Characterising musical gestures

Despite the widespread use of the term gesture in writings about music, the term is not defined in most musical dictionaries. Moreover, as this paper shows, the term is employed by different writers in a wide variety of ways. One common use of the term refers to sonic instances that are close analogies of physical gestures. These could be termed expressive unit gestures which, like physical gestures, are perceived as a short, unified, expressive events. To enable a more detailed study of these, this paper outlines a systematic approach to their description in the hope that these will open possibilities for a more detailed study of this aspect of musical gestures. The HamNoSys notation was developed for the systematic description of sign language. Gestures of sign language are notated through a systematic profiling of the actions involved (hand shapes, movement types, etc.). By analogy a musical gesture can be described through its auditory properties such as accent patterns, pitch contour, register, and so forth. This paper suggests that studying these expressive unit gestures offers a way of linking the dynamics of the music with expressive potential and can, therefore, contribute to an experiential account of music; could lead to new methods of investigating listeners engagement with music; and could potentially offer new ideas in the field of music information retrieval

Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer's disease

Mannan-binding lectin (MBL) is a serum lectin which can activate the classical complement pathway. Complement proteins of the classical pathway have been found in the brains of patients with Alzheimer's disease (AD) in association with AD brain pathology. To investigate the role for MBL in AD we have looked for its presence in the brain by immunohistochemistry and determined the levels of MBL in paired samples of cerebrospinal fluid and serum from AD patients and controls. MBL was detected in association with blood vessels in the brain tissue of both AD patients and control subjects. There was no apparent difference in the distribution of MBL in the brain tissue between the two groups. The mean concentration of MBL in the CSF was 44% lower in AD patients than in controls (AD 154 ± 35 pg/ml, n = 19; non- AD 276 ± 50 pg/ml, n = 15, p &lt; 0.05). The levels of MBL in serum were not significantly different in the two groups. Thus, this study shows that MBL is associated with blood vessels in the brains of both AD and control subjects. Moreover, CSF levels of MBL appear to be lower in AD patients than in control subjects which may indicate a higher degree of MBL consumption connected with complement activation in the AD patients.</p