2,656 research outputs found
Difference system for Selberg correlation integrals
The Selberg correlation integrals are averages of the products
with respect to the Selberg
density. Our interest is in the case , , when this
corresponds to the -th moment of the corresponding characteristic
polynomial. We give the explicit form of a matrix linear
difference system in the variable which determines the average, and we
give the Gauss decomposition of the corresponding matrix.
For a positive integer the difference system can be used to efficiently
compute the power series defined by this average.Comment: 21 page
Localization of epigenetic markers in Leishmania chromatin
Eukaryotes use histone variants and post-translation modifications (PTMs), as well as DNA base modifications, to regulate DNA replication/repair, chromosome condensation, and gene expression. Despite the unusual organization of their protein-coding genes into large polycistronic transcription units (PTUs), trypanosomatid parasites also employ a histone code to control these processes, but the details of this epigenetic code are poorly understood. Here, we present the results of experiments designed to elucidate the distribution of histone variants and PTMs over the chromatin landscape o
Age- and Sex-Associated Effects on Acute-Phase Proteins in Göttingen Minipigs
Göttingen minipigs are a useful model for diseases having an inflammatory component, and the associated use of acute-phase proteins (APP) as biomarkers of inflammation warrants establishment of their reference ranges. The objective of this study was to establish reference values for selected APP in Göttingen minipigs and to investigate the effects of age, sex, and various stimuli on these ranges. Serum concentrations of C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin, pig major acute-phase protein (PMAP), albumin, and porcine α-1 acid glycoprotein (PAGP) were evaluated in 4 age groups (6, 16, 24 and 40â48 wk) of male and female Göttingen minipigs. In addition, minipigs were tested under 2 housing conditions, after acute LPS challenge, and after diet-induced obesity with and without mild diabetes. Changing the pigs to a new environment induced significant increases in CRP, PMAP, haptoglobin and PAGP and a decrease in albumin. An acute LPS stimulus increased CRP, PMAP, haptoglobin, and SAA; PAGP was unchanged and albumin decreased. Obese pigs with and without diabetes showed increases in CRP and PAGP, albumin decreased, and haptoglobin and SAA were unchanged. PMAP was increased only in obese pigs without diabetes. In conclusion, reference values for CRP, PMAP, haptoglobin, SAA, PAGP and albumin were established for male and female Göttingen minipigs of different ages. These APP were influenced by age and sex, underlining the importance of considering these factors when designing and interpreting studies including aspects of inflammation. In addition, an APP response was verified after both acute and chronic stimuli
Kinematics of Spiral Arm Streaming in M51
We use CO and H alpha velocity fields to study the gas kinematics in the
spiral arms and interarms of M51 (NGC 5194), and fit the 2D velocity field to
estimate the radial and tangential velocity components as a function of spiral
phase (arm distance). We find large radial and tangential streaming velocities,
which are qualitatively consistent with the predictions of density wave theory
and support the existence of shocks. The streaming motions are complex, varying
significantly across the galaxy as well as along and between arms. Aberrations
in the velocity field indicate that the disk is not coplanar, perhaps as far in
as 20\arcsec\ (800 pc) from the center. Velocity profile fits from CO and H
alpha are typically similar, suggesting that most of the H alpha emission
originates from regions of recent star formation. We also explore vortensity
and mass conservation conditions. Vortensity conservation, which does not
require a steady state, is empirically verified. The velocity and density
profiles show large and varying mass fluxes, which are inconsistent with a
steady flow for a single dominant global spiral mode. We thus conclude that the
spiral arms cannot be in a quasi-steady state in any rotating frame, and/or
that out of plane motions may be significant.Comment: 50 pages, including 20 figures; Accepted for publication in ApJ. PDF
version with high resolution figures available at
http://www.astro.umd.edu/~shetty/Research
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