INDOT DM Chapter 204: “Post- Construction Stormwater BMPs”

INDOT has developed Chapter 204, “Post-Construction Stormwater Best Management Practices” (BMPs), in the Indiana Design Manual (IDM) to help the agency comply with IDEM stormwater and MS4 permit requirements. The BMPs are designed to prevent or reduce non-point source pollution to help achieve water quality goals. This presentation will provide the industry with a project update and an implementation plan for this new chapter

Protection of Karst Features During Project Development and Construction

INDOT released a new procedure in July 2021 to protect karst features during project development and construction. Three key components of the new procedure are: (1) an expanded Indiana Karst Region, (2) integration with other INDOT environmental procedures and federal and state environmental laws, and (3) an educational component that includes best management practices and karst geology and biology. This presentation will provide an overview of the procedure, implementation guidance, and key concepts

The Correlation between Confidence and Knowledge of Evidence-Based Practice among Occupational Therapy Students

Evidence-based practice (EBP) is used throughout multiple health-care professions and includes the use of best research available, client preferences, and the practitioner’s experience. Occupational therapy educational programs are required to incorporate EBP into their curriculum. A convenience sample of occupational therapy students from a private university completed a survey designed to measure students’ knowledge and confidence in EBP. The survey consisted of the Knowledge of Research Evidence Competencies (K-REC) and the Evidence-Based Practice Confidence (EPIC) scale, as well as demographic questions. Of the respondents (n = 47), third-year students indicated higher confidence in the ability to utilize EBP and higher levels of knowledge related to EBP than second- or first-year students. The more didactic and clinical experience that the students had, the more knowledge related to EBP they had, which increased their confidence in the implementation of EBP. The knowledge and confidence that students gain of EBP within their educational training and clinical experiences can influence their future use and implementation of EBP as clinicians. Without this information, therapists will lack the confidence and ability to apply EBP principles in a changing and demanding health-care environment

Multiple prebiotic metals mediate translation.

Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life's oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a functional ancestral state. First, SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) was used to compare the effect of Mg2+, Fe2+, and Mn2+ on the tertiary structure of rRNA. Then, we used in vitro translation reactions to test whether Fe2+ or Mn2+ could mediate protein production, and quantified ribosomal metal content. We found that (i) Mg2+, Fe2+, and Mn2+ had strikingly similar effects on rRNA folding; (ii) Fe2+ and Mn2+ can replace Mg2+ as the dominant divalent cation during translation of mRNA to functional protein; and (iii) Fe and Mn associate extensively with the ribosome. Given that the translation system originated and matured when Fe2+ and Mn2+ were abundant, these findings suggest that Fe2+ and Mn2+ played a role in early ribosomal evolution

Indigenous Evaluation 101 Guidebook

This Guide was developed by Bowman Performance Consulting and Wilder Research as part of our work with the Minnesota Department of Education to conduct an Indigenous Evaluation for Minnesota's Preschool Development Grant. It was developed to help the State of Minnesota, Indigenous organizations, and others to recognize the steps and considerations necessary to design and implement an evaluation that considers Indigenous ways of knowing. It contains concrete tips and tools, and includes links to other resources

ABERRANT TESTA SHAPE encodes a KANADI family member, linking polarity determination to separation and growth of Arabidopsis ovule integuments

The Arabidopsis aberrant testa shape (ats) mutant produces a single integument instead of the two integuments seen in wild-type ovules. Cellular anatomy and patterns of marker gene expression indicate that the single integument results from congenital fusion of the two integuments of the wild type. Isolation of the ATS locus showed it to encode a member of the KANADI (KAN) family of putative transcription factors, previously referred to as KAN4. ATS was expressed at the border between the two integuments at the time of their initiation, with expression later confined to the abaxial layer of the inner integument. In an inner no outer (ino) mutant background, where an outer integument does not form, the ats mutation led to amorphous inner integument growth. The kan1 kan2 double mutant exhibits a similar amorphous growth of the outer integument without affecting inner integument growth. We hypothesize that ATS and KAN1/KAN2 play similar roles in the specification of polarity in the inner and outer integuments, respectively, that parallel the known roles of KAN proteins in promoting abaxial identity during leaf development. INO and other members of the YABBY gene family have been hypothesized to have similar parallel roles in outer integument and leaf development. Together, these two hypotheses lead us to propose a model for normal integument growth that also explains the described mutant phenotypes

Feasibility and Preliminary Efficacy of Implementing a Group-Mediated Cognitive Behavioral Resistance Exercise Intervention in Head and Neck Cancer Patients Undergoing Chemoradiation Treatment

Head and neck cancer (HNCa) patients report some of the lowest quality of life (QOL) compared to other cancer populations, due to the clinically meaningful deficits in muscle mass, called cancer cachexia, and physical function that are associated with the established standard of care, which includes Chemoradiation therapy (CRT). PURPOSE: Determine the feasibility and preliminary efficacy of implementing a group-mediated cognitive behavioral (GMCB) resistance exercise (RE) intervention in HNCa patients undergoing CRT. METHODS: The HNCaRE study was a single-arm, pilot trial designed to evaluate the safety, feasibility, and preliminary efficacy of implementing a GMCB personalized RE intervention in nine HNCa patients undergoing CRT. Assessment of all functional, anthropometric, and patient-reported outcomes were obtained at baseline, 3-months, and 6-month follow-up visits. RESULTS: Findings from the initial cohort of the HNCaRE pilot trial (n=9) suggest that the GMCB RE intervention was a feasible, safe, and well-tolerated intervention for HNCa patients undergoing CRT. The Cohen’s d effect sizes were calculated by taking the mean difference and diving by the pooled standard deviation to determine the magnitude. Percent change was determined by calculating the mean difference from baseline at each assessment and dividing by the baseline value. Evaluation of the effect sizes and percent change indicate the RE intervention attenuated the deleterious effects that have been observed upon muscle mass (d=-0.74), physical function (d=0.28), and QOL (d=-0.65) previously among HNCa patients undergoing CRT. Patients who demonstrated the greatest adherence to the intervention sessions yielded the most favorable changes in these outcomes. CONCLUSION: Findings from the HNCaRE pilot trial provide evidence of the feasibility, safety, and preliminary efficacy of implementing a GMBC-based RE intervention among HNCa patients undergoing CRT. The RE intervention shows promise for countering the well-established deleterious effects upon body composition, physical function, and QOL accompanying CRT

A Rare Case of Double Belly Soleus Muscle

The rare anatomical anomaly of a double belly soleus muscle has been associated with some clinical and non-clinical correlations in patients. With symptomatic patients, usually not presenting until 20–30 years old, pain is exacerbated by long walks, running, and standing for long periods of time. This presentation could mimic the properties of a soft tissue tumor, thus misleading physicians. The discovery of the double belly soleus muscle is noticed while in surgery, biopsy, computed tomography scan, or magnetic resonance imaging machine. We herewith present a rare case of double belly soleus on the left and right posterior lower leg region of a 58-year-old female cadaver. This article will help bring awareness to the signs and symptoms of this rare anatomical anomaly

On ‘Organized Crime’ in the illicit antiquities trade: moving beyond the definitional debate

The extent to which ‘organized crime’ is involved in illicit antiquities trafficking is unknown and frequently debated. This paper explores the significance and scale of the illicit antiquities trade as a unique transnational criminal phenomenon that is often said to be perpetrated by and exhibit traits of so-called ‘organized crime.’ The definitional debate behind the term ‘organized crime’ is considered as a potential problem impeding our understanding of its existence or extent in illicit antiquities trafficking, and a basic progression-based model is then suggested as a new tool to move beyond the definitional debate for future research that may help to elucidate the actors, processes and criminal dynamics taking place within the illicit antiquities trade from source to market. The paper concludes that researchers should focus not on the question of whether organized criminals- particularly in a traditionally conceived, mafia-type stereotypical sense- are involved in the illicit antiquities trade, but instead on the structure and progression of antiquities trafficking itself that embody both organized and criminal dynamics