disease severity (severe conditions increased vulnerability), disease type (circulatory diseases correlated with higher vulnerability), alterations in consciousness, and chronic diseases. Unexpectedly, digestive system diseases were negatively correlated with vulnerability.ConclusionAddressing patient vulnerability in prehospital care is essential. Tailored interventions, EMS provider training, and interdisciplinary collaboration can mitigate vulnerability, especially in older patients and those with severe conditions