Fraternity Membership and Binge Drinking

This paper examines the relationship between membership in social fraternities and sororities and binge drinking among 18–24 year old full-time four-year college students who participated in the 1995 National College Health Risk Behavior Survey. To deal with unobserved heterogeneity in binge drinking incidence and frequency regressions, I enter as explanatory variables various measures of situational and overall alcohol use. When these are added, the fraternity membership coefficient is substantially reduced in size, but remains large and highly significant. This suggests that fraternity membership increases binge drinking. If not, it identifies a very specific mechanism underlying the decision to join a fraternity: members drink more intensely than non-members even while doing so in similar frequencies and situations and for similar lengths of time. Particularly notable is that behavior by underage students appears to drive the relationship.

Still the Economy, Stupid: Economic Voting in the 2004 Presidential Election

Given President Bush's popularity among relatively poor rural residents and lack thereof among wealthier urban dwellers in the 2004 presidential election, analysts have suggested that voters contradicted their economic self-interests. We investigate whether this conventional wisdom implied an absence of economic voting. Using exit poll data, we estimate whether a change in previous four-year financial status affected the propensity to vote for Bush. The main econometric concern is that underlying preferences for Bush might dictate financial status change responses. Beyond income and several other demographic variables, therefore, the regressions hold constant indicators for state and congressional district, religious affiliation, political philosophy and party, and Iraq war support. Even further controlling for approval of Bush's job performance, economic voting is statistically and quantitatively significant. Effects are asymmetric, with status worsening hurting Bush more than status improvement helped, and persist even among subgroups that provided particularly strong or weak support for Bush.

Binge Drinking & Sex in High School

This paper estimates the impact of binge drinking on sexual activity among a nationally representative set of high school students during the 1990s and 2000s. The main innovations are explicitly controlling for time-invariant preferences regarding sexual behavior and alcohol use, and eliminating non-drinkers from the comparison group. I find that binge drinking significantly increases participation in sex, promiscuity, and the failure to use birth control, albeit by amounts considerably smaller than implied by merely conditioning on exogenous factors. For all outcomes, impacts rise substantially with binge drinking frequency. Results are similar using alternative comparison groups defined by excluding those who do not exhibit other risky behaviors, and by gender and race/ethnicity, but vary by grade level and over time in different ways for engaging in sex than protective behavior. Effects are much larger for the small fraction of students that has not been taught about AIDS/HIV infection in school.

The Impact of Employment during School on College Student Academic Performance

This paper estimates the effect of paid employment on grades of full-time, four-year students from four nationally representative cross sections of the Harvard College Alcohol Study administered during 1993-2001. The relationship could be causal in either direction and is likely contaminated by unobserved heterogeneity. Two-stage GMM regressions instrument for work hours using paternal schooling and being raised Jewish, which are hypothesized to reflect parental preferences towards education manifested in additional student financial support but not influence achievement conditional on maternal schooling, college and class. Extensive empirical testing supports the identifying assumptions of instrument strength and orthogonality. GMM results show that an additional weekly work hour reduces current year GPA by about 0.011 points, roughly five times more than the OLS coefficient but somewhat less than recent estimates. Effects are stable across specifications, time, gender, class and age, but vary by health status, maternal schooling, religious background and especially race/ethnicity.

Binge Drinking and Risky Sex among College Students

This study examines the relationship between binge drinking and sexual behavior in nationally representative data on age 18–24 four-year college students. For having sex, overall or without condoms, large and significant positive associations are eliminated upon holding constant proxies for time-invariant sexual activity and drinking preferences. However, strong relationships persist for sex with multiple recent partners, overall and without condoms, even controlling for substance use, risk aversion, mental health, sports participation, and sexual activity frequency. Promiscuity is unrelated with non-binge drinking but even more strongly related with binge drinking on multiple occasions. Results from a rudimentary instrumental variables strategy and accounting for whether sex is immediately preceded by alcohol use suggest that binge drinking directly leads to risky sex. Some binge drinking-induced promiscuity seems to occur among students, especially males, involved in long-term relationships. Effects are concentrated among non-Hispanic whites and are not apparent for students in two-year schools.

Fraternity Membership & Frequent Drinking

Reinforcing earlier findings from other data, college senior fraternity/sorority members are more likely to consume alcohol frequently. Large reductions in estimates upon controlling for time spent partying, and to a lesser extent cigarette use and intramural sports involvement, suggest considerable unobserved heterogeneity in the relationship. Yet, effects remain substantive and are invariant to conditioning on numerous further measures of socializing, sports participation, academic performance and mental health. The conclusion holds when non-member comparison groups are restricted to drinkers who smoke, party and/or play intramurals, or matched to members based on drinking propensities, suggesting that fraternity/sorority membership raises alcohol use frequency.

Sadness, Suicidality and Grades

This study examines the past year relationship between GPA and experiencing a combination of two primary depression symptoms, feeling sad and losing interest in usual activities for at least two consecutive weeks, among high school students during 2001–2009. The GPA loss associated with sadness, as defined above, falls from slightly less than a plus/minus mark to around 0.1 point when commonly co-occurring behaviors are held constant. Nonetheless, this effect is significantly larger than those of having considered or planned suicide and equivalent to having attempted suicide, which seemingly signify more severe depression. Moreover, sadness lowers the probability of earning A grades, and raises that of receiving grades of C or below, by over 15%. Coefficient sizes are similar when comparison groups are restricted to students engaging in correlated behaviors and in matching and instrumental variable models, suggesting that sadness causally reduces academic performance.

Has the European Union Achieved a Single Pharmaceutical Market?

This paper explores price differences in the European Union (EU) pharmaceutical market, the EU's fifth largest industry. With the aim of enhancing quality of life along with industry competitiveness and R&D capability, many EU directives have been adopted to achieve a single EU-wide pharmaceutical market. Using annual 1994–2003 data on prices of molecules that treat cardiovascular disease, we examine whether drug price dispersion has indeed decreased across five EU countries. Hedonic regressions show that over time, cross-country price differences between Germany and three of the four other EU sample countries, France, Italy and Spain, have declined, with relative prices in all three as well as the fourth country, UK, rising during the period. We interpret this as evidence that the EU has come closer to achieving a single pharmaceutical market in response to increasing European Commission coordination efforts.

Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: Insight into functional group effects and biological activity

The synthesis and biological analysis of a number of novel congeners of the aminocyclopentitol pactamycin is described. Specific attention was paid to the preparation of derivatives at crucial synthetic branch points of the parent structure, and biological assays revealed a number of insights into the source of pactamycin’s biological activity. Additionally, the encapsulation of pactamycin and select derivatives into the PRINT© nanoparticle technology was investigated as a proof-of-concept, and evidence of bioactivity modulation through nanoparticle delivery is demonstrated. This work has provided heretofore unrealized access to a large number of novel compounds for further evaluation

Event-Related Potentials Dissociate Effects of Salience and Space in Biased Competition for Visual Representation

BACKGROUND: Selective visual attention is the process by which the visual system enhances behaviorally relevant stimuli and filters out others. Visual attention is thought to operate through a cortical mechanism known as biased competition. Representations of stimuli within cortical visual areas compete such that they mutually suppress each others' neural response. Competition increases with stimulus proximity and can be biased in favor of one stimulus (over another) as a function of stimulus significance, salience, or expectancy. Though there is considerable evidence of biased competition within the human visual system, the dynamics of the process remain unknown. METHODOLOGY/PRINCIPAL FINDINGS: Here, we used scalp-recorded electroencephalography (EEG) to examine neural correlates of biased competition in the human visual system. In two experiments, subjects performed a task requiring them to either simultaneously identify two targets (Experiment 1) or discriminate one target while ignoring a decoy (Experiment 2). Competition was manipulated by altering the spatial separation between target(s) and/or decoy. Both experimental tasks should induce competition between stimuli. However, only the task of Experiment 2 should invoke a strong bias in favor of the target (over the decoy). The amplitude of two lateralized components of the event-related potential, the N2pc and Ptc, mirrored these predictions. N2pc amplitude increased with increasing stimulus separation in Experiments 1 and 2. However, Ptc amplitude varied only in Experiment 2, becoming more positive with decreased spatial separation. CONCLUSIONS/SIGNIFICANCE: These results suggest that N2pc and Ptc components may index distinct processes of biased competition--N2pc reflecting visual competitive interactions and Ptc reflecting a bias in processing necessary to individuate task-relevant stimuli