The Role of Small and Medium-size Enterprises (SMEs) in the Socio-economic Stability of Karachi.

The purpose of this study is to identify the core constraints in financing of SMEs in Karachi that impede their growth and even undermine their liquidity and financial position. Literature review: The problems and constraints are faced by small and medium-size enterprises (SMEs) in Karachi with regard to access to financing. Along with Karachi, the other cities and areas in Pakistan are facing alike problems. Methods: This study is exploratory in nature and includes quantitative and qualitative data. Data was collected through well designed questionnaire from a sample group of 500 respondents of SMEs in Karachi. In addition, one-on-one formal and informal interviews were also taken from various businessmen and bankers. Conceptual Model: A conceptual model/ framework were devised to test and ascertain the statistical validity of the study. It includes dependent variable SME financing, and independent variables, financing constraints, functional/ internal barriers, government support and incentives, and SMEs growth and development. Findings: The findings revealed that most people/ SMEs feel reluctant to borrow from banks and financial institutes because of stringent collateral requirements, high mark up, lengthy and convoluted documentary process, and to some extent malpractices at banks and financial institutions. The preference of the lending institutions is to finance the large-scale corporate sector. The results of the data analysis confirmed profound relation of dependent and independent variables and accepted the hypotheses. Conclusion: A substantial portion of SMEs possesses great potential of growth. There exists unending opportunities to tap, while banking and financial system in Karachi and Pakistan enjoys enough liquidity but SMEs are unable to enjoy financial leverage because of various financial constraints, lack of support by government institutions and policy makers, and internal weaknesses and flaws of SMEs in managing their businesses. Finally recommendations were lodged.Small and Medium enterprise; constraints in financing; Socio-economic Sustainability

The role of small and medium-size enterprises (SMEs) in the socio-economic stability of Karachi

Purpose: The purpose of this study is to identify the core constraints in financing of SMEs in Karachi that impede their growth and even undermine their liquidity and financial position. Literature review: The problems and constraints are faced by small and medium-size enterprises (SMEs) in Karachi with regard to access to financing. Along with Karachi, the other cities and areas in Pakistan are facing alike problems. Methods: This study is exploratory in nature and includes quantitative and qualitative data. Data was collected through well designed questionnaire from a sample group of 500 respondents of SMEs in Karachi. In addition, one-on-one formal and informal interviews were also taken from various businessmen and bankers. Conceptual Model: A conceptual model/ framework were devised to test and ascertain the statistical validity of the study. It includes dependent variable SME financing, and independent variables, financing constraints, functional/ internal barriers, government support and incentives, and SMEs growth and development. Findings: The findings revealed that most people/ SMEs feel reluctant to borrow from banks and financial institutes because of stringent collateral requirements, high mark up, lengthy and convoluted documentary process, and to some extent malpractices at banks and financial institutions. The preference of the lending institutions is to finance the large-scale corporate sector. The results of the data analysis confirmed profound relation of dependent and independent variables and accepted the hypotheses. Conclusion: A substantial portion of SMEs possesses great potential of growth. There exists unending opportunities to tap, while banking and financial system in Karachi and Pakistan enjoys enough liquidity but SMEs are unable to enjoy financial leverage because of various financial constraints, lack of support by government institutions and policy makers, and internal weaknesses and flaws of SMEs in managing their businesses. Finally recommendations were lodged.Small and Medium enterprise; constraints in financing; Socio-economic Sustainability

Generating background network traffic for network security testbeds

With the advancement of science and technology, there has been a rapid growth in computer network attacks. Most of them are in the form of sophisticated and smart attacks, which are hard to trace. Although researchers have been working on this issue - attack detection, prevention and mitigation - the existing network security evaluation techniques lack effective experimental infrastructure and rigorous scientific methodologies for developing and testing the cyber security technologies. To make progress in this area, we need to address one of the major shortcomings in evaluating network security mechanisms -- lack of relevant, representative network data. The research community is in need of tools that are able to generate scalable, tunable, and representative network traffic. Such tools are vital in a tested environment, where they can be used to evaluate the behavior and performance of security related tools. In this context, we present the Markov Traffic Generator (MTG), which is able to generate representative network traffic. The MTG follows a unique approach of generating background traffic at the session level, unlike the previous approaches operated on the packet level. The tool is application dependent and is able to generate various types of TCP traffic. The resulting tool is useful for researchers and developers in building, testing and evaluating cyber security related tools. In this work, we develop the classifications of background traffic generation models based on the past work and present a new toolkit, the Markov Traffic Generator (MTG). As opposed to past work, MTG uses a first order hierarchical Markov agent to generate background user behavior in network testbed. The Markov agents can be used to generate behavior that mimics observed traffic in real networks. The thesis concludes by showing that MTG can realistically replicate observed network behavior

E. coli-quantum dot bioconjugates as whole-cell fluorescent reporters for probing cellular damage

A quantum dot (QD) conjugated whole-cell E. coli biosensor (E. coli–QD bioconjugates) was developed as a new molecular tool for probing cellular damage. The E. coli–QD bioconjugates were viable and exhibited fluorescence emission at 585 nm. Scanning electron microscopy (SEM) analysis of E. coli–QD bioconjugates revealed that the QDs were immobilized on the cell-surfaces and the fluorescence emission from QDs present on cell-surfaces was visualized by confocal microscopic examination. The E. coli–QD bioconjugates were employed as whole-cell fluorescent reporters that were designed to function as fluorescence switches that turn-off when cellular damage occurs. In this study, multi-walled carbon nanotubes (CNTs) were utilized as a model nanomaterial to probe cellular damage. Fluorescence spectra were recorded after the exposure of E. coli–QD bioconjugates with CNTs. We observed a strong correlation between fluorescence emission spectra, SEM and confocal microscopic analysis demonstrating that CNTs induced a dose and exposure time-dependent cellular toxicity. This toxicity mainly occurred by the physical interaction and cellular trafficking mechanisms that led to the collapse of the cellular structure and thus loss of fluorescence. The responses of E. coli–QD bioconjugates against CNTs were also visualized by simply exposing the cells to UV light and therefore rapid toxicity analysis and screening can be made. Our study demonstrated an easy and simple method to determine an important mechanistic perspective for the biological toxicity of chemicals or nanomaterials (NMs)

Biosensors for cardiac biomarkers detection: a review

The cardiovascular disease (CVD) is considered as a major threat to global health. Therefore, there is a growing demand for a range of portable, rapid and low cost biosensing devices for the detection of CVD. Biosensors can play an important role in the early diagnosis of CVD without having to rely on hospital visits where expensive and time-consuming laboratory tests are recommended. Over the last decade, many biosensors have been developed to detect a wide range of cardiac marker to reduce the costs for healthcare. One of the major challenges is to find a way of predicting the risk that an individual can suffer from CVD. There has been considerable interest in finding diagnostic and prognostic biomarkers that can be detected in blood and predict CVD risk. Of these, C-reactive protein (CRP) is the best known biomarker followed by cardiac troponin I or T (cTnI/T), myoglobin, lipoprotein-associated phospholipase A(2), interlukin-6 (IL-6), interlukin-1 (IL-1), low-density lipoprotein (LDL), myeloperoxidase (MPO) and tumor necrosis factor alpha (TNF-α) has been used to predict cardiovascular events. This review provides an overview of the available biosensor platforms for the detection of various CVD markers and considerations of future prospects for the technology are addressed

Ecological Study of Vanellus indicus in District Narowal, Pakistan

Red wattled lapwing is commonly found and endemic species of Asian agricultural lands. Its preferred habitat is airy lands, rural and even urban areas. The main aims of current investigatory effort were the observation of different parameters of breeding ecology of Vanellus indicus including breeding sites, incubation period, the clutch size, survival rate of chicks and possible reasons of their mortality which are localized in Narowal district. Red wattled lapwings forage on several types of insects, snails, seeds, and of invertebrates. Experimental observations highlight that the annual breeding season is of average 26-30 days of V. Indicus begins from the March and till the end of August. Moreover, the weight of their eggs falls between 22.0 to 28.0g. These findings about local species may serve for next experimental designs based of on V. indicus and further focus should be on those factors which may improve its breeding. Similarly, the estimation of feeding preferences of this species can directly help in low cost biological control management for crops

Messages in Cosmophilia: The “Love of Ornament” in Islamic Architecture

Islamic architecture is predominantly rich in ornamentation, and therefore, perfectly epitomizes the phenomenon of “cosmophilia” – meaning “love of ornament.” Taking this association as a point of departure, this article focuses on broadly identifying notions of cosmophilia in Islamic monuments that offer the finest and most varied examples of architectural ornamentation. In Islamic structures, where singular and unique ornamental devices can be located, the artistic programs of several monuments are concurrently found to be characterized by the “repeat ornament” – decorative elements replicated many times to envelope the façades in entirety. In this article, a variety of structures, erected under different dynastic polities from the medieval and early modern Islamic world, have been examined to understand the connotations and meanings attached to the Islamic ornaments. This will be done by looking at figural imageries, geometric and vegetal motifs, calligrams synthesizing images and texts, as well as structural and non-structural components integrated into the historic structures for aesthetic purposes. The ultimate goal of this study is to attempt an interpretation of the concepts and in some cases philosophical undertones, that were meant to be communicated through the Islamic architectural ornaments

Epidemiology of Oral Cancer in Pakistan

Oral carcinoma is one of the most frequently reported form of cancer in Pakistan. In time oncogenic prognosis facilities are still available in various regions countrywide. Provincial comparison indicates that more than 67% cases of oral squamous cancer are reported from Punjab whereas ratio in KPK is also high than Sindh and Baluchistan. The prevalence of this growing ailment can be minimized only by collaborative efforts of both government and general public regarding awareness of oral hygiene, causes of oral and esophageal carcinogenesis, early symptoms of this disease and its management.  &nbsp