Spectroscopic approaches to resolving ambiguities of hyper-polarized NMR signals from different reaction cascades

Ambiguities in identifying transient intracellular reaction intermediates are resolved by site-specific isotope labelling, optimised referencing and response to external perturbations.</p

Hyperpolarised Organic Phosphates as NMR Reporters of Compartmental pH

When formed in defined cellular compartments from exogenous hyperpolarised13C substrates, metabolites yield correlations of compartmental pH and catalytic activity.</p