A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease

Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have improved our understanding of the pathogenesis of multiple myeloma-induced bone disease and suggest several potential therapeutic strategies. However, the effectiveness of some potential therapeutic strategies still requires further investigation and optimization. In this paper, a recently developed mathematical model is extended to mimic and then evaluate three therapies of the disease, namely: bisphosphonates, bortezomib and TGF-β inhibition. The model suggests that bisphosphonates and bortezomib treatments not only inhibit bone destruction, but also reduce the viability of myeloma cells. This contributes to the current debate as to whether bisphosphonate therapy has an anti-tumour effect. On the other hand, the analyses indicate that treatments designed to inhibit TGF-β do not reduce bone destruction, although it appears that they might reduce the viability of myeloma cells, which again contributes to the current controversy regarding the efficacy of TGF-β inhibition in multiple myeloma-induced bone disease

Electromagnetic fields in a 3D cavity and in a waveguide with oscillating walls

We consider classical and quantum electromagnetic fields in a three-dimensional (3D) cavity and in a waveguide with oscillating boundaries of the frequency $\Omega$. The photons created by the parametric resonance are distributed in the wave number space around $\Omega/2$ along the axis of the oscillation. When classical waves propagate along the waveguide in the one direction, we observe the amplification of the original waves and another wave generation in the opposite direction by the oscillation of side walls. This can be understood as the classical counterpart of the photon production. In the case of two opposite walls oscillating with the same frequency but with a phase difference, the interferences are shown to occur due to the phase difference in the photon numbers and in the intensity of the generated waves.Comment: 8 pages revTeX including 1 eps fi

Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model

Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentiation of osteoclast precursors into mature osteoclasts, promoting osteoclast apoptosis and disrupting osteoclast function. However, it is still unclear whether bisphosphonates have an anti-tumour effect. In our previous work, a computational model was built to simulate the pathology of MM-induced bone disease. This paper extends this proposed computational model to investigate the efficacy of bisphosphonates treatment and then clear the controversy of this therapy. The extended model is validated through the good agreement between simulation results and experimental data. The simulation results suggest that bisphosphonates indeed have an anti-tumour effect

Chiral-Odd and Spin-Dependent Quark Fragmentation Functions and their Applications

We define a number of quark fragmentation functions for spin-0, -1/2 and -1 hadrons, and classify them according to their twist, spin and chirality. As an example of their applications, we use them to analyze semi-inclusive deep-inelastic scattering on a transversely polarized nucleon.Comment: 19 pages in Plain TeX, MIT CTP #221

Quark Orbital-Angular-Momentum Distribution in the Nucleon

We introduce gauge-invariant quark and gluon angular momentum distributions after making a generalization of the angular momentum density operators. From the quark angular momentum distribution, we define the gauge-invariant and leading-twist quark {\it orbital} angular momentum distribution $L_q(x)$. The latter can be extracted from data on the polarized and unpolarized quark distributions and the off-forward distribution $E(x)$ in the forward limit. We comment upon the evolution equations obeyed by this as well as other orbital distributions considered in the literature.Comment: 8 pages, latex, no figures, minor corrections mad

The Rotation Average in Lightcone Time-Ordered Perturbation Theory

We present a rotation average of the two-body scattering amplitude in the lightcone time($\tau$)-ordered perturbation theory. Using a rotation average procedure, we show that the contribution of individual time-ordered diagram can be quantified in a Lorentz invariant way. The number of time-ordered diagrams can also be reduced by half if the masses of two bodies are same. In the numerical example of $\phi^{3}$ theory, we find that the higher Fock-state contribution is quite small in the lightcone quantization.Comment: 25 pages, REVTeX, epsf.sty, 69 eps file

Novel theoretical approach in photoemission spectroscopy: application to isotope effect and boron-doped diamond

A new path-integral theory is developed to calculate the photoemission spectra (PES) of correlated many-electron systems. The application to the study on Bi2Sr2CaCu2O8 (Bi2212) and boron-doped diamond (BDD) is discussed in details. It is found that the isotopic shift in the angle-resolved photoemission spectra of Bi2212 is due to the off-diagonal quadratic electron-phonon (e-ph) coupling, whereas the presence of electron-electron repulsion partially suppresses this effect. For the BDD, a semiconductor-metal phase transition, which is induced by increasing the e-ph coupling and dopant concentration, is reproduced by our theory. Additionally, the presence of Fermi edge and phonon step-like structure in PES is found to be due to a co-existence of itinerant and localized electronic states in BDD.Comment: 6 pages, 4 figures, Procs. of LEHTSC 2007, submitted to J. Phys.: Conf. Se

Period halving of Persistent Currents in Mesoscopic Mobius ladders

We investigate the period halving of persistent currents(PCs) of non-interacting electrons in isolated mesoscopic M\"{o}bius ladders without disorder, pierced by Aharonov-Bhom flux. The mechanisms of the period halving effect depend on the parity of the number of electrons as well as on the interchain hopping. Although the data of PCs in mesoscopic systems are sample-specific, some simple rules are found in the canonical ensemble average, such as all the odd harmonics of the PCs disappear, and the signals of even harmonics are non-negative. {PACS number(s): 73.23.Ra, 73.23.-b, 68.65.-k}Comment: 6 Pages with 3 EPS figure