Locate QCD Critical End Point in a Continuum Model Study

With a modified chemical potential dependent effective model for the gluon propagator, we try to locate the critical end point (CEP) of strongly interacting matter in the framework of Dyson-Schwinger equations (DSE). Beyond the chiral limit, we find that Nambu solution and Wigner solution could coexist in some area. Using the CornwallJackiw-Tomboulis (CJT) effective action, we show that these two phases are connected by a first order phase transition. We then locate CEP as the end point of the first order phase transition line. Meanwhile, based on CJT effective action, we give a direct calculation for the chiral susceptibility and thereby study the crossover.Comment: 9 pages, 7 figures; Version published in JHE

A Robust Quantum Random Access Memory

A "bucket brigade" architecture for a quantum random memory of $N=2^n$ memory cells needs $n(n+5)/2$ times of quantum manipulation on control circuit nodes per memory call. Here we propose a scheme, in which only average $n/2$ times manipulation is required to accomplish a memory call. This scheme may significantly decrease the time spent on a memory call and the average overall error rate per memory call. A physical implementation scheme for storing an arbitrary state in a selected memory cell followed by reading it out is discussed.Comment: 5 pages, 3 figure

N′-(4-Cyano­benzyl­idene)thio­phene-2-carbohydrazide

The title compound, C13H9N3OS, was prepared by the reaction of thio­phene-2-carbohydrazide and 4-formyl­benzonitrile. The dihedral angle between the benzene and thio­phene rings is 11.9 (1)°. In the crystal structure, mol­ecules are linked into centrosymmetric dimers by pairs of N—H⋯O hydrogen bonds

NMDA receptor internalization down-regulates NMDA receptor-mediated synaptic responses through the inhibition of remaining (non-internalized) surface NMDA receptors

Cell-surface protein endocytosis is critically involved in the regulation of organismal homeostasis, immune responses, development and neurotransmission [1,2,3,4]. Mechanisms underlying the endocytosis of cell surface proteins have been extensively investigated. However, until very recently no study has reported how non-internalized cell surface proteins may behave following endocytosis of same type of proteins. Here, we highlight findings that regulated NMDA receptor (NMDAR) internalization not only reduces the amount of NMDARs expressed on neuronal surface but also through activating PKD1 pathway phosphorylates and down-regulates remaining (non-internalized) surface NMDARs. This down-regulation of remaining surface NMDARs plays a critical role in the modulation of NMDAR-mediated synaptic responses by NMDAR internalization

Access to aff ordable medicines after health reform: evidence from two cross-sectional surveys in Shaanxi Province,western China

Background Limited access to essential medicines is a global problem. Improving availability and aff ordability of essential medicines is a key objective of the National Essential Medicine Policy (NEMP) in China. In its initial implementation in 2009, the NEMP targeted primary hospitals with policies designed to increase availability of essential medicines and reduce patients’ economic burden from purchasing medicines. We assessed medicine availability and price during the early years of the health reform in Shaanxi Province in underdeveloped western China. Methods We undertook two public (hospitals) and private (pharmacy) sector surveys of prices and availability of medicines, in September, 2010 and April, 2012, by a standard methodology developed by WHO and Health Action International. We measured medicine availability in outlets at the time of the surveys and infl ation-adjusted median unit prices (MUPs), taking 2010 as the base year. We used general estimating equations to calculate the signifi cance of diff erences in availability from 2010 to 2012 and the Wilcoxon signed rank test to calculate the signifi cance of diff erences in adjusted median prices. Findings We collected data from 50 public sector hospitals and 36 private sector retail pharmacies in 2010 and 72 public hospitals and 72 retail pharmacies in 2012. Mean availability of surveyed medicines was low in both the public and private sectors; availability of many essential medicines decreased from 2010 to 2012, particularly in primary hospitals (from 27·4% to 22·3% for lowest priced generics; p<0·0001). The MUPs of originator brands and their generic equivalents decreased signifi cantly from 2010 to 2012 in primary hospitals in comparison with secondary and tertiary hospitals. In the public sector, the median adjusted patient price was signifi cantly lower in 2012 than in 2010 for 16 originator brands (diff erence –11·7%; p=0·0019) and 29 lowest-priced generics (–5·2%; p=0·0015); the median government procurement price for originator brands also decreased signifi cantly (–10·9%; p=0·0004), whereas the decrease in median procurement price for lowest-priced generics was not signifi cant (–4·9%; p=0·17). In the private sector, the median percentage decrease in price between 2010 and 2012 for 38 lowest-priced generics was 4·7% (IQR 6·3–13·2), compared with 7·9% (4·9–13·9) for 16 originator brands. Interpretation Although infl ation-adjusted medicine prices were numerically lower, there were concerning decreases in availability of lowest-priced generic medicines in both the public and private sectors in 2012 from already low availability in 2010. A long-term, stable, and consistent information system is needed to monitor eff ects of further implementation of the Chinese Essential Medicine Policy