AstroSat observation of rapid Type-I thermonuclear burst from the low mass X-ray binary GX 3+1

We report the results of an observation of low mass X-ray binary GX 3+1 with {\it AstroSat}'s Large Area X-ray Proportional Counter (LAXPC) and Soft X-ray Telescope (SXT) instruments on-board for the first time. We have detected one Type-1 thermonuclear burst ($\sim$ 15 s) present in the LAXPC 20 light curve, with a double peak feature at higher energies and our study of the hardness-intensity diagram reveals that the source was in a soft banana state. The pre-burst emission could be described well by a thermally Comptonised model component. The burst spectra is modelled adopting a time-resolved spectroscopic method using a single color blackbody model added to the pre-burst model, to monitor the parametric changes as the burst decays. Based on our time-resolved spectroscopy, we claim that the detected burst is a photospheric radius expansion (PRE) burst. During the PRE phase, the blackbody flux is found to be approximately constant at an averaged value $\sim$ 2.56 in $10^{-8}$ ergs s$^{-1}$ cm$^{-2}$ units. On the basis of literature survey, we infer that \textit{AstroSat}/LAXPC 20 has detected a burst from GX 3+1 after more than a decade which is also a PRE one. Utilising the burst parameters obtained, we provide a new estimation to the source distance, which is $\sim$ 9.3 $\pm$ 0.4 kpc, calculated for an isotropic burst emission. Finally, we discuss and compare our findings with the published literature reports.Comment: 14 pages, 10 figures, accepted for publication in The Journal of Astrophysics and Astronom

Study of P. falciparum-infected erythrocytes and induced anisotropies under optical and fluid forces

Background & objectives: The effect of P. falciparum on erythrocytes has been studied for a long time at the population level but actual studies at the single cell level remain largely unexplored. The aim of this study was to address the host-parasite relationship at the single cell level under two different kinds of forces, an optical force and a fluid force. The questions addressed were about the basic host-parasite interactions, but our findings have larger implications in diverse fields of parasite biology. Methods: Erythrocytes were monitored under optical forces (using optical tweezers) and fluid forces (using microfluidic chambers) and dynamical images were captured in real-time video clips. These videos were then split into their respective frames so as to yield temporal information and various parameters pertaining to membrane structure, ionic imbalance and interaction with different forces were studied. Results: The results of this study mainly bring to fore the inherent differences between infected and normal cell populations at the single cell level under various external forces. We probed three different criteria folding times, rotation speeds and rolling frequency to show inherent difference in various cell populations and also the dependence of the above to the cycle of the parasite. Interpretation & conclusion: This study portrays the importance of single cell observations pertaining to the host-parasite relationship. It shows the effect the malarial parasite has on erythrocytes and how the intrinsic property of the infected and its neighbouring uninfected cells change as compared to normal erythrocytes. There are thus implications in the fields of cytoadherence, parasite invasions and host immune evasion