Broken Guidewire Fragment in the Radio-brachial Artery During Transradial Sheath Placement: Percutaneous Retrieval via Femoral Approach

A case in which a 0.014" wire was broken during the sheath placement in the radial artery for transradial coronary procedure is described here, and a successful retrieval of it using conventional methods is also described. Through the left femoral artery, the 6 Fr guiding catheter was advanced down to the tip of the broken wire at the brachial artery, and the distal part of the broken guidewire was captivated into the guiding catheter. By inflating the balloon catheter inside of the guiding catheter, seized broken guidewire between the inflated balloon and the guiding catheter was removed successfully by withdrawing the whole system en bloc

Role of non-thermal electrons in ultrafast spin dynamics of ferromagnetic multilayer

Understanding of ultrafast spin dynamics is crucial for future spintronic applications. In particular, the role of non-thermal electrons needs further investigation in order to gain a fundamental understanding of photoinduced demagnetization and remagnetization on a femtosecond time scale. We experimentally demonstrate that non-thermal electrons existing in the very early phase of the photoinduced demagnetization process play a key role in governing the overall ultrafast spin dynamics behavior. We simultaneously measured the time-resolved reflectivity (TR-R) and the magneto-optical Kerr effect (TR-MOKE) for a Co/Pt multilayer film. By using an extended three-temperature model (E3TM), the quantitative analysis, including non-thermal electron energy transfer into the subsystem (thermal electron, lattice, and spin), reveals that energy flow from non-thermal electrons plays a decisive role in determining the type I and II photoinduced spin dynamics behavior. Our finding proposes a new mechanism for understanding ultrafast remagnetization dynamics. © 2020, The Author(s).1

Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models

<p>Abstract</p> <p>Background</p> <p>Neuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammation caused memory impairments. In the present study, we investigated the possible preventive effects of 4-<it>O</it>-methylhonokiol, a constituent of <it>Magnolia officinalis</it>, on memory deficiency caused by LPS, along with the underlying mechanisms.</p> <p>Methods</p> <p>We investigated whether 4-<it>O</it>-methylhonokiol (0.5 and 1 mg/kg in 0.05% ethanol) prevents memory dysfunction and amyloidogenesis on AD model mice by intraperitoneal LPS (250 μg/kg daily 7 times) injection. In addition, LPS-treated cultured astrocytes and microglial BV-2 cells were investigated for anti-neuroinflammatory and anti-amyloidogenic effect of 4-<it>O</it>-methylhonkiol (0.5, 1 and 2 μM).</p> <p>Results</p> <p>Oral administration of 4-<it>O</it>-methylhonokiol ameliorated LPS-induced memory impairment in a dose-dependent manner. In addition, 4-<it>O</it>-methylhonokiol prevented the LPS-induced expression of inflammatory proteins; inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as activation of astrocytes (expression of glial fibrillary acidic protein; GFAP) in the brain. In <it>in vitro </it>study, we also found that 4-<it>O</it>-methylhonokiol suppressed the expression of iNOS and COX-2 as well as the production of reactive oxygen species, nitric oxide, prostaglandin E₂, tumor necrosis factor-α, and interleukin-1β in the LPS-stimulated cultured astrocytes. 4-<it>O</it>-methylhonokiol also inhibited transcriptional and DNA binding activity of NF-κB via inhibition of IκB degradation as well as p50 and p65 translocation into nucleus of the brain and cultured astrocytes. Consistent with the inhibitory effect on neuroinflammation, 4-<it>O</it>-methylhonokiol inhibited LPS-induced Aβ_1-42generation, β- and γ-secretase activities, and expression of amyloid precursor protein (APP), BACE1 and C99 as well as activation of astrocytes and neuronal cell death in the brain, in cultured astrocytes and in microglial BV-2 cells.</p> <p>Conclusion</p> <p>These results suggest that 4-<it>O</it>-methylhonokiol inhibits LPS-induced amyloidogenesis via anti-inflammatory mechanisms. Thus, 4-<it>O</it>-methylhonokiol can be a useful agent against neuroinflammation-associated development or the progression of AD.</p

Asymmetric TMO–Metal–TMO Structure for Enhanced Efficiency and Long-Term Stability of Si-Based Heterojunction Solar Cells

In this study, we fabricated Si-based heterojunction solar cells (HSCs) with an asymmetric TMO–metal–TMO (TMT) structure using both MoO3 and V2O5 as the hole-selective contacts. Our HSCs offer enhanced long-term stability and effective passivation for crystal defects on the Si sur-face. We analyzed the oxygen vacancy state and surface morphology of the MoO3- and V2O5-TMO thin films using X-ray photoelectron spectroscopy and atomic force microscopy to investigate their passivation characteristics for Si surface defects. From the measured minority carrier lifetime, V2O5 revealed a highly improved lifetime (590 μs) compared to that of MoO3 (122.3 μs). In addition, we evaluated the long-term stability of each TMO thin film to improve the operation stability of the HSCs. We deposited different types of TMOs as the top- and bottom-TMO layers and assessed the effect of the thickness of each TMO layer. The fabricated asymmetric TMT/Si HSCs showed noticeable improvements in efficiency (7.57%) compared to 6.29% for the conventional symmetric structure which used the same TMO material for both the top and bottom layers. Furthermore, in terms of long-term stability, the asymmetric TMT/Si HSCs demonstrated an efficiency that was 250% higher than that of symmetric TMT/Si HSCs, as determined via power conversion efficiency degradation over 2000 h which is mainly attributed by the lower oxygen vacancy of the top-TMO, V2O5. These results suggest that the asymmetric TMT structure is a promising approach for the fabrication of low-cost and high-efficiency Si-based HSCs with enhanced long-term stability

Synthesis of π-extended low bandgap polymer based on isoindigo and thienyl-vinylene for high-performance polymer solar cells

246th ACS National Meeting and Exposition September 8-12, 2013, Indianapolis, IndianaWe have synthesized PSSA-g-PANIs which are self-doped conducting copolymer and then prepared the composites with GO. When the transmittances of PSSA-g-PANI and its composites are compared with that of PEDOT:PSS, PSSA-g-PANI and its composite with a small amount of GO (2.5 wt%, 5 wt%) show higher transmittance than PEDOT:PSS in the range of 450 nm to 600 nm, corresponding to the absorption range of P3HT. The electrical conductivities of PSSA-g-PANI and its composite are much larger than that of PEDOT:PSS. The device with the pristine PSSA-g-PANI shows higher PCE than that with PEDOT:PSS mainly due to enhancement of JSC. When the composite with 2.5 wt% GO was used, the device exhibits the maximum PCE of 4.14%, which is 15% larger than the device with PEDOT:PSS.OAIID:oai:osos.snu.ac.kr:snu2013-01/104/0000001236/16SEQ:16PERF_CD:SNU2013-01EVAL_ITEM_CD:104USER_ID:0000001236ADJUST_YN:NEMP_ID:A004558DEPT_CD:445CITE_RATE:0FILENAME:배승환 포스터 초록.pdfDEPT_NM:재료공학부EMAIL:[email protected]:

The effects of hemp seed consumption on depression, anxiety and cognitive improvement based on machine learning

Background: Hemp seed (Cannabis sativa L.) is an annual herbaceous plant of the Cannabis genus that contains a large amount of protein, iron, and fatty acids, including linoleic, &alpha;-linolenic, and &gamma;-linolenic acid. These compounds are involved in a number of biological activities, including immunity enhancement, hyperlipidemia, and inflammation reduction. Here, we investigated the antioxidant effects of hemp seed on human cognitive function.Methods: The test was administered to 34 healthy volunteers aged &ge; 20 years. Participants were selected according to age and sex and were administered 10 g of hemp seed three times daily (30 g/day) for 45 days. The outcome measurements were recorded using a survey, computerized neurocognitive tests, and artificial intelligence.Results: Survey analysis determined that both the Beck Anxiety Inventory and Beck Depression Inventory measurements decreased significantly after hemp seed consumption when compared to measurements taken before consumption (p &lt; 0.05). Additionally, significant results were observed in the Stroop and Tower of London tasks (p &lt; 0.05). The prediction performance for the antidepressant effect was 0.83 for the area under the curve in the random forest algorithm, which was superior to that of other machine learning methods.&nbsp;Conclusion: These results suggest that hemp seeds have a beneficial effect on cognitive impairment

Layer-by-Layer Assembly for Graphene-based Multilayer Nanocomposites: Synthesis and Applications

Two-dimensional (2D) graphene sheets have become a versatile platform for the fabrication of innovative hybrid materials with various functions due to their unique electrical, optical, thermal, and mechanical properties. The preparation of graphene-based composites with nanoscale precision is highly important for reproducible and controllable performance through the analysis of interplay between each component. In particular, the layer-by-layer (LbL) assembly technique is known as a simple, inexpensive, and versatile process for the fabrication of highly ordered multilayer film structures from various types of materials. The LbL structures capable of controlling nanoscale composition and architectures are achieved through the sequential adsorption of oppositely charged components by attractive forces such as electrostatic interactions. In this review, we will focus on the recent progress in graphene-based nanocomposites hybridized with various nanomaterials such as carbon nanomaterials, polymers, and inorganic nanoparticles by the LbL assembly. Multilayered graphene nanocomposites exhibit improved physical/chemical properties and superior performance compared with the individual components due to the synergistic effects in various applications including electric devices, energy storage and conversion, and biological usages. &amp;#169; 2015 American Chemical Society.close2