Adaptation of translational machinery in malaria parasites to accommodate translation of poly-adenosine stretches throughout its life cycle

Malaria is caused by unicellular apicomplexan parasites of the genu

Jessey Perovany to Susan Kean, June 2, 1799

Jessey Perovany wrote from Philadelphia, Pennsylvania to Susan Kean in Elizabethtown, New Jersey. Jessey was happy to hear that Peter made progress in French. She meant to write to him but her child had been sick with a severe cold that she attributed to being bathed in cold water. Planned to leave for Havana with Mr. Perovany. The only foreigners who had been received well in Havana were Perovany and the Princes of Orleans. Everybody advised Mr. Perovany to open an academy and Jessey also planned to open a school. She worried her money would not arrive in Havana and asked Susan if she could borrow money until she was settled.https://digitalcommons.kean.edu/lhc_1790s/1608/thumbnail.jp

Evidence in Neuroimaging: Towards a Philosophy of Data Analysis

Neuroimaging technology is the most widely used tool to study human cognition. While originally a promising tool for mapping the content of cognitive theories onto the structures of the brain, recently developed tools for the analysis, handling and sharing of data have changed the theoretical landscape of cognitive neuroscience. Even with these advancements philosophical analyses of evidence in neuroimaging remain skeptical of the promise of neuroimaging technology. These views often treat the analysis techniques used to make sense of data produced in a neuroimaging experiment as one, attributing the inferential limitations of analysis pipelines to the technology as a whole. Situated against the neuroscientists own critical assessment of their methods and the limitations of those methods, this skepticism appears based on a misunderstanding of the role data analysis techniques play in neuroimaging research. My project picks up here, examining how data analysis techniques, such as pattern classification analysis, are used to assess the evidential value of neuroimaging data. The project takes the form of three papers. In the first I identify the use of multiple data analysis techniques as an important aspect of the data interpretation process that is overlooked by critics. In the second I develop an account of inferences in neuroimaging research that is sensitive to this use of data analysis techniques, arguing that interpreting neuroimaging data is a process of isolating and explaining a variety of data patterns. In the third I argue that the development and uptake of new techniques for analyzing data must be accompanied by changes in research practices and standards of evidence if they are to promote knowledge generation. My approach to this work is both traditionally philosophical, insofar as it involves reading and analyzing the work of philosophers and neuroscientists, and embedded insofar as most of the research was conducted while engaged in attending lab meetings and participating in the work of those scientists whose work is the object of my research

Jessey Perovany to Susan Kean, June 27, 1799

Jessey Perovany wrote from Philadelphia, Pennsylvania to Susan Kean in Elizabethtown, New Jersey. Jessey apologized for her last request as it would grieve her exceedingly to have offended Susan. Planned to set sail in a few days. Her spirits were low and it was hard for her to write. Jessey learned Spanish so she could communicate with Havana locals.https://digitalcommons.kean.edu/lhc_1790s/1650/thumbnail.jp

Jessey Perovany to Susan Kean, November 25, 1799

Jessey Perovany wrote from Havana to Susan Kean, unaddressed. Perovany feared she did not receive her pardon for a request she made although it was with the best of intentions. She discussed a quarrel between her and a Spanish gentleman she had already given Susan an account of. They traveled together en route to Havana but stopped in Providence. Perovany pursued the remainder of the voyage alone on board an “old rotten Spanish schooner.” She had a baby boy and asked Susan to not tell her mother anything as she would “go down to the grave with sorrow” and her “old Calvinist friends” would hate and despise her. Perovany’s baby boy looked just like his father but had his mother’s eyes. The fifty dollars Susan lent was remitted three months prior as a bill of exchange of one hundred and fifty dollars, the one hundred for Perovany’s mother. She and Mr. Perovany extended their compliments to Mr. Niemcewitz. Satin sold in Havana extremely well and Perovany purchased a black one for church that cost sixty dollars. To be in fashion one must have had a massy bracelet of Spanish gold worn on the middle of the left arm, a chaplet of the same metal, and a superb fan that was valued at about two hundred dollars. Then, a lady entered church, kneeled, and sat on a fine carpet flat on the ground. Extended well wishes to Peter and mutual acquaintances. People mentioned: Julian Niemcewicz and Peter Keanhttps://digitalcommons.kean.edu/lhc_1790s/1628/thumbnail.jp

IMAGINING, PRACTICING AND CONTESTING ROAD DEVELOPMENT IN SOUTHERN WEST VIRGINIA, 1920S TO 1970S

Roads are ubiquitous yet few understand the historical and political geographies of their development. Politics, scale, and geographical imagination interweave in processes of promoting and building highways. This dissertation explores geographical imaginations of road development in West Virginia during the 1920s to 1970s with a focus on efforts to link the Great Lakes and Florida through southern West Virginia and southwestern Virginia. Due to its steep and uneven terrain the region is often viewed as remote and isolated, but it was considered an essential link between the Great Lakes and Florida. This research explores three phases of the region's highway development: the transition between named historic-scenic trails and the numbered U.S. Highway System in the 1920s and 1930s; the development of the highly contested West Virginia Turnpike in the 1950s; and the incorporation of the turnpike into the interstate highway system during the 1960s and 1970s. This research enlivens road development by examining demands for better highways and its contestation. West Virginians have a long history of vying for improved road space. To explore the complexities of road development I utilize a simple framework of materiality, meaning, and practice. The advantage of this trifold approach is that it uncovers imaginations of road development and its contestation at multiple scales ranging from national imaginaries to local road uses. I draw heavily on the concepts of kinaesthetics and rhythm to consider how envisioning and contesting road space were intertwined with popular understandings of driving and riding roads in historically and geographically contingent circumstances. Kinaesthetics, the awareness of one's body in motion, helps us uncover how driving deplorable roads was used as a political tool to encourage improvement. Rhythm is useful for exploring how roads were commodified and practiced

Jessey Perovany to Susan Kean, February 2, 1799

Jessey Perovany wrote from Philadelphia, Pennsylvania to Susan Kean in Elizabethtown, New Jersey. Jessey worried Susan considered her an ungrateful human being however, she was not to be blamed but pitied. For a long time, she was unable to collect her ideas and could not bring herself to write. As soon as Mr. Perovany recovered from his second illness, he prepared for his departure to Havana. He left the Tuesday prior. Jessey’s mind had been tortured with worry that this may have been the last time she saw her husband. Jessey added additional text dated January 10 and claimed it had been a long time since she wrote the above and had not written anyone in months, including her mother. At the moment, she was indisposed but imputed that to being pregnant. She had no desire to have any more children, especially if she had the misfortune to lose her companion. Mr. Perovany had the greatest probability of making money in Havana and Jessey planned to join him in May accompanied by a noble friend in whose care Mr. Perovany left her. Her friend did everything in his power to detain Mr. Perovany until they could all travel together but Mr. Perovany was too prudent to listen. She closed her letter quickly on account of being sick.https://digitalcommons.kean.edu/lhc_1790s/1645/thumbnail.jp

Jessey Perovany to Susan Kean, October 25, 1799

Jessey Perovany wrote from Germantown, Pennsylvania to Susan Kean in Elizabethtown, New Jersey. Perovany acknowledged the receipt of Susan’s letter and thanked her profusely for her assistance in lending her money. Charmed to hear Peter was feeling better and informed Susan she was pregnant. Had little information on Shosinsko, and his sudden departure stunned everyone. Appreciated that Susan shared so much information with her in her last letter since she had an antipathy toward writing.https://digitalcommons.kean.edu/lhc_1790s/1625/thumbnail.jp

Book Review: \u27My Dear Timothy by Victor Gollancz

A review of the book, My Dear Timothy, which was published by Simon & Schuster in 1953 and authored by Victor Gollancz

Book Review: \u27My Dear Timothy by Victor Gollancz

A review of the book, My Dear Timothy, which was published by Simon & Schuster in 1953 and authored by Victor Gollancz