Synthetic Topological Degeneracy by Anyon Condensation

Topological degeneracy is the degeneracy of the ground states in a many-body system in the large-system-size limit. Topological degeneracy cannot be lifted by any local perturbation of the Hamiltonian. The topological degeneracies on closed manifolds have been used to discover/define topological order in many-body systems, which contain excitations with fractional statistics. In this paper, we study a new type of topological degeneracy induced by condensing anyons along a line in 2D topological ordered states. Such topological degeneracy can be viewed as carried by each end of the line-defect, which is a generalization of Majorana zero-modes. The topological degeneracy can be used as a quantum memory. The ends of line-defects carry projective non-Abelian statistics, and braiding them allow us to perform fault tolerant quantum computations.Comment: 4 pages + references + 3 pages of supplementary material, 2 figures. reference update

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease

Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene inhibits macrophages infiltrated and inflammatory mediators in vein graft disease. Autologous rabbit jugular vein grafts were incubated ex vivo in a solution of mosaic adeno-associated virus vectors containing CGRP gene (AAV2/1.CGRP) 、escherichia coli lac Z gene (AAV2/1.LacZ) or saline and then interposed in the carotid artery. Intima/media ratio were evaluated at postoperative 4 weeks, Macrophages were marked with CD68 antibody by immunocytochemistry. Inflammatory mediators were mensurated with real-time PCR. Neointimal thickening was significantly suppressed in AAV2/1.CGRP group. Macrophages infiltrated and inflammatory mediators monocyte chemoattractant protein-1 (MCP-1)、tumor necrosis factorα(TNF-α)、inducible nitricoxide synthase (iNOS)、matrix metalloproteinase-9 (MMP-9) was significantly suppressed in AAV2/1.CGRP group.Gene transfected AAV2/1.CGRP suppressed neointimal hyperplasia in vein graft disease by suppressed macrophages infiltrated and inflammatory mediators