Peripheral Leukocytapheresis Attenuates Acute Lung Injury Induced by Lipopolysaccharide In Vivo

The mortality of acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains high and efforts for prevention and treatments have shown little improvement over the past decades. The present study investigated the efficacy and mechanism of leukocytapheresis (LCAP) to partially eliminate peripheral neutrophils and attenuate lipopolysaccharide (LPS)-induced lung injury in dogs. A total of 24 healthy male mongrel dogs were enrolled and randomly divided into LPS, LCAP and LCAP-sham groups. All animals were injected with LPS to induce endotoxemia. The serum levels of leucocytes, neutrophil elastase, arterial blood gas, nuclear factor-kappa B (NF-κB) subunit p65 in lung tissues were measured. The histopathology and parenchyma apoptosis of lung tissues were examined. We found that 7, 3, and 7 animals in the LPS, LCAP, and sham-LCAP groups, respectively, developed ALI 36 h after LPS infusion. The levels of NF-κB p65 in lung tissue, neutrophils and elastase in blood, decreased significantly following LCAP. LCAP also alleviated apoptosis, and NF-κB p65 in lung tissues. Collectively, our results show that partial removal of leucocytes from peripheral blood decreases elastase level in serum. This, in turn, attenuates lung injuries and may potentially decrease the incidence of ALI

Strong Gravitational Lensing of Gravitational Waves with TianQin

When gravitational waves pass by a massive object on its way to the Earth, strong gravitational lensing effect will happen. Thus the GW signal will be amplified, deflected, and delayed in time. Through analysing the lensed GW waveform, physical properties of the lens can be inferred. On the other hand, neglecting lensing effects in the analysis of GW data may induce systematic errors in the estimating of source parameters. As a space-borne GW detector, TianQin will be launched in the 2030s. It is expected to detect dozens of MBHBs merger as far as z = 15, and thus will have high probability to detect at least one lensed event during the mission lifetime. In this article, we discuss the capability of TianQin to detect lensed MBHBs signals. Three lens models are considered in this work: the point mass model, the SIS model, and the NFW model. The sensitive frequency band for space-borne GW detectors is around milli-hertz, and the corresponding GW wavelength could be comparable to the lens gravitational length scale, which requires us to account for wave diffraction effects. In calculating lensed waveforms, we adopt the approximation of geometric optics at high frequencies to accelerate computation, while precisely evaluate the diffraction integral at low frequencies. Through a Fisher analysis, we analyse the accuracy to estimate the lens parameters. We find that the accuracy can reach to the level of 10^-3 for the mass of point mass and SIS lens, and to the level of 10^-5 for the density of NFW lens. We also assess the impact on the accurate of estimating the source parameters, and find that the improvement of the accuracy is dominated by the increasing of SNR.Comment: 12 pages, 8 figure

An Opacity-Free Method of Testing the Cosmic Distance Duality Relation Using Strongly Lensed Gravitational Wave Signals

The cosmic distance duality relation (CDDR), expressed as DL(z) = (1 + z)2DA(z), plays an important role in modern cosmology. In this paper, we propose a new method of testing CDDR using strongly lensed gravitational wave (SLGW) signals. Under the geometric optics approximation, we calculate the gravitational lens effects of two lens models, the point mass and singular isothermal sphere. We use functions of {\eta}1(z) = 1 + {\eta}0z and {\eta}2(z) = 1 + {\eta}0z=(1 + z) to parameterize the deviation of CDDR. By reparameterizing the SLGW waveform with CDDR and the distance-redshift relation, we include the deviation parameters {\eta}0 of CDDR as waveform parameters. We evaluate the ability of this method by calculating the parameter estimation of simulated SLGW signals from massive binary black holes. We apply the Fisher information matrix and Markov Chain Monte Carlo methods to calculate parameter estimation. We find that with only one SLGW signal, the measurement precision of {\eta}0 can reach a considerable level of 0.5-1.3% for {\eta}1(z) and 1.1-2.6% for {\eta}2(z), depending on the lens model and parameters.Comment: 15 pages, 7 figure

Measuring the Hubble Constant Using Strongly Lensed Gravitational Wave Signals

The measurement of the Hubble constant $H_0$ plays an important role in the study of cosmology. In this letter, we propose a new method to constrain the Hubble constant using the strongly lensed gravitational wave (GW) signals. By reparameterizing the waveform, we find that the lensed waveform is sensitive to the $H_0$. Assuming the scenario that no electromagnetic counterpart of the GW source can be identified, our method can still give meaningful constraints on the $H_0$ with the information of the lens redshift. We then apply Fisher information matrix and Markov Chain Monte Carlo to evaluate the potential of this method. For the space-based GW detector, TianQin, the $H_0$ can be constrained within a relative error of $\sim$ 0.3-2\%, using a single strongly lensed GW event. Precision varies according to different levels of electromagnetic information.Comment: 8 pages, 4 figure

Isospin Effect on the Process of Multifragmentation and Dissipation at Intermediate Energy Heavy Ion Collisions

In the simulation of intermediate energy heavy ion collisions by using the isospin dependent quantum molecular dynamics, the isospin effect on the process of multifragmentation and dissipation has been studied. It is found that the multiplicity of intermediate mass fragments $N_{imf}$ for the neutron-poor colliding system is always larger than that for the neutron-rich system, while the quadrupole of single particle momentum distribution $Q_{zz}$ for the neutron-poor colliding system is smaller than that of the neutron-rich system for all projectile-target combinations studied at the beam energies from about 50MeV/nucleon to 150MeV/nucleon. Since $Q_{zz}$ depends strongly on isospin dependence of in-medium nucleon-nucleon cross section and weakly on symmetry potential at the above beam energies, it may serve as a good probe to extract the information on the in-medium nucleon-nucleon cross section. The correlation between the multiplicity $N_{imf}$ of intermediate mass fragments and the total numer of charged particles $N_c$ has the behavior similar to $Q_{zz}$, which can be used as a complementary probe to the in-medium nucleon-nucleon cross section.Comment: 18 pages, 9 figure