Functionalization of carboxylated multiwall nanotubes with imidazole derivatives and their toxicity investigations

Imidazoles and their derivatives are compounds with chemotherapeutic applications. In this study, we investigated the chemical functionalization of carboxylated multiwalled carbon nanotubes (MWNT–COOH) by 1,2-phenylendiamine. Multiwalled nanotube (MWNT)–benzimidazole was obtained by an MWNT–amide reaction with POCl3 after 72 hours, which was confirmed by Fourier transform infrared, scanning electron microscopy, thermal gravimetric analysis, and elemental analysis. These functionalizations were chosen due to -NH2 and NHCO active sites in MWNT–amide for future application. Toxicity assays with fibroblast cells and MTT test for measurement of viable cell numbers were also performed. Cellular results did not show any toxicity change in modified samples from that of the reference samples

H<sub>2</sub>TPP Organocatalysis in Mild and Highly Regioselective Ring Opening of Epoxides to Halo Alcohols by Means of Halogen Elements

We found that elemental iodine and bromine are converted to trihalide nucleophiles (triiodine and tribromide anion, respectively) in the presence of catalytic amounts of <em>meso</em>-tetraphenylporphyrins (H<sub>2</sub>TPP). Therefore a highly regioselective method for the synthesis of b-haloalcohols through direct ring opening of epoxides with elemental iodine and bromine in the presence of H<sub>2</sub>TPPs as new catalysts is described. At room temperature a series of epoxide derivatives were converted into the corresponding halohydrins resulting from an attack of trihalide species anion atoms at the less substituted carbon atom. This method occurs under neutral and mild conditions with high yields in various aprotic solvents, even when sensitive functional groups are present

Electrocatalytic multicomponent assembling of aminouracils, aldehydes and malononitrile: An efficient approach to 7-amino-pyrido[2,3-d]pyrimidine-6-carbonitrile derivatives

Electrocatalytic multicomponent transformation of 6-aminouracils, aromatic aldehydes and malononitrile in ethanol in an undivided cell in the presence of potassium bromide as an electrolyte leads to 7-amino-pyrido[2,3- d]pyrimidine-6-carbonitrile derivatives in short reaction times (8-20 min) and good to high yields (70-86%)

Functionalization of carboxylated multiwall nanotubes with imidazole derivatives and their toxicity investigations

Javad Azizian1, Hasan Tahermansouri1, Esmaeil Biazar2, Saeed Heidari3, Davood Chobfrosh Khoei11Department of Chemistry, Science and Research branch, Islamic Azad University, Ponak, Tehran, Iran; 2Young researchers club – Islamic Azad University, Tonekabon Branch, Iran; 3Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshty University of Medical Sciences,Tehran, IranAbstract: Imidazoles and their derivatives are compounds with chemotherapeutic applications. In this study, we investigated the chemical functionalization of carboxylated multiwalled carbon nanotubes (MWNT–COOH) by 1,2-phenylendiamine. Multiwalled nanotube (MWNT)–benzimidazole was obtained by an MWNT–amide reaction with POCl3 after 72 hours, which was confirmed by Fourier transform infrared, scanning electron microscopy, thermal gravimetric analysis, and elemental analysis. These functionalizations were chosen due to -NH2 and NHCO active sites in MWNT–amide for future application. Toxicity assays with fibroblast cells and MTT test for measurement of viable cell numbers were also performed. Cellular results did not show any toxicity change in modified samples from that of the reference samples.Keywords: functionalization, 1,2-phenylendiamine, carboxylated multiwall nanotubes, toxicit

<i>Ab initio </i>and MNDO study of structural parameters and pyramidal phosphorus <span style="font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-IN;mso-fareast-language: EN-IN;mso-bidi-language:AR-SA" lang="EN-IN">atom inversion in 1-substituted phosphorinanes</span>

660-663<span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-in;mso-fareast-language:en-in;mso-bidi-language:ar-sa"="" lang="EN-IN">A detailed ab initio and MNDO study of structural parameters and pyramidal phosphorus atom inversion and also enthalpy differences <span style="mso-bidi-font-style: italic">(∆Ho) between the participants in the conformational equilibrium...</span

Synthesis of some new 1-methyl-3<i>'</i>, 3<i>'</i>-dichlorospiro[indol-3, 4<i>'</i>-azetidine]-2(3<i>H</i>), 2<i>'</i>-diones and bis[1-methyl-3<i>'</i>, 3<i>'</i>-dichlorospiro(indole-3, 4<i>'</i> -azetidine)-2(3<i>H</i>)<i>,</i>2<i>'</i>-diones]

304-307The title spirodichloroazetidinones are prepared by cyclocondensation of isatin-3-anils or isatin diimines with dichloroacetyl chloride in the presence of triethylamine in excellent yields