Dynamics of glass phases in the two-dimensional gauge glass model

Large-scale simulations have been performed on the current-driven two-dimensional XY gauge glass model with resistively-shunted-junction dynamics. It is observed that the linear resistivity at low temperatures tends to zero, providing strong evidence of glass transition at finite temperature. Dynamic scaling analysis demonstrates that perfect collapses of current-voltage data can be achieved with the glass transition temperature $T_{g}=0.22$, the correlation length critical exponent $\nu =1.8$, and the dynamic critical exponent $z=2.0$. A genuine continuous depinning transition is found at zero temperature. For creeping at low temperatures, critical exponents are evaluated and a non-Arrhenius creep motion is observed in the glass phase.Comment: 10 pages, 6 figure

Phase transition in site-diluted Josephson junction arrays: A numerical study

We numerically investigate the intriguing effects produced by random percolative disorder in two-dimensional Josephson-junction arrays. By dynamic scaling analysis, we evaluate critical temperatures and critical exponents with high accuracy. It is observed that, with the introduction of site-diluted disorder, the Kosterlitz-Thouless phase transition is eliminated and evolves into a continuous transition with power-law divergent correlation length. Moreover, genuine depinning transition and creep motion are studied, evidence for distinct creep motion types is provided. Our results not only are in good agreement with the recent experimental findings, but also shed some light on the relevant phase transitions.Comment: 7 pages, 8 figures, Phys. Rev. B (in press

The Effect of Flow and Motivation on Users’ Learning Outcomes in Second Life

This study aims to investigate the effect of the users’ immersion experience, motivation, and learning outcomes in Second Life. The data collected for this study occurred over a 2 month period. Participants were 113 students taking classes in Second Life at a university. Their ages ranged from 18-22 years, with 47 participants as male and 66 as female. From the analysis of the collected data, the immersion experience and motivation have effects on the learning outcomes in Second Life. The results revealed more one was immersed in Second Life, the motivation was improved, and thus, the learning outcomes were reinforced. These findings are also discussed in virtual learning and teaching design

Genomic Features and Clinical Characteristics of Adolescents and Young Adults With Cholangiocarcinoma

Background: Adolescents and young adults (AYAs) diagnosed with cancer between ages 15 and 45 years may exhibit unique biologic and genomic characteristics as well as clinical features, resulting in differences in clinical characters and drug resistance. However, compared to other solid cancers, relatively few studies have been conducted in this age group in cholangiocarcinoma (CCA). This study is performed to investigate the clinical and molecular features of AYAs with CCA. Methods: Three cohorts, including the external dataset (TCGA and MSKCC) and the perihilar CCA databank of Chinese tertiary hospitals, were contained in this study. Pathway and process enrichment analysis had been carried out with the following ontology sources: KEGG Pathway, GO Biological Processes, Reactome Gene Sets, Canonical Pathways, and CORUM. Metascape and GEPIA datasets were used for bioinformatic analysis. P < 0.05 was considered statistically significant. All statistical analyses were performed with GraphPad Prism (version 7.0; GraphPad Software, La Jolla, California) and R studio (version 3.6.1; R studio, Boston, Massachusetts). Results: Compared to older adults, AYAs with CCA presented with worse overall survival, although the difference was not significant. Specific to patients with stage IV CCAs who underwent chemotherapy, AYAs were associated with significantly poorer overall survival (OS) (p = 0.03, hazards ratio (HR) 3.01, 95% confidence interval (CI) 1.14-4.91). From the anatomical perspective, more extrahepatic CCA was detected in the AYA group. Microsatellite instability (MSI) occurred in 3% of older patients in the present study. Nevertheless, none of the AYAs had MSI status. In this study, AYAs gained an enhanced frequency of additional sex combs like 1 (ASXL1) (p = 0.02) and KMT2C (p = 0.02) mutation than their older counterparts. Besides ASXL1 and KMT2C, the genes enriched in AYAs with CCA were analyzed by pathway and process enrichment analysis. And those genes were found to be associated with poorer differentiation, deubiquitination, and WNT signal pathway. Moreover, AYAs were relevant to poor differentiation and advanced tumor stage. Conclusion: This study offered a preliminary landscape of the clinical and molecular features of early-onset biliary cancers. Further studies including more samples are essential to investigate whether ASXL1 and KMT2C could be considered as potentially targetable genomic signatures for young patients