African Global Health: an initiative committed to achieving Health Sovereignty in the Global South

The COVID-19 pandemic has played a crucial role in accelerating the shift in healthcare. Indeed, the pandemic has been an unprecedented global health crisis that has shaken the foundations of healthcare systems worldwide. It has exposed vulnerabilities in health systems, especially in Africa, and underscored the critical need for sovereign health systems to address the continent's unique challenges

Tackling the twin threats of pandemics and climate change: an agenda for action

Ending fossil fuel dependence is a prerequisite for a healthier world and future generations. The direct health impact of climate change driven by fossil fuel emissions is already devastating. The triple planetary pollution crisis, biodiversity loss, and climate change exacerbate the impact. The World Health Organization (WHO) predicts that between 2030 and 2050, climate change is expected to cause approximately 250,000 additional deaths per year

African leadership is critical in responding to public health threats

The African continent demonstrated decisive leadership throughout its response to the COVID-19 pandemic, leveraging lessons learned from previous outbreaks and acting quickly to limit the impact of the SARS-CoV-2 virus. We propose a framework to build on these successes that calls for greater collaboration between African leaders, and greater inclusion of African voices in the global health ecosystem

Time to establish an international vaccine candidate pool for potential highly infectious respiratory disease: a community’s view

Summary: In counteracting highly infectious and disruptive respiratory diseases such as COVID-19, vaccination remains the primary and safest way to prevent disease, reduce the severity of illness, and save lives. Unfortunately, vaccination is often not the first intervention deployed for a new pandemic, as it takes time to develop and test vaccines, and confirmation of safety requires a period of observation after vaccination to detect potential late-onset vaccine-associated adverse events. In the meantime, nonpharmacologic public health interventions such as mask-wearing and social distancing can provide some degree of protection. As climate change, with its environmental impacts on pathogen evolution and international mobility continue to rise, highly infectious respiratory diseases will likely emerge more frequently and their impact is expected to be substantial. How quickly a safe and efficacious vaccine can be deployed against rising infectious respiratory diseases may be the most important challenge that humanity will face in the near future. While some organizations are engaged in addressing the World Health Organization's ''blueprint for priority diseases'', the lack of worldwide preparedness, and the uncertainty around universal vaccine availability, remain major concerns. We therefore propose the establishment of an international candidate vaccine pool repository for potential respiratory diseases, supported by multiple stakeholders and countries that contribute facilities, technologies, and other medical and financial resources. The types and categories of candidate vaccines can be determined based on information from previous pandemics and epidemics. Each participant country or region can focus on developing one or a few vaccine types or categories, together covering most if not all possible potential infectious diseases. The safety of these vaccines can be tested using animal models. Information for effective candidates that can be potentially applied to humans will then be shared across all participants. When a new pandemic arises, these pre-selected and tested vaccines can be quickly tested in RCTs for human populations