Remediation of Contaminated Soils by Solvent Flushing

Solvent flushing is a potential technique for remediating a waste disposal/spill site contaminated with organic chemicals. This technique involves the injection of a solvent mixture (e.g., water plus alcohols) that enhances contaminant solubility, reduces the retardation factor, and increases the release rates of the contaminants. A simulation model is developed to predict contaminant elution curves during solvent flushing for the case of one‐dimensional, steady flow through a contaminated medium. Column experiments are conducted with a Eustis fine sand that is initially equilibrated with an aqueous naphthalene solution, and then eluted with different methanol‐water mixtures to remove the naphthalene. The model simulations, based on parameter values estimated from literature data, agree well with the measured elution profiles. Solvent flushing experiments, where the soil was initially equilibrated with a solution of naphthalene and anthracene, show that compounds with different retardation factors are separated at low cosolvent contents, while coelution of the compounds occurs at higher contents. In general, the smaller the retardation factor in water and the higher the cosolvent fraction, the faster the contaminant is recovered. The presence of nonequilibrium conditions, soil heterogeneity, and type of cosolvent will influence the time required to recover the contaminant.\u

Regional differences in nutrient-induced secretion of gut serotonin

Enterochromaffin (EC) cells located in the gastrointestinal (GI) tract provide the vast majority of serotonin (5-HT) in the body and constitute half of all enteroendocrine cells. EC cells respond to an array of stimuli, including various ingested nutrients. Ensuing 5-HT release from these cells plays a diverse role in regulating gut motility as well as other important responses to nutrient ingestion such as glucose absorption and fluid balance. Recent data also highlight the role of peripheral 5-HT in various pathways related to metabolic control. Details related to the manner by which EC cells respond to ingested nutrients are scarce and as that the nutrient environment changes along the length of the gut, it is unknown whether the response of EC cells to nutrients is dependent on their GI location. The aim of the present study was to identify whether regional differences in nutrient sensing capability exist in mouse EC cells. We isolated mouse EC cells from duodenum and colon to demonstrate differential responses to sugars depending on location. Measurements of intracellular calcium concentration and 5-HT secretion demonstrated that colonic EC cells are more sensitive to glucose, while duodenal EC cells are more sensitive to fructose and sucrose. Short-chain fatty acids (SCFAs), which are predominantly synthesized by intestinal bacteria, have been previously associated with an increase in circulating 5-HT; however, we find that SCFAs do not acutely stimulate EC cell 5-HT release. Thus, we highlight that EC cell physiology is dictated by regional location within the GI tract, and identify differences in the regional responsiveness of EC cells to dietary sugars.Alyce M. Martin, Amanda L. Lumsden, Richard L. Young, Claire F. Jessup, Nick J. Spencer, Damien J. Keatin

Keeping Confidence: Responsibility and public health

Keeping Confidence: HIV and the criminal law from service provider perspectives Duration: June 2012 - March 2013 The Monument Trust generously funded Sigma Research at London School of Hygiene and Tropical Medicine and Birkbeck College to undertake a qualitative study on perceptions of criminal prosecutions for HIV transmission among HIV service providers. Five short reports outlining the key findings of the study focus on the main themes arising from our analysis of the focus group discussions. The findings and associated policy and practice recommendations will be of interest to: those who provide HIV health and social care and their professional bodies (for instance NHIVNA, CHIVA, BHIVA, BASHH, SSHA, BPS), police and others who play a role in criminal investigations and trials, and people with diagnosed HIV

Keeping Confidence: Practice and procedure

Keeping Confidence: HIV and the criminal law from service provider perspectives Duration: June 2012 - March 2013 The Monument Trust generously funded Sigma Research at London School of Hygiene and Tropical Medicine and Birkbeck College to undertake a qualitative study on perceptions of criminal prosecutions for HIV transmission among HIV service providers. Five short reports outlining the key findings of the study focus on the main themes arising from our analysis of the focus group discussions. The findings and associated policy and practice recommendations will be of interest to: those who provide HIV health and social care and their professional bodies (for instance NHIVNA, CHIVA, BHIVA, BASHH, SSHA, BPS), police and others who play a role in criminal investigations and trials, and people with diagnosed HIV

Keeping Confidence: Identifying resources

Keeping Confidence: HIV and the criminal law from service provider perspectives Duration: June 2012 - March 2013 The Monument Trust generously funded Sigma Research at London School of Hygiene and Tropical Medicine and Birkbeck College to undertake a qualitative study on perceptions of criminal prosecutions for HIV transmission among HIV service providers. Five short reports outlining the key findings of the study focus on the main themes arising from our analysis of the focus group discussions. The findings and associated policy and practice recommendations will be of interest to: those who provide HIV health and social care and their professional bodies (for instance NHIVNA, CHIVA, BHIVA, BASHH, SSHA, BPS), police and others who play a role in criminal investigations and trials, and people with diagnosed HIV. Catherine Dodds, Matthew Weait, Adam Bourne, Siri Egede, Kathie Jessup and Peter Weatherburn

Keeping Confidence: Understanding the Law

Keeping Confidence: HIV and the criminal law from service provider perspectives Duration: June 2012 - March 2013 The Monument Trust generously funded Sigma Research at London School of Hygiene and Tropical Medicine and Birkbeck College to undertake a qualitative study on perceptions of criminal prosecutions for HIV transmission among HIV service providers. Five short reports outlining the key findings of the study focus on the main themes arising from our analysis of the focus group discussions. The findings and associated policy and practice recommendations will be of interest to: those who provide HIV health and social care and their professional bodies (for instance NHIVNA, CHIVA, BHIVA, BASHH, SSHA, BPS), police and others who play a role in criminal investigations and trials, and people with diagnosed HIV

Vertical Boil Propagation from a Submerged Estuarine Sill

Surface disruptions by boils during strong tidal flows over a rocky sill were observed in thermal infrared imagery collected at the Snohomish River estuary in Washington State. Locations of boil disruptions and boil diameters at the surface were quantified and are used to test an idealized model of vertical boil propagation. The model is developed as a two-dimensional approximation of a three-dimensional vortex loop, and boil vorticity is derived from the flow shear over the sill. Predictions of boil disruption locations were determined from the modeled vertical velocity, the sill depth, and the over-sill velocity. Predictions by the vertical velocity model agree well with measured locations (rms difference 3.0 m) and improve by using measured velocity and shear (rms difference 1.8 m). In comparison, a boil-surfacing model derived from laboratory turbulent mixed-layer wakes agrees with the measurements only when stratification is insignificant

Turbulent Kinetic Energy and Coherent Structures in a Tidal River

We investigate the relationship between turbulence statistics and coherent structures (CS) in an unstratified reach of the Snohomish River estuary using in situ velocity measurements and surface infrared (IR) imaging. Sequential IR images are used to estimate surface flow characteristics via a particle-image-velocimetry (PIV) technique, and are conditionally sampled to delineate the surface statistics of bottom-generated CS, or boils. In the water column, we find that turbulent kinetic energy (TKE) production exceeds dissipation near the bed but is less than dissipation in the midwater column and that TKE flux divergence closes a significant portion of the measured imbalance. The surface boundary leads to divergence in upwelling CS, and leads to the redistribution of vertical TKE to the horizontal. Very near the surface, statistical anisotropy is observed at length scales larger than the depth H (3–5 m), while boil-scale motions of O(1)m are nearly isotropic and exhibit a 25/3 turbulent cascade to smaller scales. Conditional sampling suggests that TKE dissipation in boils is approximately 2 times greater on average than dissipation in ambient flow. Similarly, surface boils are marked by significantly greater velocity variance, upwelling, divergence, and TKE flux divergence than ambient flow regions. Coherent structures and their surface manifestation, therefore, play an important role in the vertical transport of TKE and the water column distribution of dissipation, and are an important component of the TKE budget