Cross-Domain Image Retrieval with Attention Modeling

With the proliferation of e-commerce websites and the ubiquitousness of smart phones, cross-domain image retrieval using images taken by smart phones as queries to search products on e-commerce websites is emerging as a popular application. One challenge of this task is to locate the attention of both the query and database images. In particular, database images, e.g. of fashion products, on e-commerce websites are typically displayed with other accessories, and the images taken by users contain noisy background and large variations in orientation and lighting. Consequently, their attention is difficult to locate. In this paper, we exploit the rich tag information available on the e-commerce websites to locate the attention of database images. For query images, we use each candidate image in the database as the context to locate the query attention. Novel deep convolutional neural network architectures, namely TagYNet and CtxYNet, are proposed to learn the attention weights and then extract effective representations of the images. Experimental results on public datasets confirm that our approaches have significant improvement over the existing methods in terms of the retrieval accuracy and efficiency.Comment: 8 pages with an extra reference pag

Nature of proton transport in a water-filled carbon nanotube and in liquid water

Proton transport (PT) in bulk liquid water and within a thin water-filled carbon nanotube has been examined with ab initio pathintegral molecular dynamics (PIMD). Barrierless proton transfer is observed in each case when quantum nuclear effects (QNEs) are accounted for. The key difference between the two systems is that in the nanotube facile PT is facilitated by a favorable prealignment of water molecules, whereas in bulk liquid water solvent reorganization is required prior to PT. Configurations where the quantum excess proton is delocalized over several adjacent water molecules along with continuous interconversion between different hydration states reveals that, as in liquid water, the hydrated proton under confinement is best described as a fluxional defect, rather than any individual idealized hydration state such as Zundel, Eigen, or the so-called linear H7O3+ complex along the water chain. These findings highlight the importance of QNEs in intermediate strength hydrogen bonds (HBs) and explain why H+ diffusion through nanochannels is impeded much less than other cations.Comment: 6 pages, 4 figure

A New Version of Rectification for the Leaning Structures and Foundations

A new version of the rectification technique tor the leaning structure and foundation developed by Wuhan Foundation Engineering Center was used to restore the tilted columns to their original position. The main idea of this new method is to apply adjusting loads on the foundation through anchors or short piles. According to the tilting conditions the anchors or piles can be installed at one side or at both sides of the tilting foundations. The loads can be applied in successive increments until the final desired positions were reached. By using this technique a tilted warehouse was completely restored to its working condition and given below as a typical example of case history

The clinical potential of microRNAs

MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. In fact, recent studies have shown the utility of microRNAs as cancer-related biomarkers. This is due to the finding that microRNAs display altered expression profiles in cancers versus normal tissue. In addition, microRNAs have been associated with cancer progression. In this review, the mechanisms to alter microRNA expression and their relation to cancer will be addressed. Moreover, the potential application of microRNAs in clinical settings will also be highlighted. Finally, the challenges regarding the translation of research involving microRNAs to the clinical realm will be discussed

Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma

<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) is a malignant cancer with an observable heterogeneity and microRNAs are functionally associated with the tumorigenesis of HCC. We recently identified that EpCAM (CD326)-positive cells isolated from alpha-fetoprotein (AFP)-positive HCC samples are hepatic cancer stem cells (HepCSCs). EpCAM⁺AFP⁺HepCSCs have an activated Wnt/β-catenin signaling with a parallel increased expression of all four microRNA-181 family members. We hypothesized that Wnt/β-catenin signaling transcriptionally activates microRNA-181s in HCC.</p> <p>Results</p> <p>Using both western blot and quantitative reverse transcriptase-PCR analyses, we found that the expression of all four microRNA-181 family members was positively correlated with β-catenin expression in HCC cell lines. MicroRNA-181 expression could be directly induced upon an activation of Wnt/β-catenin signaling, which includes Wnt10B overexpression, inhibition of GSK3β signaling by LiCl, or forced expression of β-catenin/Tcf4. Moreover, microRNA-181 expression was inhibited upon an inactivation of Wnt/β-catenin signaling by an induction of adenomatosis polyposis coli (APC) expression or silencing β-catenin via RNA interference. In addition, seven putative β-catenin/Tcf4 binding sites were identified in the promoter region of the microRNA-181a-2 and microRNA-181b-2 transcripts. Consistently, we found that Tcf4 interacted with these regions <it>in vivo </it>using chromatin immunoprecipitation assay.</p> <p>Conclusions</p> <p>Taken together, our results demonstrate that microRNA-181s are transcriptionally activated by the Wnt/beta-catenin signaling pathway in HCC.</p