Popular support for media freedom in Africa is a complicated picture

Africans’ support for press freedom had been on the decline for a decade. In the wake of new attacks on free speech and media across the continent, the latest evidence suggests that citizens might be pushing back against their governments’ oppressive measures

Structural priming and second language learning

This thesis investigates L2 structural priming in learners of English and the possible role of structural priming in second language acquisition. Three picture description production priming experiments were carried out in which speakers were exposed to prime sentences exhibiting a specific target structure. A pre- and post-test design was deployed to measure learning effects. In Experiment 1, fifty two L2 English speakers took part in a structural priming experiment targeting the production of get passives (e.g., the woman got arrested). Priming and learning effects were weak and were manifested in production of non-get passives. In contrast, in Experiment 2, where thirty eight L2 English speakers took part in another structural priming experiment targeting the production of stranded prepositions in relative clauses (e.g., a bed is something you sleep on), priming and learning effects were strong. The findings of learning through structural priming are interpreted as evidence of implicit learning of L2 structure. However, when the stranded preposition structure was primed in a different sentential context (i.e., the bed was too uncomfortable to sleep on) in a third experiment (n=40) only a weak priming effect emerged and there appeared to be no significant learning effect. These disparate findings suggest that the strength of L2 structural priming and subsequent learning effects might be modulated by the target structure. Implications for second language teaching and learning and theories of second language acquisition are discussed

A Candidate Brightest Proto-Cluster Galaxy at z = 3.03

We report the discovery of a very bright (m_R = 22.2) Lyman break galaxy at z = 3.03 that appears to be a massive system in a late stage of merging. Deep imaging reveals multiple peaks in the brightness profile with angular separations of ~0.''8 (~25 h^-1 kpc comoving). In addition, high signal-to-noise ratio rest-frame UV spectroscopy shows evidence for ~5 components based on stellar photospheric and ISM absorption lines with a velocity dispersion of sigma ~460 km s^-1 for the three strongest components. Both the dynamics and high luminosity, as well as our analysis of a LCDM numerical simulation, suggest a very massive system with halo mass M ~ 10^13 M_solar. The simulation finds that all halos at z = 3 of this mass contain sub-halos in agreement with the properties of these observed components and that such systems typically evolve into M ~ 10^14 M_solar halos in groups and clusters by z = 0. This discovery provides a rare opportunity to study the properties and individual components of z ~ 3 systems that are likely to be the progenitors to brightest cluster galaxies.Comment: 14 pages, 3 figures, submitted to ApJ Letter

Close Galaxy Pairs at z = 3: A Challenge to UV Luminosity Abundance Matching

We use a sample of z~3 Lyman Break Galaxies (LBGs) to examine close pair clustering statistics in comparison to LCDM-based models of structure formation. Samples are selected by matching the LBG number density and by matching the observed LBG 3-D correlation function of LBGs over the two-halo term region. We show that UV-luminosity abundance matching cannot reproduce the observed data, but if subhalos are chosen to reproduce the observed clustering of LBGs we are able to reproduce the observed LBG pair fraction, (Nc), defined as the average number of companions per galaxy. This model suggests an over abundance of LBGs by a factor of ~5 over those observed, suggesting that only 1 in 5 halos above a fixed mass hosts a galaxy with LBG-like UV luminosity detectable via LBG selection techniques. We find a total observable close pair fraction of 23 \pm 0.6% (17.7 \pm 0.5%) using a prototypical cylinder radius in our overdense fiducial model and 8.3 \pm 0.5% (5.6 \pm 0.2%) in an abundance matched model (impurity corrected). For the matched spectroscopic slit analysis, we find Ncs = 5.1\pm0.2% (1.68\pm0.02%), the average number of companions observed serendipitously in our for fiducial slits (abundance matched), whereas the observed fraction of serendipitous spectroscopic close pairs is 4.7\pm1.5 per cent using the full LBG sample and 7.1\pm2.3% for a subsample with higher signal-to-noise ratio. We show that the standard method of halo assignment fails to reproduce the break in the LBG close pair behavior at small scale. To reconcile these discrepancies we suggest that a plausible fraction of LBGs in close pairs with lower mass than our sample experience interaction-induced enhanced star formation that boosts their luminosity sufficiently to be detected in observational sample but are not included in the abundance matched simulation sample.Comment: 18 pages, 12 figures, 1 table, published in MNRA

Clinical setting influences off-label and unlicensed prescribing in a paediatric teaching hospital

Purpose - To estimate the prevalence of off-label and unlicensed prescribing during 2008 at a major paediatric teaching hospital in Western Australia. Methods - A 12-month retrospective study was conducted at Princess Margaret Hospital using medication chart records randomly selected from 145,550 patient encounters from the Emergency Department, Inpatient Wards and Outpatient Clinics. Patient and prescribing data were collected. Drugs were classified as off-label or unlicensed based on Australian registration data. A hierarchical system of age, indication, route of administration and dosage was used. Drugs were classified according to the Anatomical Therapeutic Chemical Code. Results - A total of 1,037 paediatric patients were selected where 2,654 prescriptions for 330 different drugs were prescribed to 699 patients (67.4%). Most off-label drugs (n = 295; 43.3%) were from the nervous system; a majority of unlicensed drugs were systemic hormonal preparations excluding sex hormones (n = 22, 32.4%). Inpatients were prescribed more off-label drugs than outpatients or Emergency Department patients (p < 0.0001). Most off-label prescribing occurred in infants and children (31.7% and 35.9% respectively) and the highest percentage of unlicensed prescribing (7.2%) occurred in infants (p < 0.0001). There were 25.7% of off-label and 2.6% of unlicensed medications prescribed across all three settings. Common reasons for off-label prescribing were dosage (47.4%) and age (43.2%). Conclusion - This study confirmed off-label and unlicensed use of drugs remains common. Further, that prevalence of both is influenced by the clinical setting, which has implications in regards to medication misadventure, and the need to have systems in place to minimise medication errors. Further, there remains a need for changes in the regulatory system in Australia to ensure that manufacturers incorporate, as it becomes available, evidence regarding efficacy and safety of their drugs in children in the official product information

Kepler eclipsing binary stars. VII. the catalogue of eclipsing binaries found in the entire Kepler data set

The primary Kepler Mission provided nearly continuous monitoring of ~200,000 objects with unprecedented photometric precision. We present the final catalog of eclipsing binary systems within the 105 deg2 Kepler field of view. This release incorporates the full extent of the data from the primary mission (Q0-Q17 Data Release). As a result, new systems have been added, additional false positives have been removed, ephemerides and principal parameters have been recomputed, classifications have been revised to rely on analytical models, and eclipse timing variations have been computed for each system. We identify several classes of systems including those that exhibit tertiary eclipse events, systems that show clear evidence of additional bodies, heartbeat systems, systems with changing eclipse depths, and systems exhibiting only one eclipse event over the duration of the mission. We have updated the period and galactic latitude distribution diagrams and included a catalog completeness evaluation. The total number of identified eclipsing and ellipsoidal binary systems in the Kepler field of view has increased to 2878, 1.3% of all observed Kepler targets

Individual common variants exert weak effects on the risk for autism spectrum disorders.

While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm&lt; 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest