9 research outputs found
Epigenetic silencing of DSC3 is a common event in human breast cancer
- Author
- A Dobrovic
- Anne E Cress
- Bernard W Futscher
- BW Futscher
- C Beroud
- C Tselepis
- Christina J Kim
- D Hanahan
- Damian J Junk
- DR Garrod
- DS Millar
- DS Millar
- FE Domann
- FF Costa
- Frederick E Domann
- GK Johnson
- GT Klus
- J Arnemann
- J Tost
- J Zabner
- JC Rice
- JC Rice
- JC Rice
- JE Collins
- Jeanne A Burr
- José L Muñoz-Rodríguez
- JR Graff
- JR Graff
- KE Bachman
- M Esteller
- M Kondo
- M Widschwendter
- MA Chidgey
- Marc M Oshiro
- Matthew Fitzgerald
- MD Sternlicht
- MJ Wheelock
- MM Oshiro
- P Boukamp
- PA Jones
- PJ Koch
- PJ Kowalski
- PL Gadhavi
- R Dammann
- Ryan J Wozniak
- S Getsios
- Sangita C Pawar
- SB Baylin
- SK Runswick
- SM Troyanovsky
- T Bianco
- UA Nuber
- Y Hanakawa
- Y Huang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
INTRODUCTION: Desmocollin 3 (DSC3) is a member of the cadherin superfamily of calcium-dependent cell adhesion molecules and a principle component of desmosomes. Desmosomal proteins such as DSC3 are integral to the maintenance of tissue architecture and the loss of these components leads to a lack of adhesion and a gain of cellular mobility. DSC3 expression is down-regulated in breast cancer cell lines and primary breast tumors; however, the loss of DSC3 is not due to gene deletion or gross rearrangement of the gene. In this study, we examined the prevalence of epigenetic silencing of DSC3 gene expression in primary breast tumor specimens. METHODS: We used bisulfite genomic sequencing to analyze the methylation state of the DSC3 promoter region from 32 primary breast tumor specimens. We also used a quantitative real-time RT-PCR approach, and analyzed all breast tumor specimens for DSC3 expression. Finally, in addition to bisulfite sequencing and RT-PCR, we used an in vivo nuclease accessibility assay to determine the chromatin architecture of the CpG island region from DSC3-negative breast cancer cells lines. RESULTS: DSC3 expression was downregulated in 23 of 32 (72%) breast cancer specimens comprising: 22 invasive ductal carcinomas, 7 invasive lobular breast carcinomas, 2 invasive ductal carcinomas that metastasized to the lymph node, and a mucoid ductal carcinoma. Of the 23 specimens showing a loss of DSC3 expression, 13 (56%) were associated with cytosine hypermethylation of the promoter region. Furthermore, DSC3 expression is limited to cells of epithelial origin and its expression of mRNA and protein is lost in a high proportion of breast tumor cell lines (79%). Lastly, DNA hypermethylation of the DSC3 promoter is highly correlated with a closed chromatin structure. CONCLUSION: These results indicate that the loss of DSC3 expression is a common event in primary breast tumor specimens, and that DSC3 gene silencing in breast tumors is frequently linked to aberrant cytosine methylation and concomitant changes in chromatin structure
Oxidation of vitamin E during iron-catalyzed lipid peroxidation: evidence for electron-transfer reactions of the tocopheroxyl radical
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Reactions of the vitamin E model compound 2,2,5,7,8-pentamethylchroman-6-ol with peroxyl radicals
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Fiddling, Pointing, Hovering, and Sliding:Embodied Actions with Three Evaluation Tools for Children
- Author
- Airey Sharon
- Annette
- Bark Ida
- Berger Peter L.
- Brosterman Norman
- Burr Vivien
- Caillois Roger
- Charmaz Kathy
- Chisik Yoram I.
- Cloud John
- Edward
- Galbraith Michael W.
- Garger Stephen
- Geogios
- Heath Christian
- Higbee Jeanne L.
- Joffe Hélène
- Kirsh David
- Mason Malia F
- McGrenere Joanna
- Norman Donald A.
- Read Janet C.
- Resnick Mitchel
- Rubie-Davies Christine M.
- Salen Katie
- Schwandt Thomas A.
- Schön Donald A.
- Segura Elena Márquez
- Sheets-Johnstone Maxine
- Slater Donald
- Treadaway Cathy
- Vygotsky Lev S.
- Werner Heinz
- Wertsch James V.
- Wertsch James V.
- Wickens Christopher D.
- Wilson Frank R
- Wu Li-Yuan
- Publication venue
- 'Association for Computing Machinery (ACM)'
- Publication date
- 01/10/2019
- Field of study
Why mâle
- Author
- Alessio Giovanni.
- Allen W. Sidney.
- Alvar Manuel
- Bloch Oscar
- Bourciez Edouard
- Burr Isolde.
- Charles Guerlin de Guer
- Cotgrave Randle.
- Daniel Recasens i Vives
- Dauby Jean.
- Dauzat Albert.
- de la Chaussée François.
- de la Chaussée François.
- DEAF
- Diez Friedrich.
- Elcock William D.
- Ernout Alfred
- Flutre Louis-Fernand.
- Fouché Pierre.
- Fouché Pierre.
- Frere Sheppard.
- Gaston Zink
- Gilliéron Jules
- Goetz Georg
- Guinet Louis.
- Hall Robert A.
- Hatzfeld Helmut
- Hualde José Ignacio.
- James Edward.
- Le Blant Edmond F.
- Loporcaro Michele.
- Lutta C. Martin.
- Molho Mauricio.
- Morin Yves Charles.
- Morlet Marie-Thérèse.
- Nyrop Kristoffer.
- Oudin Antoine.
- Palsgrave John.
- Peer Oscar.
- Prou Maurice.
- Regula Moritz.
- Repetti Lori
- Rey Alain
- Rheinfelder Hans.
- Rohlfs Gerhard.
- Sampson Rodney.
- Sampson Rodney.
- Scheer Tobias
- Schwan Eduard
- Simoni-Aurembou Marie-Rose.
- Steriade Donca.
- Theo Vennemann
- Thurot Charles.
- Timpanaro Sebastiano.
- Tomás Navarro Tomás
- Trévoux
- Vielliard Jeanne.
- Väänänen Veikko.
- Walther von Wartburg
- wilhelm meyer-lübke
- Witold Man´czak
- Wüest Jakob.
- Publication venue
- 'Brepols Publishers NV'
- Publication date
- Field of study
Polarity in plants
- Author
- A. B. Brown
- A. C. Joshi
- A. Hagemann
- A. M. Showalter
- A. M. Wolfson
- A. N. J. Heyn
- A. S. Merjanian
- A. Th. Czaja
- A. Th. Czaja
- A. Th. Czaja
- A. Th. Czaja
- A. Trécul
- A. Ursprung
- Anita Kaan Albest von
- Annie May Hurd
- Annie May Hurd
- Annie May Hurd-Karrer
- B. Němec
- B. Němec
- C. LaMotte
- C. M. Child
- Carola Ossenbeck
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. M. Whitaker
- D. Mäule
- E. A. Reed
- E. Bergdolt
- E. Bünning
- E. J. Lund
- E. J. Lund
- E. J. Lund
- E. J. Lund
- E. J. Lund
- E. Knapp
- E. Küster
- E. Küster
- E. Stahl
- E. W. Lowrance
- E. W. Lowrance
- E. W. Lowrance
- E. W. Sinnott
- E. W. Sinnott
- E. W. Sinnott
- E. W. Sinnott
- E. Wulff
- F. G. Brieger
- F. Laibach
- F. Neeff
- F. Neeff
- F. Noll
- F. Noll
- F. Schwanitz
- F. Skoog
- F. Steinecke
- F. Tobler
- F. Tobler
- F. W. Went
- F. W. Went
- F. W. Went
- F. W. Went
- F. W. Went
- F. Weber
- Francis O. Schmitt
- G. A. Borowikow
- G. B. Wolcott
- G. Berthold
- G. Hellinga
- G. J. Allman
- G. Klebs
- G. Marsh
- G. Mosebach
- G. S. Avery
- G. S. Avery
- H. A. A. Lek van der
- H. Crüger
- H. D. Wulff
- H. Dickson
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- H. F. Rosene
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- H. Fitting
- H. Fitting
- H. Fitting
- H. Fitting
- H. G. Albaum
- H. G. Albaum
- H. G. Buy Du
- H. G. Buy Du
- H. G. Buy Du
- H. Kniep
- H. Kylin
- H. Leitgeb
- H. Leitgeb
- H. Leitgeb
- H. Lundegardh
- H. Lundegardh
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- H. Miehe
- H. S. Burr
- H. Timmel
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- H. Vöchting
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- H. Winkler
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- J. Hämmerling
- J. Hämmerling
- J. Hämmerling
- J. Hämmerling
- J. Hämmerling
- J. Hämmerling
- J. Lefèvre
- J. Lefèvre
- J. M. Diehl
- J. M. Janse
- J. M. Janse
- J. M. Janse
- J. M. Janse
- J. M. Janse
- J. M. Janse
- J. Massart
- J. Rappaport
- J. Sachs
- J. W. Pont
- J. Weir
- J. Westerdijk
- Jeanne Terby
- K. Arens
- K. B. Raper
- K. B. Raper
- K. Behre
- K. Bussmann
- K. Bussmann
- K. Goebel
- K. Goebel
- K. Goebel
- K. Goebel
- K. Goebel
- K. Lohwag
- K. Prantl
- K. Ramschorn
- K. Ramshorn
- Karl Sax
- Karl Sax
- Karl Silberschmidt
- L. Dippel
- L. Geitler
- L. H. MacDaniels
- L. K. Rosenvinge
- L. Kny
- L. R. Blinks
- M. Abeloos
- M. P. Both
- N. G. Cholodny
- N. G. Cholodny
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- N. G. Cholodny
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- O. Fischnich
- O. Fischnich
- P. Jaccard
- P. Maheshwari
- P. Prevot
- P. W. Zimmerman
- Phyllis A. Hicks
- R. A. Olson
- R. Beyerle
- R. Bloch
- R. Bloch
- R. C. Lindner
- R. C. Lindner
- R. Castan
- R. Castan
- R. D. Preston
- R. D. Preston
- R. D. Preston
- R. Dostál
- R. Dostál
- R. Dostál
- R. Dostál
- R. G. Harrison
- R. G. Harrison
- R. H. Stoughton
- R. H. Thompson
- R. J. D. Graham
- R. Veh von
- Robert Bloch
- Rose M. Tupper-Carey
- S. A. E. Gratzy-Wardengg
- S. Kinoshita
- S. Kinoshita
- S. Rostowzew
- S. V. Simon
- S. V. Simon
- S. V. Simon
- T. H. Morgan
- T. H. Morgan
- T. H. Morgan
- T. H. Morgan
- T. T. Colquhoun
- V. Schechter
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- W. A. Sledge
- W. B. McCallum
- W. B. Shippy
- W. G. Clark
- W. G. Clark
- W. Kreh
- W. Magnus
- W. Neilson Jones
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- W. Nienburg
- W. S. Rehm
- W. S. Rehm
- W. Schumacher
- W. Schumacher
- W. Schwartz
- W. Seifriz
- W. Zimmermann
- W. Zimmermann
- W. Zimmermann
- W. Zimmermann
- W. Zimmermann
- Wm Plant
- Wm Plant
- Y. Freund
- É. Wildemann de
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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Special Reviewers
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- Abma Joyce
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- Shackelford Todd K.
- Shah Anisha
- Shanahan Lilly
- Shapiro Adam
- Sharp Elizabeth A.
- Shebloski Barbara
- Sherkat Darren
- Shibley Hyde Janet
- Short Susan
- Shorter-Gooden Kumea
- Shuey Kim
- Shumow Lee
- Sigle-Rushton Wendy
- Silverstein Louise
- Silverstein Merril
- Simons Leslie
- Singla Rashmi
- Smith David
- Smith Suzanne R.
- Smock Pamela J.
- Smulyan Lisa
- Snider Blake
- Snyder Karrie
- Sobolewski Juliana
- Somers Cheryl
- South Scott J.
- Spearin Carrie E.
- Springer Kristin W.
- Staik Athena
- Stanley Scott
- Sterk Claire
- Stern Phyllis
- Stevens Greenberg Jan
- Stevens Daphne
- Stevenson Michelle L.
- Stewart Robert
- Stewart Susan D.
- Stiles Beverly
- Stockard Jean
- Strassmann Beverly
- Strohschein Lisa
- Stum Marlene
- Suitor J. Jill
- Sun Yongmin
- Supple Andrew
- Surra Catherine A.
- Swanberg Jennifer E.
- Sweeney Kathryn
- Sweeney Megan M.
- Sweet Stephen
- Swinford Steven
- Takigiku Susan K.
- Tanfer Koray
- Tayki Baffour K.
- Taylor Tiffany
- Teerawichitchainan Bussarawan P.
- Tein Jenn-Yun
- Temple Jeff
- Thompson Gershoff Elizabeth
- Thomson Elizabeth
- Tiefenthaler Jill
- Tomassini Cecilia
- Torr Berna S.
- Trent Katherine
- Trzcinski Ellen
- Tschann Jeanne M.
- Uhlenberg Peter
- Umana-Taylor Adriana
- Umberson Debra J.
- Updegraff Kimberly
- Usdansky Margaret
- Uttal Lynet
- Van Gaalen Ruben I.
- Vogt Yuan Anastasia
- Vollebergh Wilma
- Volling Brenda
- Voorpostel Marieke
- Votruba-Drzal Elizabeth
- Voydanoff Patricia
- Waite Linda J.
- Waldfogel Jane
- Warner Barbara
- Warren Tracey
- Weeden Kim A.
- Weiting Steve
- Wenger G. Clare
- West Jerry
- Wethington Elaine
- Whitchurch Gail G.
- White James M.
- White-Stephan Cookie
- Whiteman Shawn
- Widmer Eric D.
- Wieting Stephen
- Wilcox W. Bradford
- Wildsmith Elizabeth
- Williams Kristi
- Wills Jeremiah
- Willson Andrea
- Wilmoth Janet
- Wilson John
- Winkler Celia C.
- Winslow Sarah
- Wojtkiewicz Roger A.
- Wolfinger Nicholas H.
- Wright Eric R.
- Yabiku Scott T.
- Yagla Mack Kristin
- Yancey George A.
- Yang Frances
- Yeh Hsin-Chen
- Yeung Wei-Jun Jean
- Yount Kathryn
- Zabin Laurie
- Zhang Zhenmei
- Zuo Jiping
- Zweig Janine
- Publication venue
- Publication date
- 01/12/2005
- Field of study
PRESERVATION DISASTER PLANNING
- Author
- Accurti Dante
- Adamonis Beverly Ann
- Alexander David
- Ambrosino Leslie
- Amoroso Louis J.
- Anderson Hazel
- Astle D. L.
- Baas Valerie
- Baker Richard C.
- Barton John P.
- Behrendt Elizabeth C.
- Belaya I. K.
- Benedon William
- Boccaccio Mary
- Bohem Hilda
- Bohem Hilda
- Bologna Jack
- Bower Peter
- Boyle D.
- Brewer Norval L.
- Bryan John L.
- Buchanan Sally
- Buchanan Sally
- Buchanan Sally
- Buchanan Sally
- Burns Robert
- Burr Nelson R.
- Byers Barry
- Casey Mary Lou
- Chamberlain William R.
- Chapman Joseph
- Clarke O. A.
- Cohen W. M.
- Collier Virginia
- Cotton P. E.
- Craven Jim
- Culver Charles G.
- Cunha George M.
- Cunha George M.
- Cunha George M.
- Cunha George M.
- Cunha George M.
- Curless M.
- Day Karen
- Decandido Robert
- Deken Jean Marie
- Dempsey D.
- Donaldson Richard C.
- Douglas McDonnell
- Dowling J. H.
- Draper Frank
- Dubose Beverly M.
- Dukett Kenneth W.
- Dykins Jeanne
- Eagleman J. R.
- Entwisle Rosemary
- Eulenberg Julia Niebuhr
- Fennelly Lawrence
- Fischer David J.
- Fisher Walter R.
- Fitzsimmons Neal
- Flink James
- Fortson-Jones
- Fortson-Jones
- Fortson-Jones Judith
- Fuss Eugene
- Gandert Slade Richard
- Garb Soloman
- Gellie Beverly
- Gelman Woody
- Gervasio Louis2
- Gest Bruce
- Gibson J. A.
- Goetz A. H.
- Greenfeld Howard
- Griffith J. W.
- Hamlin A. T.
- Hansen A. T.
- Harvey Bruce K.
- Harvey Bruce K.
- Has J. Eugene
- Healy Richard J.
- Heiges M. J.
- Hemphill B. F.
- Hendriks Klaus B.
- Hill Thomas T.
- Hoffman F. W.
- Horton Carolyn
- Horton Carolyn
- Horton Carolyn
- Houghton E. L.
- Houk Judy
- Hunter John E.
- Hunter John E.
- Jedeed Nidal
- Jordon M.
- Jordon René
- Kathpalia Yash Pal
- Keck Caroline
- Keck Sheldon
- Keeler David Z.
- Kelley John
- Kelly Michael
- Kennedy J.
- Kenneweg Richard
- King Richard G.
- Kintner Anne G.
- Klein Henry
- Koesterer Martin G.
- Koesterer Martin G.
- Kula Sam
- Langelier
- Leighton Phillip D.
- London Sol
- Long Margery S.
- Lowell Howard P.
- Lowell Howard P.
- Lynskey Thomas A.
- Marshall Richard D.
- Martin John H.
- Martin John H.
- Mathieson David F.
- Matthai Robert A.
- Maylone R. Russell
- McColgin Michael
- McCrady Ellén
- McCue Gerald M.
- McGregor L.
- McGuril M. C.
- Minogue Adelaide E.
- Montuori Theodore R.
- Montuori Theodore R.
- Moon Myra Jo
- Morris John
- Morris John
- Morris John
- Morris John
- Morrison Robert C.
- Morrow Carolyn Clark
- Morrow Carolyn Clark
- Murray Toby
- Myers Gerald E.
- Myers James N.
- Nelson C. W.
- Nelson C. W.
- Nelson C. W.
- Nelson Dale
- Nelson William G.
- Nolan Pat
- Organ Robert M.
- Pasek Frank
- Patterson Robert H.
- Patterson Robert H.
- Probst Tom
- Reams Bernard D.
- Reed Vilia L.
- Regan Ed
- Richardson G. D.
- Roth Harold L.
- Ruggere
- Sable Martin H.
- Samulski Peter
- Schell H. B.
- Schmelzer Menahem
- Schnell Mary L.
- Schnell Mary L.
- Schoonover Larry
- Schur Susan E.
- Schur Susan E.
- Seal Robert A.
- Seal Robert A.
- Sellers David Y.
- Spawn Willman
- Stanzler Margaret A.
- Stender Walter W.
- Stevens J. N.
- Still J. S.
- Streit Samuel
- Surrency Erwin C.
- Surrency Erwin C.
- Swartzburg Susan G.
- Swartzburg Susan G.
- Tiskus Alphonse T.
- Trelles O. M.
- Tribolet H. W.
- Tribolet H. W.
- Tribolet Harold W.
- Upton M. S.
- Voronona L. I.
- Walch Timothy
- Walston S.
- Waters Peter
- Waters Peter
- Watson Adele L.
- We Go Here
- Weidner Marilyn Kemp
- Weinstein Frances Ruth
- Weiss Harry B.
- Welker Franklin N.
- Whipkey Harry E.
- Whitson Helene
- Whittow John
- Willey A. Elwood
- Wright Gordon H.
- Wrotenbery Carl R.
- Yeats R. C.
- Yoho C. H.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study