480 research outputs found
Molecular Beam Epitaxy Growth of Superconducting LiFeAs Film on SrTiO3(001) Substrate
The stoichiometric "111" iron-based superconductor, LiFeAs, has attacted
great research interest in recent years. For the first time, we have
successfully grown LiFeAs thin film by molecular beam epitaxy (MBE) on
SrTiO3(001) substrate, and studied the interfacial growth behavior by
reflection high energy electron diffraction (RHEED) and low-temperature
scanning tunneling microscope (LT-STM). The effects of substrate temperature
and Li/Fe flux ratio were investigated. Uniform LiFeAs film as thin as 3
quintuple-layer (QL) is formed. Superconducting gap appears in LiFeAs films
thicker than 4 QL at 4.7 K. When the film is thicker than 13 QL, the
superconducting gap determined by the distance between coherence peaks is about
7 meV, close to the value of bulk material. The ex situ transport measurement
of thick LiFeAs film shows a sharp superconducting transition around 16 K. The
upper critical field, Hc2(0)=13.0 T, is estimated from the temperature
dependent magnetoresistance. The precise thickness and quality control of
LiFeAs film paves the road of growing similar ultrathin iron arsenide films.Comment: 7 pages, 6 figure
Visualizing the elongated vortices in -Ga nanostrips
We study the magnetic response of superconducting -Ga via low
temperature scanning tunneling microscopy and spectroscopy. The magnetic vortex
cores rely substantially on the Ga geometry, and exhibit an unexpectedly-large
axial elongation with aspect ratio up to 40 in rectangular Ga nano-strips
(width 100 nm). This is in stark contrast with the isotropic circular
vortex core in a larger round-shaped Ga island. We suggest that the unusual
elongated vortices in Ga nanostrips originate from geometric confinement effect
probably via the strong repulsive interaction between the vortices and Meissner
screening currents at the sample edge. Our finding provides novel conceptual
insights into the geometrical confinement effect on magnetic vortices and forms
the basis for the technological applications of superconductors.Comment: published in Phys. Rev. B as a Rapid Communicatio
Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells
<p>Abstract</p> <p>Background</p> <p>The exact mechanism of the effects of hypoxia on the proliferation and apoptosis in carcinoma cells is still conflicting. This study investigated the variation of hypoxia-inducible factor-1α(HIF-1α) expression and the apoptosis effect of hypoxia stimulated by cobalt chloride (CoCl<sub>2</sub>) in pancreatic cancer PC-2 cells.</p> <p>Methods</p> <p>PC-2 cells were cultured with different concentration (50-200 μmol/L) of CoCl<sub>2 </sub>after 24-120 hours to simulate hypoxia in vitro. The proliferation of PC-2 cells was examined by MTT assay. The cellular morphology of PC-2 cells were observed by light inverted microscope and transmission electron microscope(EM). The expression of HIF-1α on mRNA and protein level was measured by semi-quantitive RT-PCR and Western blot analysis. Apoptosis of PC-2 cells were demonstrated by flow cytometry with Annexin V-FITC/PI double staining.</p> <p>Results</p> <p>MTT assay showed that the proliferation of PC-2 cells were stimulated in the first 72 h, while after treated over 72 h, a dose- dependent inhibition of cell growth could be observed. By using transmission electron microscope, swollen chondrosomes, accumulated chromatin under the nuclear membrane and apoptosis bodies were observed. Flow cytometer(FCM) analysis showed the apoptosis rate was correlated with the dosage of CoCl<sub>2</sub>. RT-PCR and Western blot analysis indicated that hypoxia could up-regulate the expression of HIF-1α on both mRNA and protein levels.</p> <p>Conclusion</p> <p>Hypoxic microenvironment stimulated by CoCl<sub>2 </sub>could effectively induce apoptosis and influence cell proliferation in PC-2 cells, the mechanism could be related to up-expression of HIF-1α.</p
- …