Additional file 1: of Association between drug intake and incidence of malignancies in patients with Juvenile Idiopathic Arthritis: a nested case–control study

Intake and duration of rheumatic drugs. (DOCX 28 kb

Overall comparison of problems in EQ5D domains between JIA patients and the German general population^a.

<p>Overall comparison of problems in EQ5D domains between JIA patients and the German general population<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153267#t003fn002" target="_blank">^a</a>.</p

Health-related quality of life in JIA patients and the general German population.

<p>Age and gender standardized prevalence of problems in the five EQ5D dimensions with 95% confidence intervals.</p

Additional file 2: Table S2. of Education and employment in patients with juvenile idiopathic arthritis – a standardized comparison to the German general population

Crude and age and sex-standardized comparison of the employment status of the SEPIA study population admitted to the GCPAR before 2001 and the German General Population. (DOCX 32 kb

Additional file 3: Table S3. of Education and employment in patients with juvenile idiopathic arthritis – a standardized comparison to the German general population

Crude and age- and sex-standardized comparison of the unemployment rate of the SEPIA study population and the Bavarian General Population. (DOCX 38 kb

Inclusion of study participants.

<p>Inclusion of study participants.</p

Age and gender stratified comparison of the EQ5D domains between JIA patients and the German general population^a.

<p>Age and gender stratified comparison of the EQ5D domains between JIA patients and the German general population<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153267#t002fn002" target="_blank">^a</a>.</p

Incidence of malignancies in patients with juvenile idiopathic arthritis: A retrospective single-center cohort study in Germany

<p><i>Objectives</i>: In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population.</p> <p><i>Methods</i>: A retrospective single-center hospital-based cohort study was performed using data on the JIA patients treated between 1952 and 2010 at the German Center for Pediatric and Adolescent Rheumatology (GCPAR) (Garmisch-Partenkirchen, Germany). Self-administered standardized questionnaires were sent out in 2012. Standardized incidence ratios (SIRs) and their corresponding 95% confidence intervals (95%CIs) were calculated.</p> <p><i>Results</i>: The study cohort consisted of 3691 JIA patients, and the response rate was 66%. Patients age ranged from 3 to 73 years of which 64% were female. Total follow-up time was 60,075 person-years; a history of malignancy was reported by 47 patients. Most common types of cancer were melanoma (<i>n</i> = 11), cervical cancer (<i>n</i> = 8) and breast cancer (<i>n</i> = 7). The overall SIR for women was 1.19 (95%CI: 0.77; 1.60) and for men was 0.67 (95%CI: 0.27; 1.07). The SIR for melanoma was 3.21 (95%CI: 1.60; 5.73) in women, whereas in men no melanoma cases were observed.</p> <p><i>Conclusion</i>: Although no overall increased cancer risk was found, results suggest that the risk of melanoma might be increased in female JIA patients.</p

Associations between general and disease specific factors and HRQOL in JIA patients. Results of bivariate analyses and logistic regression models with EQ5D_Index as Outcome.

<p>Associations between general and disease specific factors and HRQOL in JIA patients. Results of bivariate analyses and logistic regression models with EQ5D_Index as Outcome.</p

Additional file 1: Table S1. of Education and employment in patients with juvenile idiopathic arthritis – a standardized comparison to the German general population

Age- and sex-standardized comparison of the educational achievements of the study population admitted to the GCPAR before 2001 and the GGP. (DOCX 49 kb