35,058 research outputs found
Review of economic evidence in the prevention and early detection of colorectal cancer.
This paper aims to systematically review the cost-effectiveness evidence, and to provide a critical appraisal of the methods used in the model-based economic evaluation of CRC screening and subsequent surveillance. A search strategy was developed to capture relevant evidence published 1999-November 2012. Databases searched were MEDLINE, EMBASE, National Health Service Economic Evaluation (NHS EED), EconLit, and HTA. Full economic evaluations that considered costs and health outcomes of relevant intervention were included. Sixty-eight studies which used either cohort simulation or individual-level simulation were included. Follow-up strategies were mostly embedded in the screening model. Approximately 195 comparisons were made across different modalities; however, strategies modelled were often simplified due to insufficient evidence and comparators chosen insufficiently reflected current practice/recommendations. Studies used up-to-date evidence on the diagnostic test performance combined with outdated information on CRC treatments. Quality of life relating to follow-up surveillance is rare. Quality of life relating to CRC disease states was largely taken from a single study. Some studies omitted to say how identified adenomas or CRC were managed. Besides deterministic sensitivity analysis, probabilistic sensitivity analysis (PSA) was undertaken in some studies, but the distributions used for PSA were rarely reported or justified. The cost-effectiveness of follow-up strategies among people with confirmed adenomas are warranted in aiding evidence-informed decision making in response to the rapidly evolving technologies and rising expectations
Quantum Dot and Hole Formation in Sputter Erosion
Recently it was experimentally demonstrated that sputtering under normal
incidence leads to the formation of spatially ordered uniform nanoscale islands
or holes. Here we show that these nanostructures have inherently nonlinear
origin, first appearing when the nonlinear terms start to dominate the surface
dynamics. Depending on the sign of the nonlinear terms, determined by the shape
of the collision cascade, the surface can develop regular islands or holes with
identical dynamical features, and while the size of these nanostructures is
independent of flux and temperature, it can be modified by tuning the ion
energy
Quantum Dot and Hole Formation in Sputter Erosion
Recently it was experimentally demonstrated that sputtering under normal
incidence leads to the formation of spatially ordered uniform nanoscale islands
or holes. Here we show that these nanostructures have inherently nonlinear
origin, first appearing when the nonlinear terms start to dominate the surface
dynamics. Depending on the sign of the nonlinear terms, determined by the shape
of the collision cascade, the surface can develop regular islands or holes with
identical dynamical features, and while the size of these nanostructures is
independent of flux and temperature, it can be modified by tuning the ion
energy
Near-deterministic quantum teleportation and resource-efficient quantum computation using linear optics and hybrid qubits
We propose a scheme to realize deterministic quantum teleportation using
linear optics and hybrid qubits. It enables one to efficiently perform
teleportation and universal linear-optical gate operations in a simple and
near-deterministic manner using all-optical hybrid entanglement as off-line
resources. Our analysis shows that our new approach can outperforms major
previous ones when considering both the resource requirements and fault
tolerance limits.Comment: 10 pages, 5 figures; extended version, title, abstract and figures
changed, details added, to be published in Phys. Rev.
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