Decomposed entropy and estimation of output power in deformed microcavity lasers

Park et al. [Phys. Rev. A 106, L031504 (2022)] showed that the Shannon entropy of the probability distribution of a single random variable for far-field profiles (FFPs) in deformed microcavity lasers can efficiently measure the directionality of deformed microcavity lasers. In this study, we instead consider two random variables of FFPs with joint probability distributions and introduce the decomposed (Shannon) entropy for the peak intensity of directional emissions. This provides a new foundation such that the decomposed entropy can estimate the degree of the output power at given FFPs without any further information.Comment: 7 pages, 5 figure

Trustworthiness-Driven Graph Convolutional Networks for Signed Network Embedding

The problem of representing nodes in a signed network as low-dimensional vectors, known as signed network embedding (SNE), has garnered considerable attention in recent years. While several SNE methods based on graph convolutional networks (GCN) have been proposed for this problem, we point out that they significantly rely on the assumption that the decades-old balance theory always holds in the real-world. To address this limitation, we propose a novel GCN-based SNE approach, named as TrustSGCN, which corrects for incorrect embedding propagation in GCN by utilizing the trustworthiness on edge signs for high-order relationships inferred by the balance theory. The proposed approach consists of three modules: (M1) generation of each node's extended ego-network; (M2) measurement of trustworthiness on edge signs; and (M3) trustworthiness-aware propagation of embeddings. Furthermore, TrustSGCN learns the node embeddings by leveraging two well-known societal theories, i.e., balance and status. The experiments on four real-world signed network datasets demonstrate that TrustSGCN consistently outperforms five state-of-the-art GCN-based SNE methods. The code is available at https://github.com/kmj0792/TrustSGCN.Comment: 12 pages, 8 figures, 9 table

Observation and Numerical Prediction of 2011 East Japan Tsunami Inpacific Ocean

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration

Multipotent stem cells have the capacity to generate terminally differentiated cell types of each lineage; thus, they have great therapeutic potential for a wide variety of diseases. The most widely available stem cells are derived from human tissues, and their use for therapeutic application is limited by their high cost and low productivity. Herein, we report that conditioned media of mesenchymal stem cells (MSCs) isolated from deer antlers enhanced tissue regeneration through paracrine action via a combination of secreted growth factors and cytokines. Notably, DaMSC-conditioned media (DaMSC-CM) enhanced hair regeneration by activating the Wnt signaling pathway. In addition, DaMSC-CM had regenerative potential in damaged skin tissue through induction of skin regeneration-related genes. Remarkably, we identified round vesicles derived from DaMSC-CM, with an average diameter of ~120 nm that were associated with hair follicle formation, suggesting that secretory vesicles may act as paracrine mediators for modulation of local cellular responses. In addition, these secretory vesicles could regulate the expression of Wnt-3a, Wnt-10b, and lymphoid enhancer-binding factor-1 (LEF-1), which are related to tissue renewal. Thus, our findings demonstrate that the use of DaMSC-CM as a unique natural model for rapid and complete tissue regeneration has possible application for therapeutic development

Comparison of Laparoendoscopic Single-Site Radical Nephrectomy with Conventional Laparoscopic Radical Nephrectomy for Localized Renal-Cell Carcinoma

Purpose: To compare the results of laparoendoscopic single-site (LESS) radical nephrectomy with conventional laparoscopic radical nephrectomy for localized renal-cell carcinoma (RCC). Patients and Methods: This study was designed as a matched case-controlled study from our institute`s RCC database. Nineteen consecutive patients who were undergoing LESS radical nephrectomy were compared with 38 patients who were undergoing conventional laparoscopic radical nephrectomy. The matching process accounted for sex, age, operative side, and tumor size. Results: No significant differences were observed in mean operative time (190.8 vs 172.4 min, P - 0.249), estimated blood loss (143.2 vs 199.5 mL, P - 0.235), and complication rate (15.8% vs 21.1 %, P - 0.635) between the LESS and conventional laparoscopy groups. Postoperative hospital stay after LESS radical nephrectomy was 2.7 (2-4) days, compared with 3.9 (3-7) days in the conventional laparoscopy group (P < 0.001). Postoperative pain, as measured by visual analog scale at postoperative day 1 (4.7 vs 5.8 points, P - 0.001), 2 (3.4 vs 4.6 points, P < 0.001), and 3 (2.7 vs 4.0 points, P = 0.008) was significantly lower in the LESS group. Conclusion: LESS radical nephrectomy is a feasible and safe surgical option for localized RCC that demonstrates improved cosmetic outcomes and the additional benefits of decreased postoperative pain and decreased hospital stay.Desai MM, 2009, UROLOGY, V74, P805, DOI 10.1016/j.urology.2009.02.083Stolzenburg JU, 2009, EUR UROL, V56, P644, DOI 10.1016/j.eururo.2009.06.022Stolzenburg JU, 2009, J ENDOUROL, V23, P1287, DOI 10.1089/end.2009.0120Raman JD, 2009, EUR UROL, V55, P1198, DOI 10.1016/j.eururo.2008.08.019Park YH, 2009, J ENDOUROL, V23, P833, DOI 10.1089/end.2009.0025Kommu SS, 2009, BJU INT, V103, P1034, DOI 10.1111/j.1464-410X.2008.08282.xRAYBOURN JH, 2009, UROLOGY 0721Canes D, 2008, EUR UROL, V54, P1020, DOI 10.1016/j.eururo.2008.07.009Bandi G, 2008, BJU INT, V101, P459, DOI 10.1111/j.1464-410X.2007.07235.xDELGADO S, 2008, GASTROENTEROL HEPATO, V31, P515Raman JD, 2007, UROLOGY, V70, P1039, DOI 10.1016/j.urology.2007.10.001Colombo JR, 2007, CLINICS, V62, P251Hemal AK, 2007, J UROLOGY, V177, P862, DOI 10.1016/j.juro.2006.10.053Kawauchi A, 2007, UROLOGY, V69, P53, DOI 10.1016/j.urology.2006.09.009KAVOUSSI LR, 1993, UROLOGY, V42, P603CLAYMAN RV, 1991, J UROLOGY, V146, P2781

Role of lymphatic invasion in predicting biochemical recurrence after radical prostatectomy

ObjectiveLymphatic invasion in prostate cancer is associated with poor prognosis. However, there is no consensus regarding the clinical and prognostic value of lymphatic invasion. This study aimed to investigate the prognostic value of lymphatic invasion in biochemical recurrence (BCR) and compare the recurrence rates between patients with lymphatic invasion and lymph node metastasis.MethodsWe retrospectively analyzed 2,207 patients who underwent radical prostatectomy (RP) without pelvic lymph node dissection (PLND) and 742 patients who underwent RP with PLND for clinically localized or locally advanced prostate cancer, between 1993 and 2020, at Seoul National University Hospital. Kaplan–Meier analysis was performed to estimate BCR-free survival (BCRFS) using the log-rank test. The Cox proportional hazards model was used to identify the significant factors for BCR. Propensity score matching was performed with a 1:2 ratio to match age, initial PSA level, pathological T stage, and Gleason score to exclude confounding effects.ResultsOf the 2,207 patients who underwent RP without PLND, lymphatic invasion (L1Nx) was observed in 79 (3.5%) individuals. Among the 742 patients who underwent RP with PLND, lymph node metastases were found in 105 patients (14.2%). In patients with lymph node metastasis, lymphatic invasion was observed in 50 patients (47.6%), whereas lymphatic invasion was observed in 53 patients (8.3%) among those without lymph node metastasis. In patients who underwent RP without PLND, Kaplan–Meier analysis showed significantly poorer BCR-free survival in the L1Nx group than in the L0Nx group (p &lt; 0.001). In patients who underwent RP with PLND, the L1N0, L0N1, and L1N1 groups showed significantly worse prognoses than the L0N0 group (p &lt; 0.001). However, there was no significant difference in BCRFS between the L1N0 and lymph node metastasis groups, including the L0N1 and L1N1 groups. After propensity score matching at a 1:2 ratio, the L1Nx group showed significantly poorer outcomes in terms of BCRFS than the L0Nx group (p = 0.05). In addition, the L1N0 group showed a significantly worse prognosis than the L0N0 group after propensity score matching.ConclusionLymphatic invasion in radical prostatectomy specimens is an independent prognostic factor, which can complement lymph node status for predicting biochemical recurrence. Considering lymphatic invasion as an adverse pathological finding, similar to lymph node metastasis, adjuvant therapy could be considered in patients with lymphatic invasion

Polygenic risk score model for renal cell carcinoma in the Korean population and relationship with lifestyle-associated factors

Background The polygenic risk score (PRS) is used to predict the risk of developing common complex diseases or cancers using genetic markers. Although PRS is used in clinical practice to predict breast cancer risk, it is more accurate for Europeans than for non-Europeans because of the sample size of training genome-wide association studies (GWAS). To address this disparity, we constructed a PRS model for predicting the risk of renal cell carcinoma (RCC) in the Korean population. Results Using GWAS analysis, we identified 43 Korean-specific variants and calculated the PRS. Subsequent to plotting receiver operating characteristic (ROC) curves, we selected the 31 best-performing variants to construct an optimal PRS model. The resultant PRS model with 31 variants demonstrated a prediction rate of 77.4%. The pathway analysis indicated that the identified non-coding variants are involved in regulating the expression of genes related to cancer initiation and progression. Notably, favorable lifestyle habits, such as avoiding tobacco and alcohol, mitigated the risk of RCC across PRS strata expressing genetic risk. Conclusion A Korean-specific PRS model was established to predict the risk of RCC in the underrepresented Korean population. Our findings suggest that lifestyle-associated factors influencing RCC risk are associated with acquired risk factors indirectly through epigenetic modification, even among individuals in the higher PRS category. Keywords Polygenic risk score, Genome-wide association study, Renal cell carcinoma, Korean population, Noncoding variant, Epigenetics, Lifestyle-associated factorThis study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (HA17C0039) and the Cooperative Research Program of Basic Medical Science and Clinical Science from Seoul National University College of Medicine (800-20220315)

Are urothelial carcinomas of the upper urinary tract a distinct entity from urothelial carcinomas of the urinary bladder? Behavior of urothelial carcinoma after radical surgery with respect to anatomical location: a case control study

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.Abstract Background To compare the prognosis of upper urinary tract (UUT)-urothelial carcinoma (UC) and UC of the bladder (UCB) by pathological staging in patients treated with radical surgeries. Methods The study population comprised 335 and 302 consecutive radical surgery cases performed between 1991 and 2010 for UUT-UC and UCB, respectively. Five-year recurrence-free survival (RFS) and cancer-specific survival (CSS) rates were analyzed. The median follow-up period of all subjects was 59.3 months (range, 0.1–261.0 months). Results No difference was observed in median patient age, distribution of pathologic T stage, or rates of positive surgical margin between the two groups. The UUT-UC group had significantly more frequent hydronephrosis than the USB group (48.1% vs. 20.2%, p < 0.001). However, the UUT-UC group showed significantly less frequent grade III tumors (28.1% vs. 58.6%, p < 0.001), lymphovascular invasion (18.8% vs. 35.8%, p < 0.001), and associated carcinoma in situ (9.0% vs. 21.9%, p < 0.001) than the UCB group. Five year RFS rates in the UUT-UC and UCB groups were 77.0% and 75.9%, respectively (p = 0.546). No significant difference in RFS rate was observed between pathological T stage subgroups. Five year CSS rates in the UUT-UC and UCB groups were 76.1% and 76.2%, respectively (p = 0.462). No significant difference was observed in CSS rate between the pathologic T stage subgroups. Conclusions UUT-UC and UCB showed comparable prognosis at identical stages. However, our results should be verified in a prospective study due to the retrospective study design in this study