5,130 research outputs found
Thermodynamics of SU(2) bosons in one dimension
On the basis of Bethe ansatz solution of two-component bosons with SU(2)
symmetry and -function interaction in one dimension, we study the
thermodynamics of the system at finite temperature by using the strategy of
thermodynamic Bethe ansatz (TBA). It is shown that the ground state is an
isospin "ferromagnetic" state by the method of TBA, and at high temperature the
magnetic property is dominated by Curie's law. We obtain the exact result of
specific heat and entropy in strong coupling limit which scales like at low
temperature. While in weak coupling limit, it is found there is still no
Bose-Einstein Condensation (BEC) in such 1D system.Comment: 7 page
Pathogenetic role of tissue factor in graft-versus-host disease
Graft-versus-host disease (GVHD) is a serious complication after allogeneic stem cell transplantation, the mechanism of it is still not elucidated. Recent findings suggest that host endothelial cells are a target of alloreactive donor cytotoxic T lymphocytes in GVHD and tissue factor (TF) plays an important role not only in coagulation-inflammation cycle, but also in transplant immunology. We postulate TF expression in vascular endothelial cells(VEC) may play an pivotal role in the pathogenesis of GVHD. TF gene andprotein expression in target organs of GVHD in aGVHD mice was significantly elevated compared to that of controls as determined by real-time PCR and Western blotting. Allogeneic CD4^+^T cell and CD8^+^T cells enhanced TF, VCAM-1, TNF-[alpha], IFN-[gamma] and IL-6 expression in TNF-[alpha] prestimulated HUVECs compared to controls as determined by flowcytometry and real-time PCR. JNK and p38MAPK mediated allogeneic T cells-induced TF expression in HUVECs. These effects were largely prevented by monoclonal antibody against TF, SB203580 and SP600125. In concert, these data provide strong evidence that upregulated TF expression is related to tissue damage caused by GVHD, TF isthe key factor in GVHD mediated by endothelial cells and allogeneic T cells-induced TF and consecutive proinflammatory cytokines expression in VEC contribute to the pathogenesis of GVHD
On Resource Pooling and Separation for LRU Caching
Caching systems using the Least Recently Used (LRU) principle have now become
ubiquitous. A fundamental question for these systems is whether the cache space
should be pooled together or divided to serve multiple flows of data item
requests in order to minimize the miss probabilities. In this paper, we show
that there is no straight yes or no answer to this question, depending on
complex combinations of critical factors, including, e.g., request rates,
overlapped data items across different request flows, data item popularities
and their sizes. Specifically, we characterize the asymptotic miss
probabilities for multiple competing request flows under resource pooling and
separation for LRU caching when the cache size is large.
Analytically, we show that it is asymptotically optimal to jointly serve
multiple flows if their data item sizes and popularity distributions are
similar and their arrival rates do not differ significantly; the
self-organizing property of LRU caching automatically optimizes the resource
allocation among them asymptotically. Otherwise, separating these flows could
be better, e.g., when data sizes vary significantly. We also quantify critical
points beyond which resource pooling is better than separation for each of the
flows when the overlapped data items exceed certain levels. Technically, we
generalize existing results on the asymptotic miss probability of LRU caching
for a broad class of heavy-tailed distributions and extend them to multiple
competing flows with varying data item sizes, which also validates the Che
approximation under certain conditions. These results provide new insights on
improving the performance of caching systems
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