Relationship between sleep and obesity among U.S. and South Korean college students

Background Little is known about the relationship between sleep and obesity in young adults, particularly college students. This study examined the relationship between sleep (i.e., sleep duration and quality) and obesity in a large and diverse binational sample of college students. Methods Analyses were based on a 40-item paper survey from 2016/2017 to 2017/2018 academic years, with a 72% response rate. The samples were 1578 college students aged 18–25 years from five universities (two in the U.S. and three in South Korea). Weight and height were measured objectively; other measures (e.g., health behaviors) were self-reported. Multinomial logistic regression was used to assess the association between sleep duration and independent variables (race/nationality, gender, and BMI). Poisson regression was used to examine the relationship between sleep quality and independent variables. Results Overall, blacks had a higher adjusted odds ratio (AOR) of short sleep (\u3c 7 h/night) than whites (AOR = 1.74, P \u3c .01); overweight participants had a higher AOR of short sleep than normal weight participants (AOR = 1.52, P \u3c .01); and obese participants had a higher AORs of both short and long sleep (\u3e 9 h/night) (AOR = 1.67, P \u3c .01; AOR = 1.79, P \u3c .05, respectively). Among men, being black, overweight, and obesity were associated with short sleep (P \u3c .05), whereas only obesity was related to short sleep among women (P \u3c .05). In analyses stratified by race and nationality, overweight and obesity were related to short sleep among blacks only (P \u3c .05). Overall, sleep quality (getting enough sleep to feel rested in the morning in the past 7 days) was worse in blacks and South Koreans than whites (P \u3c .05), worse in women than men (P \u3c .05), and worse in participants with obesity than normal weight participants (P \u3c .05). Conclusions Obesity was associated with both short (\u3c 7 h/night) and long sleep duration (\u3e 9 h/night) and poor sleep quality among all participants. In comparison with whites, blacks were more like to have short sleep, and blacks and South Koreans had worse sleep quality. Further investigations using a larger sample of college students in multiple countries may be helpful to identify target populations who are at a greater risk of obesity and sleep problems

Integral field spectroscopy of four lensed quasars: analysis of their neighborhood and evidence for microlensing

CONTEXT: Gravitationally lensed quasars constitute an independent tool to derive H0 through time-delays; they offer as well the opportunity to study the mass distribution and interstellar medium of their lensing galaxies and, through microlensing they also allow one to study details of the emitting source. AIMS: For such studies, one needs to have an excellent knowledge of the close environment of the lensed images in order to model the lensing potential: this means observational data over a large field-of-view and spectroscopy at high spatial resolution. METHODS: We present VIMOS integral field observations around four lensed quasars: HE 0230-2130, RX J0911.4+0551, H 1413+117 and B 1359+154. Using the low, medium and high resolution modes, we study the quasar images and the quasar environments, as well as provide a detailed report of the data reduction. RESULTS: Comparison between the quasar spectra of the different images reveals differences for HE 0230-2130, RX J0911.4+0551 and H 1413+117: flux ratios between the images of the same quasar are different when measured in the emission lines and in the continuum. We have also measured the redshifts of galaxies in the neighborhood of HE 0230-2130 and RX J0911.4+0551 which possibly contribute to the total lensing potential. CONCLUSIONS: A careful analysis reveals that microlensing is the most natural explanation for the (de)magnification of the continuum emitting region of the background sources. In HE 0230-2130, image D is likely to be affected by microlensing magnification; in RX J0911.4+0551, images A1 and A3 are likely to be modified by microlensing de-magnification and in H 1413+117, at least image D is affected by microlensing.Comment: 13 pages, 18 figures. Accepted for publication in A&A: January 7, 200

Structural Variants Drive Context-Dependent Oncogene Activation in Cancer

Higher-order chromatin structure is important for the regulation of genes by distal regulatory sequences. Structural variants (SVs) that alter three-dimensional (3D) genome organization can lead to enhancer-promoter rewiring and human disease, particularly in the context of cancer3. However, only a small minority of SVs are associated with altered gene expression4,5, and it remains unclear why certain SVs lead to changes in distal gene expression and others do not. To address these questions, we used a combination of genomic profiling and genome engineering to identify sites of recurrent changes in 3D genome structure in cancer and determine the effects of specific rearrangements on oncogene activation. By analysing Hi-C data from 92 cancer cell lines and patient samples, we identified loci affected by recurrent alterations to 3D genome structure, including oncogenes such as MYC, TERT and CCND1. By using CRISPR-Cas9 genome engineering to generate de novo SVs, we show that oncogene activity can be predicted by using \u27activity-by-contact\u27 models that consider partner region chromatin contacts and enhancer activity. However, activity-by-contact models are only predictive of specific subsets of genes in the genome, suggesting that different classes of genes engage in distinct modes of regulation by distal regulatory elements. These results indicate that SVs that alter 3D genome organization are widespread in cancer genomes and begin to illustrate predictive rules for the consequences of SVs on oncogene activation

Relationship between sleep and obesity among U.S. and South Korean college students

Background Little is known about the relationship between sleep and obesity in young adults, particularly college students. This study examined the relationship between sleep (i.e., sleep duration and quality) and obesity in a large and diverse binational sample of college students. Methods Analyses were based on a 40-item paper survey from 2016/2017 to 2017/2018 academic years, with a 72% response rate. The samples were 1578 college students aged 18–25 years from five universities (two in the U.S. and three in South Korea). Weight and height were measured objectively; other measures (e.g., health behaviors) were self-reported. Multinomial logistic regression was used to assess the association between sleep duration and independent variables (race/nationality, gender, and BMI). Poisson regression was used to examine the relationship between sleep quality and independent variables. Results Overall, blacks had a higher adjusted odds ratio (AOR) of short sleep ( 9 h/night) (AOR = 1.67, P < .01; AOR = 1.79, P < .05, respectively). Among men, being black, overweight, and obesity were associated with short sleep (P < .05), whereas only obesity was related to short sleep among women (P < .05). In analyses stratified by race and nationality, overweight and obesity were related to short sleep among blacks only (P < .05). Overall, sleep quality (getting enough sleep to feel rested in the morning in the past 7 days) was worse in blacks and South Koreans than whites (P < .05), worse in women than men (P < .05), and worse in participants with obesity than normal weight participants (P < .05). Conclusions Obesity was associated with both short ( 9 h/night) and poor sleep quality among all participants. In comparison with whites, blacks were more like to have short sleep, and blacks and South Koreans had worse sleep quality. Further investigations using a larger sample of college students in multiple countries may be helpful to identify target populations who are at a greater risk of obesity and sleep problems

A Study of Gravitational Lens Chromaticity with the Hubble Space Telescope

We report Hubble Space Telescope observations of 6 gravitational lenses with the Advanced Camera for Surveys. We measured the flux ratios between the lensed images in 6 filters from 8140\AA\ to 2200\AA. In 3 of the systems, HE0512$-$3329, B1600+434, and H1413+117, we were able to construct UV extinction curves partially overlapping the 2175\AA\ feature and characterize the properties of the dust relative to the Galaxy and the Magellanic Clouds. In HE1104$-$1804 we detect chromatic microlensing and use it to study the physical properties of the quasar accretion disk. For a Gaussian model of the disk $\exp(-r^2/2 r_s^2)$, scaling with wavelength as $r_s \propto \lambda^p$, we estimate $r_s(\lambda3363)=4^{+4}_{-2}$ ($7\pm 4$) light-days and $p=1.1\pm 0.6$ ($1.0\pm 0.6$) for a logarithmic (linear) prior on $r_s$. The remaining two systems, FBQ0951+2635 and SBS1520+530, yielded no useful estimates of extinction or chromatic microlensing.Comment: 31 pages, 12 figures, 4 tables, ApJ submitte

Sl-IAA3, a tomato Aux/IAA at the crossroads of auxin and ethylene signalling involved in differential growth

Whereas the interplay of multiple hormones is essential for most plant developmental processes, the key integrating molecular players remain largely undiscovered or uncharacterized. It is shown here that a member of the tomato auxin/indole-3-acetic acid (Aux/IAA) gene family, Sl-IAA3, intersects the auxin and ethylene signal transduction pathways. Aux/IAA genes encode short-lived transcriptional regulators central to the control of auxin responses. Their functions have been defined primarily by dominant, gain-of-function mutant alleles in Arabidopsis. The Sl-IAA3 gene encodes a nuclear-targeted protein that can repress transcription from auxin-responsive promoters. Sl-IAA3 expression is auxin and ethylene dependent, is regulated on a tight tissue-specific basis, and is associated with tissues undergoing differential growth such as in epinastic petioles and apical hook. Antisense down-regulation of Sl-IAA3 results in auxin and ethylene-related phenotypes, including altered apical dominance, lower auxin sensitivity, exaggerated apical hook curvature in the dark and reduced petiole epinasty in the light. The results provide novel insights into the roles of Aux/IAAs and position the Sl-IAA3 protein at the crossroads of auxin and ethylene signalling in tomato

Long Term Stabilization of Expanding Aortic Aneurysms by a Short Course of Cyclosporine A through Transforming Growth Factor-Beta Induction

Abdominal aortic aneurysms (AAAs) expand as a consequence of extracellular matrix destruction, and vascular smooth muscle cell (VSMC) depletion. Transforming growth factor (TGF)-beta 1 overexpression stabilizes expanding AAAs in rat. Cyclosporine A (CsA) promotes tissue accumulation and induces TGF -beta1 and, could thereby exert beneficial effects on AAA remodelling and expansion. In this study, we assessed whether a short administration of CsA could durably stabilize AAAs through TGF-beta induction. We showed that CsA induced TGF-beta1 and decreased MMP-9 expression dose-dependently in fragments of human AAAs in vitro, and in animal models of AAA in vivo. CsA prevented AAA formation at 14 days in the rat elastase (diameter increase: CsA: 131.9±44.2%; vehicle: 225.9±57.0%, P = 0.003) and calcium chloride mouse models (diameters: CsA: 0.72±0.14 mm; vehicle: 1.10±0.11 mm, P = .008), preserved elastic fiber network and VSMC content, and decreased inflammation. A seven day administration of CsA stabilized formed AAAs in rats seven weeks after drug withdrawal (diameter increase: CsA: 14.2±15.1%; vehicle: 45.2±13.7%, P = .017), down-regulated wall inflammation, and increased αSMA-positive cell content. Co-administration of a blocking anti-TGF-beta antibody abrogated CsA impact on inflammation, αSMA-positive cell accumulation and diameter control in expanding AAAs. Our study demonstrates that pharmacological induction of TGF-beta1 by a short course of CsA administration represents a new approach to induce aneurysm stabilization by shifting the degradation/repair balance towards healing