Early Term Effects of rhBMP-2 on Pedicle Screw Fixation in a Sheep Model: Histomorphometric and Biomechanical Analyses

Background: The effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pedicle screw pullout force and its potential to improve spinal fixation have not previously been investigated. rhBMP-2 on an absorbable collagen sponge (ACS) carrier was delivered in and around cannulated and fenestrated pedicle screws in a sheep lumbar spine instability model. Two control groups (empty screw and ACS with buffer) were also evaluated. We hypothesized that rhBMP-2 could stimulate bone growth in and around the cannulated and fenestrated pedicle screws to improve early bone purchase. Methods: Eight skeletally mature sheep underwent destabilizing laminectomies at L2–L3 and L4–L5 followed by stabilization with pedicle screw and rod constructs. An ACS carrier was used to deliver 0.15 mg of rhBMP-2 within and around the cannulated and fenestrated titanium pedicle screws. Biomechanics and histomorphometry were used to evaluate the early term results at 6 and 12 postoperative weeks. Results: rhBMP-2 was unable to improve bony purchase of the cannulated and fenestrated pedicle screws compared to both control groups. Although rhBMP-2 groups had pullout forces that were less than both control groups, both rhBMP-2 groups had pullout force values exceeding 2,000 N, which was comparable to previously published results for unmodified pedicle screws. Significant differences in the percentages of bone in peri-screw tissues was not observed amongst the four treatment groups. Microradiography and quantitative histomorphometry showed that at 6 weeks, rhBMP-2 induced peri-screw remodeling regions containing peri-implant bone which was hypodense with respect to surrounding native trabeculae. A moderate correlation between biomechanical pullout variables and histomorphometry data was observed. Conclusions: The design of the cannulated and fenestrated pedicle screw was able to facilitate new bone formation to achieve high pullout forces. However, delivery of rhBMP-2 should be carefully controlled to prevent excessive bone remodeling which could cause early screw loosening

Polyetheretherketone as a Biomaterial for Spinal Applications

Threaded lumbar interbody spinal fusion devices (TIBFD) made from titanium have been reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been intensely debated in the literature. Using blinded radiographic, biomechanic, histologic, and statistical measures, we evaluated a radiolucent polyetheretherketone (PEEK)-threaded interbody fusion device packed with autograft or rhBMP-2 on an absorbable collagen sponge in 13 sheep at 6 months. Radiographic fusion, increased spinal level biomechanical stiffness, and histologic fusion were demonstrated for the PEEK cages filled with autograft or rhBMP-2 on a collagen sponge. No device degradation or wear debris was observed. Only mild chronic inflammation consisting of a few macrophages was observed in peri-implant tissues. Based on these results, the polymeric biomaterial PEEK may be a useful biomaterial for interbody fusion cages due to the polymer\u27s increased radiolucency and decreased stiffness

Characterization of low-noise quasi-optical SIS mixers for the submillimeter band

We report on the development of low-noise quasi-optical SIS mixers for the frequency range 400-850 GHz. The mixers utilize twin-slot antennas, two-junction tuning circuits, and Nb-trilayer junctions. Fourier-transform spectrometry has been used to verify that the frequency response of the devices is well predicted by computer simulations. The 400-850 GHz frequency band can be covered with four separate fixed-tuned mixers. We measure uncorrected double-sideband receiver noise temperatures around 5hν/kB to 700 GHz, and better than 540 K at 808 GHz. These results are among the best reported to date for broadband heterodyne receivers

Experimental and Numerical Analysis of Structural Acousticcontrol Interior Noise Reduction

The research results contained in this technical report were performed under the NASA grant entitled "Experimental and Numerical Structural Acoustic Control for Interior Noise Reduction". The report is based essentially on partial progress of the Ph.D. dissertation prepared by Jeffrey S. Bevan under direct guidance of Dr. Chuh Mei. The document presents a finite element formulation and control of sound radiated from cylindrical panels embedded with piezoceramic actuators. The extended MIN6 shallow shell element is fully electrical-structural coupled. A piezoelectric modal actuator participation (PMAP) is defined which indicates the actuator performance to each of the offending modes. Genetic algorithm is also employed to validate the sensor and actuator locations determined by the PMAP criteria. The work was conducted at the Department of Aerospace Engineering, Old Dominion University. Mr. Travis L. Turner, Structural Acoustics Branch, NASA Langley Research Center is the technical monitor

A constitutive equation for graphene based on density functional theory

AbstractAn anisotropic strain energy function is proposed for tensile loading in graphene that provides a nonlinear, hyperelastic constitutive equation. In the proposed function, the energy depends on the principal invariants of the right Cauchy–Green tensor and the strains in the zigzag and armchair directions. The use of the zigzag and armchair strains gives the model the ability to account for anisotropic behavior at moderate deformations. The constitutive law parameters are determined by a least squares fit to the energies predicted by density functional theory (DFT) calculations, and a good match is obtained to the DFT results for zigzag and armchair graphene sheets with various loading combinations. The law is applied in a continuum calculation of nanoindentation of a graphene membrane. The force–deflection predicted with this model show excellent agreement with analogous experimental results, thus providing a strong link between DFT calculations and nanoexperiments

Morphological approaches to understanding Antarctic Sea ice thickness

Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Oceanographic Engineering at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution September 2020.Sea ice thickness has long been an under-measured quantity, even in the satellite era. The snow surface elevation, which is far easier to measure, cannot be directly converted into sea ice thickness estimates without knowledge or assumption of what proportion of the snow surface consists of snow and ice. We do not fully understand how snow is distributed upon sea ice, in particular around areas with surface deformation. Here, we show that deep learning methods can be used to directly predict snow depth, as well as sea ice thickness, from measurements of surface topography obtained from laser altimetry. We also show that snow surfaces can be texturally distinguished, and that texturally-similar segments have similar snow depths. This can be used to predict snow depth at both local (sub-kilometer) and satellite (25 km) scales with much lower error and bias, and with greater ability to distinguish inter-annual and regional variability than current methods using linear regressions. We find that sea ice thickness can be estimated to ∼20% error at the kilometer scale. The success of deep learning methods to predict snow depth and sea ice thickness suggests that such methods may be also applied to temporally/spatially larger datasets like ICESat-2.This research was funded by National Aeronautics and Space Administration grant numbers NNX15AC69G and 80NSSC20K0972, the US National Science Foundation grant numbers ANT-1341513, ANT-1341606, ANT-1142075 and ANT-1341717, and the WHOI Academic Programs Office

A Molecular-Rotor Device for Nonvolatile High-Density Memory Applications

A novel memory device based on an electrically driven molecular rotor was fabricated and demonstrated to have bistable switching effects. The device showed an on/off ratio of approximately 10^4, a read window of about 2.5 V, and retention performance of greater than 10^4 s. The analysis of the device I–V characteristics suggests the source of the observed switching effects to be the redox-induced ligand rotation around the copper metal center, which is consistent with the observed temperature dependence of the switching behavior. This organic monolayer device holds a potential for nonvolatile high-density memory applications due to its scalability and reduced cost

Calving localization at Helheim Glacier using multiple local seismic stations

© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in The Cryosphere 11 (2017): 609-618, doi:10.5194/tc-11-609-2017.A multiple-station technique for localizing glacier calving events is applied to Helheim Glacier in southeastern Greenland. The difference in seismic-wave arrival times between each pairing of four local seismometers is used to generate a locus of possible event origins in the shape of a hyperbola. The intersection of the hyperbolas provides an estimate of the calving location. This method is used as the P and S waves are not distinguishable due to the proximity of the local seismometers to the event and the emergent nature of calving signals. We find that the seismic waves that arrive at the seismometers are dominated by surface (Rayleigh) waves. The surface-wave velocity for Helheim Glacier is estimated using a grid search with 11 calving events identified at Helheim from August 2014 to August 2015. From this, a catalogue of 11 calving locations is generated, showing that calving preferentially happens at the northern end of Helheim Glacier.The authors acknowledge the support of the Arctic Division of the Office of Polar Programs under grants ARC-0806393 and ARC-1304137

Room temperature negative differential resistance of a monolayer molecular rotor device

An electrically driven molecular rotor device comprised of a monolayer of redox-active ligated copper compounds sandwiched between a gold electrode and a highly doped P+Si substrate was fabricated. Current-voltage spectroscopy revealed a temperature-dependent negative differential resistance (NDR) associated with the device. Time-dependent density functional theory suggests the source of the observed NDR to be redox-induced ligand rotation around the copper metal center, an explanation consistent with the proposed energy diagram of the device. An observed temperature dependence of the NDR behavior further supports this hypothesis