THE EFFECT OF PASSIVE AND ACTIVE IMPULSE ON THE PERFORMANCES OF DROP JUMPS

This experiment is to investigate the ground reaction forces of lhree diHerent heights of drop-jumps (DJ) in order to understand the eHect of passive and active impulses on the performance of DJ. Eleven subjects were asked to perform DJs. AMIT force-platform and penny electrical gonia-meter were used to record the ground reaction forces and knee angular displacement. After treating the data and discussion, the conclusions were obtained. The active force as well as the active impulse are that of DJ20=DJ40=DJ60 whose result is consistent with the flight-height of these three diHerent DJ. On the other hand, the higher the jump-altitude is, the larger the passive impulse and passive force are. This result is very diHerent from that of flight-height, so the passive impulsive seems to have no help to prompt the performances of DJs. After further examination of the ground reaction force, we found that the key determinant process is the PARFD that slopes down as the jump-heights increase. The DJ60 induces the largest passive impulse but also accompanies negative PARFD. On other hand, the DJ20 induces the smallest passive impulse but accompanies positive PARFD. Finally, the performances of DJ20, DJ40 and DJ60 have no diHerence

THE REGULATION OF LEG STIFFNESS AND EMG ACTIVITIES ON PERSON WITH VISUAL IMPAIRED DURING STEP-DOWN WALKING

The purpose of present study was to evaluate leg muscular regulation and neuromuscular activation by investigating the stiffness and EMG amplitude of normal vision students and visually impaired students. 10 normal vision (age: 24.3±20 years; height: 171.5±4.6cm; mass: 65.9±8.0kg) and 10 visually impaired students (age: 23.2±2.4 years; height: 163.4±9.6cm; mass: 62.8±15.0kg) were served as subjects. AMTI force platform (1200 Hz), Peak Performance motion analysis system (60Hz) and Biovision EMG system were used synchronously to record the ground reaction force, the kinematic parameters and EMG signals of lower extremity during the subjects stepped down from height 20, 30 and 40cm. The results revealed that the regulation of neuromuscular system of the impaired is less efficient compared to the normal one because of lower muscle stiffness and EMG activity

Biomechanical Characteristics and EMG Activities of Weighted Countermovement Jump

The purpose of this study was to investigate the biomechanical characteristics and EMG activities during a weighted countermovement jump (WCMJ) with 0%, 25% and 50% of body weight. Eight male college students participated this study. An AMTI force platform, Penny&Giles goniometer and Biovision EMG system were used synchronously to record the related parameters while subjects performed WCMJs. The results indicate that by increasing load, the eccentric mean force, the maximum force and concentric impulse increases significantly. With the load increase, the EMG activities of soleus and gastrocnemius did not changed significantly, while the eccentric mean EMG amplitude of rectus femoris got greater. This reveals that WCMJ has a marked influence on the lower extremity, especially on the rectus femoris

Association between copy number variation of complement component C4 and Graves' disease

<p>Abstract</p> <p>Background</p> <p>Gene copy number of complement component <it>C4</it>, which varies among individuals, may determine the intrinsic strength of the classical complement pathway. Presuming a major role of complement as an effecter in peptide-mediated inflammation and phagocytosis, we hypothesized that <it>C4 </it>genetic diversity may partially explain the development of Graves' disease (GD) and the variation in its outcomes.</p> <p>Methods</p> <p>A case-control study including 624 patients with GD and 160 healthy individuals were enrolled. CNV of <it>C4 </it>isotypes (<it>C4A </it>and <it>C4B</it>) genes were performed by quantitative real-time polymerase chain reaction analysis. Statistical comparison and identification of CNV of total <it>C4, C4 </it>isotypes (<it>C4A </it>and <it>C4B</it>) and <it>C4 </it>polymorphisms were estimated according to the occurrence of GD and its associated clinical features.</p> <p>Results</p> <p>Individuals with 4, 2, and 2 copies of <it>C4</it>, <it>C4A </it>and <it>C4B </it>genes, especially those with A2B2 polymorphism may associate with the development of GD (p = 0.001, OR = 10.994, 95% CI: 6.277-19.255; p = 0.008, OR = 1.732, 95% CI: 1.190-2.520; p = 2.420 × 10-5, OR = 2.621, 95% CI: 1.791-3.835; and <it>p </it>= 1.395 × 10^-4, OR = 2.671, 95% CI: 1.761-4.052, respectively). Although the distribution of copy number for total <it>C4</it>, <it>C4 </it>isotypes as well as <it>C4 </it>polymorphisms did not associate with the occurrence of goiter, nodular hyperplasia, GO and myxedema, <2 copies of <it>C4A </it>may associate with high risk toward vitiligo in patients with GD (<it>p </it>= 0.001, OR = 5.579, 95% CI: 1.659-18.763).</p> <p>Conclusions</p> <p>These results may be further estimated for its clinical application on GD and the vitiligo in patients with GD.</p

A case of acute appendicitis with Vibrio fluvialis peritonitis

AbstractHuman infections caused by Vibrio fluvialis are rarely reported. The most common clinical presentation of V. fluvialis infection is acute gastroenteritis with diarrhea. Reported extra-intestinal infections caused by V. fluvialis have included bacteremia, hemorrhagic cellulitis and cerebritis. Peritonitis is an uncommon clinical presentation of Vibrio infections, and most cases have occurred in patients receiving peritoneal dialysis or those with liver cirrhosis. Herein, we report the first case of acute appendicitis with V. fluvialis peritonitis

The Yang-Tonifying Herbal Medicine Cynomorium songaricum

Aging is highly correlated with the progressive loss of physiological function, including cognitive behavior and reproductive capacity, as well as an increased susceptibility to diseases; therefore, slowing age-related degeneration could greatly contribute to human health. Cynomorium songaricum Rupr. (CS) is traditionally used to improve sexual function and treat kidney dysfunction in traditional Chinese medicine, although little is known about whether CS has effects on longevity. Here, we show that CS supplementation in the diet extends both the mean and maximum lifespan of adult female flies. The increase in lifespan with CS was correlated with higher resistance to oxidative stress and starvation and lower lipid hydroperoxides (LPO) levels. Additionally, the lifespan extension was accompanied by beneficial effects, such as improved mating readiness, increased fecundity, and suppression of age-related learning impairment in aged flies. These findings demonstrate the important antiaging effects of CS and indicate the potential applicability of dietary intervention with CS to enhance health and prevent multiple age-related diseases

Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and dyslipidemia. The abnormalities in nutrient metabolism and elevated inflammatory mediators resulting from DM lead to impairment of wound healing and vulnerability to infection and foot ulcers. Diabetic lower limb ischemia often leads to limb necrosis. Lower extremity bypass surgery (LEBS) is indicated to prevent limb loss in patients with critical leg ischemia. This study investigated the alteration of inflammatory and endothelium dysfunction markers before and after LEBS in DM patients. Twenty one type 2 DM patients with LEBS were included. Blood was drawn before and at 1 day and 7 days after surgery in the patients. Plasma soluble cellular adhesion molecule levels and blood leukocyte integrin expressions were measured. Also, plasma concentrations of endothelin-1 and nitric oxide were analyzed to evaluate the vascular endothelial function. The results showed that there were no significant differences in plasma cellular adhesion molecules, endothelin-1 and nitric oxide levels, nor did any differences in leukocyte integrin expressions before and after the operation. These results suggest that the efficacy of LEBS on alleviating inflammatory reaction and improving endothelial function in DM patients was not obvious

The Protection of Hepatocyte Cells from the Effects of Oxidative Stress by Treatment with Vitamin E in Conjunction with DTT

We investigated the effect of vitamin E on membrane protein thiols under oxidative stress, which we induced by treating hepatocytes with tert-butyl hydroperoxide (TBH) for 60 mins. Those cells which we pretreated with vitamin E formed fewer blebs (22.3% compared to 60.0% in nonvitamin E-treated cells) and maintained cytosolic calcium concentration and the number of membrane protein thiols instead of showing the usual symptoms in cells undergoing oxidative stress. Dithiothreitol (DTT) also commonly reduces bleb formation in hepatocytes affected by TBH. However, our experiments clearly demonstrate that DTT does not prevent the changes in cytosolic calcium and membrane protein thiols in the blebbing cells. Consequently, we decided to pretreat cells with both DTT and vitamin E and found that the influence of TBH was entirely prevented. These findings may provide us with a new aspect for investigating the mechanism of bleb formation under oxidative stress