COVID-19流行前後の中国幼児の身体状況と生活習慣の実態と課題

早稲田大学博士(人間科学)早大学位記番号:新9416doctoral thesi

Prenatal diagnosis and clinical management of cardiac rhabdomyoma: a single-center study

ObjectiveThe study aims to assess the ultrasonic features of fetal cardiac rhabdomyoma (CR), track the perinatal outcome and postnatal disease progression, investigate the clinical utility of ultrasound, MRI and tuberous sclerosis complex (TSC) gene analysis in CR evaluation, and offer evidence for determing of fetal CR prognosis.MethodsWe conducted a retrospective analysis of prenatal ultrasound-diagnosed fetal CR cases in our hospital from June 2011 to June 2022, tracked the perinatal outcomes, regularly followed live infants to analyze cardiac lesion changes and disease progression, and compared the sensitivities of ultrasound, MRI and their combination in the detecting of intracranial sclerosing nodules.ResultsOur study included 54 fetuses with CR: 32 pregnancies were terminated, 22 were delivered, 35 were diagnosed with TSC, 13 had simple CR without TSC, and in 6 cases, remained unclear whether TSC accompanied the CR due to insufficient evidence. 45 fetuses (83.3%) had multiple lesions, while 9 fetuses (16.7%) presented with a single lesion. Twelve cases had intracardiac complications, all associated with multiple lesions, and these cases exhibited larger maximum tumor diameters than the non-complicated group. Multiple intracardiac lesions were more prevalent in the TSC group than in the simple CR group. However, there was no significant difference in maximum tumor diameter between the two groups. Among 30 fetuses who underwent fetal brain MRI, 23 were eventually diagnosed with TSC, with 11 fetuses showing intracranial sclerosis nodules by ultrasound and 15 by MRI, and the diagnostic consistency was moderate (k = 0.60). Twenty-two fetuses were born and followed up for 6–36 months. CR lesions diminished or disappeared in 18 infants (81.8%), while they remained unchanged in 4 infants (18.2%). Ten out of 12 (83.3%) surviving children diagnosed with TSC developed epilepsy, and 7 (58.3%) had neurodevelopmental dysfunction.ConclusionsThe majority of CR cases involve multiple lesions, which are a primary risk factor for TSC. Through prenatal ultrasound examination is crucial for assessing fetal CR prognosis. Although ultrasound combined with MRI can detect intracranial sclerosis nodules in TSC fetuses, its sensitivity is limited. TSC gene sequencing is an essential diagnostic method. Simple CR cases without TSC generally have a favorable prognosis

博士論文要旨 : E. 健康福祉科学研究領域

departmental bulletin pape

Engineering zinc oxide hybrid selenium nanoparticles for synergetic anti-tuberculosis treatment by combining Mycobacterium tuberculosis killings and host cell immunological inhibition

IntroductionAs a deadly disease induced by Mycobacterium tuberculosis (Mtb), tuberculosis remains one of the top killers among infectious diseases. The low intracellular Mtb killing efficiency of current antibiotics introduced the long duration anti-TB therapy in clinic with strong side effects and increased drug-resistant mutants. Therefore, the exploration of novel anti-TB agents with potent anti-TB efficiency becomes one of the most urgent issues for TB therapies. MethodsHere, we firstly introduced a novel method for the preparation of zinc oxide-selenium nanoparticles (ZnO-Se NPs) by the hybridization of zinc oxide and selenium to combine the anti-TB activities of zinc oxide nanoparticles and selenium nanoparticles. We characterized the ZnO-Se NPs by dynamic laser light scattering and transmission electron microscopy, and then tested the inhibition effects of ZnO-Se NPs on extracellular Mtb by colony-forming units (CFU) counting, bacterial ATP analysis, bacterial membrane potential analysis and scanning electron microscopy imaging. We also analyzed the effects of ZnO-Se NPs on the ROS production, mitochondrial membrane potential, apoptosis, autophagy, polarization and PI3K/Akt/mTOR signaling pathway of Mtb infected THP-1 macrophages. At last, we also tested the effects of ZnO-Se NPs on intracellular Mtb in THP-1 cells by colony-forming units (CFU) counting. ResultsThe obtained spherical core-shell ZnO-Se NPs with average diameters of 90 nm showed strong killing effects against extracellular Mtb, including BCG and the virulent H37Rv, by disrupting the ATP production, increasing the intracellular ROS level and destroying the membrane structures. More importantly, ZnO-Se NPs could also inhibit intracellular Mtb growth by promoting M1 polarization to increase the production of antiseptic nitric oxide and also promote apoptosis and autophagy of Mtb infected macrophages by increasing the intracellular ROS, disrupting mitochondria membrane potential and inhibiting PI3K/Akt/mTOR signaling pathway. DiscussionThese ZnO-Se NPs with synergetic anti-TB efficiency by combining the Mtb killing effects and host cell immunological inhibition effects were expected to serve as novel anti-TB agents for the development of more effective anti-TB strategy

Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting

Glioblastoma is the most malignant cancer in the brain and currently incurable. It is urgent to identify effective targets for this lethal disease. Inhibition of such targets should suppress the growth of cancer cells and, ideally also precancerous cells for early prevention, but minimally affect their normal counterparts. Using genetic mouse models with neural stem cells (NSCs) or oligodendrocyte precursor cells (OPCs) as the cells‐of‐origin/mutation, it is shown that the susceptibility of cells within the development hierarchy of glioma to the knockout of insulin‐like growth factor I receptor (IGF1R) is determined not only by their oncogenic states, but also by their cell identities/states. Knockout of IGF1R selectively disrupts the growth of mutant and transformed, but not normal OPCs, or NSCs. The desirable outcome of IGF1R knockout on cell growth requires the mutant cells to commit to the OPC identity regardless of its development hierarchical status. At the molecular level, oncogenic mutations reprogram the cellular network of OPCs and force them to depend more on IGF1R for their growth. A new‐generation brain‐penetrable, orally available IGF1R inhibitor harnessing tumor OPCs in the brain is also developed. The findings reveal the cellular window of IGF1R targeting and establish IGF1R as an effective target for the prevention and treatment of glioblastoma

Optimization of Inter-industry Carbon Emission Transfer Structure Based on Decoupling Effects: an empirical analysis from Chinese industry

This paper utilizes 27 Chinese industry sectors as study objects, and measures the decoupling effects of the industrial carbon emission transfer; furthermore, this paper proposes several optimizing strategies for an inter-industry carbon emission transfer structure toward the realization of dual goals, i.e., industrial economic development and industrial carbon emission reduction. The research result shows that: Different industries show different decoupling effects of carbon emission transfer, and the distribution of the six states of decoupling effects could all be observed. With respect to dynamic variations, the decoupling effects of industrial carbon emission transfer were optimal during the late stage, and the decoupling effects during 2010-2012 were the most optimal. With respect to the optimizing strategies for the inter-industry carbon emission transfer, efforts should be focused on increasing the carbon emission exports, while reducing the carbon emission imports of 11 industries (CMWI and others). Future efforts should be directed at increasing carbon emission imports and reducing carbon emission exports in the three industries of CLII, PPSM, and MPI, while increasing both carbon emission exports and imports in 10 industries (FMTP and others), and reducing both carbon emission imports and exports in the three industries of MMII, OMW, and WRT

Optimization of Inter-industry Carbon Emission Transfer Structure Based on Decoupling Effects: an empirical analysis from Chinese industry

This paper utilizes 27 Chinese industry sectors as study objects, and measures the decoupling effects of the industrial carbon emission transfer; furthermore, this paper proposes several optimizing strategies for an inter-industry carbon emission transfer structure toward the realization of dual goals, i.e., industrial economic development and industrial carbon emission reduction. The research result shows that: Different industries show different decoupling effects of carbon emission transfer, and the distribution of the six states of decoupling effects could all be observed. With respect to dynamic variations, the decoupling effects of industrial carbon emission transfer were optimal during the late stage, and the decoupling effects during 2010-2012 were the most optimal. With respect to the optimizing strategies for the inter-industry carbon emission transfer, efforts should be focused on increasing the carbon emission exports, while reducing the carbon emission imports of 11 industries (CMWI and others). Future efforts should be directed at increasing carbon emission imports and reducing carbon emission exports in the three industries of CLII, PPSM, and MPI, while increasing both carbon emission exports and imports in 10 industries (FMTP and others), and reducing both carbon emission imports and exports in the three industries of MMII, OMW, and WRT

修士論文要旨 : 中国の地域別にみた幼児の生活習慣の実態と課題

departmental bulletin pape

A Control Parameters Self-Adjusting Method for photovoltaic inverter considering the variation of inductance

The variation of inductance is the reason for the instability of photovoltaic (PV) inverter system. To this end, a control parameters self-adjusting method considering the variation of inductance is proposed to enhance the anti-interference ability. The basic control method is to use grid-connected current control and capacitor-current-feedback method to suppress resonance. Based on the Routh Criterion (RC), a simple Routh Array enumeration rule is proposed. Discrete Routh Criterion (RC) is selected as the stability analysis method to obtain the stability range of the control parameters. The control parameters self-adjusting method can enhance the anti-interference ability of system under variations of inductance, which is proved by comparative experiments