Studies into iridium-catalysed asymmetric allylic alkylation towards the total synthesis of a dolabellane

In recent years, iridium-catalysed asymmetric allylic substitution has received considerable attention because it is a valuable tool to selectively synthesise chiral compounds with high ee from simple starting materials. This thesis presents an efficient catalytic system for the decarboxylative iridium-catalysed asymmetric allylic alkylation (AAA) in which a wide range of allylic &beta;-ketoester substrates was converted into chiral ketones in good yields with high regio- and enantioselectivities. A possible mechanism for decarboxylative iridium-catalysed AAA is also proposed in this thesis.</p

Studies into iridium-catalysed asymmetric allylic alkylation towards the total synthesis of a dolabellane

In recent years, iridium-catalysed asymmetric allylic substitution has received considerable attention because it is a valuable tool to selectively synthesise chiral compounds with high ee from simple starting materials. This thesis presents an efficient catalytic system for the decarboxylative iridium-catalysed asymmetric allylic alkylation (AAA) in which a wide range of allylic β-ketoester substrates was converted into chiral ketones in good yields with high regio- and enantioselectivities. A possible mechanism for decarboxylative iridium-catalysed AAA is also proposed in this thesis.</p

An improved synthesis of n-(4-[18 f]fluorobenzoyl)-interleukin-2 for the preclinical pet imaging of tumour-infiltrating t-cells in ct26 and mc38 colon cancer models

10.3390/molecules26061728Molecules266172