The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research

In this study, we report the results of a comprehensive phenotyping of the retina of the AppNL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unafected in the AppNL-G-F mouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. These fndings suggest that the AppNL-G-F retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, ofers unique opportunities for drug discovery and fundamental research into preclinical AD

An unusual case of hypothermia associated with therapeutic doses of olanzapine: a case report

<p>Abstract</p> <p>Introduction</p> <p>We report a case of a 42-year-old man who had symptomatic hypothermia as a result of taking olanzapine for paranoid schizophrenia. According to published data, only a few cases of hypothermia associated with olanzapine have been reported since its introduction into clinical use.</p> <p>Case presentation</p> <p>A 42-year-old Sri Lankan man with schizophrenia who was being treated with a therapeutic dose of olanzapine presented with reduced level of consciousness. He had a core temperature of 32°C and was bradycardic. At the time of admission, the electrocardiogram showed sinus bradycardia with J waves. He did not have any risk factors for developing hypothermia except the use of olanzapine. There was improvement in his clinical condition with reversal of electrocardiogram changes following gradual rewarming and the omission of olanzapine.</p> <p>Conclusion</p> <p>Hypothermia induced by antipsychotic medications is not uncommon, but olanzapine-induced hypothermia is rare and occurrence has been reported during initiation or increasing the dose. But here the patient developed hypothermia without dose adjustment.</p

Very Wide Register: An Asymmetric Register File Organization for Low Power Embedded Processors

In current embedded systems processors, multi-ported register files are one of the most power hungry parts of the processor, even when they are clustered. This paper presents a novel register file architecture, which has single ported cells and asymmetric interfaces to the memory and to the datapath. Several realistic kernels from the TI DSP benchmark and from Software Defined Radio (SDR) are mapped on the architecture. A complete physical design of the architecture is done in TSMC 90nm technology. The novel architecture presented is shown to obtain energy gains of upto 10X with respect to conventional multi-ported register file over the different benchmarks

Impact of ILP-improving code transformations on loop buffer energy

For multimedia applications, loop buffering is an efficient mechanism to reduce the power in the instruction memory of embedded processors. In particular, software controlled clustered loop buffers are very energy efficient. However code transformations needed in VLIW compilers to reach a higher ILP potentially may have a large negative influence on the energy consumed in the instruction memories (including the loop buffer). This paper will show that such code transformations can also have a positive impact on the instruction memory energy of processors, if the transformations are steered taking into account the presence of the software controlled clustered loop buffer. We will propose guidelines to steer the code transformations and show that these guidlines should be differently applied in a system with clustered loop buffer than in a system with only a normal instruction cache. Results are presented for a mix of three important ILP code transformations: software-pipelining, if-conversion and loop unrolling. Results show an energy reduction between 15% and 25% and a delay reduction between 60% and 75% for an MPEG-2 Video Encoder benchmark