Achieving better than 1 minute accuracy in the Heliocentric and Barycentric Julian Dates

As the quality and quantity of astrophysical data continue to improve, the precision with which certain astrophysical events can be timed becomes limited not by the data themselves, but by the manner, standard, and uniformity with which time itself is referenced. While some areas of astronomy (most notably pulsar studies) have required absolute time stamps with precisions of considerably better than 1 minute for many decades, recently new areas have crossed into this regime. In particular, in the exoplanet community, we have found that the (typically unspecified) time standards adopted by various groups can differ by as much as a minute. Left uncorrected, this ambiguity may be mistaken for transit timing variations and bias eccentricity measurements. We argue that, since the commonly-used Julian Date, as well as its heliocentric and barycentric counterparts, can be specified in several time standards, it is imperative that their time standards always be reported when accuracies of 1 minute are required. We summarize the rationale behind our recommendation to quote the site arrival time, in addition to using BJD_TDB, the Barycentric Julian Date in the Barycentric Dynamical Time standard for any astrophysical event. The BJD_TDB is the most practical absolute time stamp for extra-terrestrial phenomena, and is ultimately limited by the properties of the target system. We compile a general summary of factors that must be considered in order to achieve timing precisions ranging from 15 minutes to 1 microsecond. Finally, we provide software tools that, in principal, allow one to calculate BJD_TDB to a precision of 1 microsecond for any target from anywhere on Earth or from any spacecraft.Comment: Online BJD_TDB calculator at http://astroutils.astronomy.ohio-state.edu/time/utc2bjd.html. PASP accepted, 11 pages, 6 figures, updated to match published versio

Method of improving tolerance of plants to herbicides using seed insecticide treatments

Methods of increasing the tolerance of a plant to an herbicide and seeds for carrying out these methods are provided herein. The methods include treating the seeds of the plant with an insecticide prior to planting. The insecticide treatment makes the resulting plant more resistant to herbicides and in particular to post-emergence herbicides as compared to untreated seeds. The plants suitably do not have complete natural or complete engineered resistance to the herbicide. The treated seeds are then planted in a field and the herbicide is applied to the field. The resulting plants growing from the treated seeds have increased tolerance to the herbicide as compared to plants grown from seeds not treated with the insecticide

Logical Activation Functions: Logit-space equivalents of Probabilistic Boolean Operators

The choice of activation functions and their motivation is a long-standing issue within the neural network community. Neuronal representations within artificial neural networks are commonly understood as logits, representing the log-odds score of presence of features within the stimulus. We derive logit-space operators equivalent to probabilistic Boolean logic-gates AND, OR, and XNOR for independent probabilities. Such theories are important to formalize more complex dendritic operations in real neurons, and these operations can be used as activation functions within a neural network, introducing probabilistic Boolean-logic as the core operation of the neural network. Since these functions involve taking multiple exponents and logarithms, they are computationally expensive and not well suited to be directly used within neural networks. Consequently, we construct efficient approximations named $\text{AND}_\text{AIL}$ (the AND operator Approximate for Independent Logits), $\text{OR}_\text{AIL}$, and $\text{XNOR}_\text{AIL}$, which utilize only comparison and addition operations, have well-behaved gradients, and can be deployed as activation functions in neural networks. Like MaxOut, $\text{AND}_\text{AIL}$ and $\text{OR}_\text{AIL}$ are generalizations of ReLU to two-dimensions. While our primary aim is to formalize dendritic computations within a logit-space probabilistic-Boolean framework, we deploy these new activation functions, both in isolation and in conjunction to demonstrate their effectiveness on a variety of tasks including image classification, transfer learning, abstract reasoning, and compositional zero-shot learning

Galactic Center Pulsars with the ngVLA

Pulsars in the Galactic Center (GC) are important probes of General Relativity, star formation, stellar dynamics, stellar evolution, and the interstellar medium. Despite years of searching, only a handful of pulsars in the central 0.5 deg are known. The high-frequency sensitivity of ngVLA will open a new window for discovery and characterization of pulsars in the GC. A pulsar in orbit around the GC black hole, Sgr A*, will provide an unprecedented probe of black hole physics and General Relativity.Comment: To be published in the ASP Monograph Series, "Science with a Next-Generation VLA", ed. E. J. Murphy (ASP, San Francisco, CA

Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer

Transposon mutagenesis is a widely applied and powerful genetic tool for the discovery of genes associated with selected phenotypes. Chlamydia trachomatis is a clinically significant, obligate intracellular bacterium for which many conventional genetic tools and capabilities have been developed only recently. This report describes the successful development and application of a Himar transposon mutagenesis system for generating single-insertion mutant clones of C. trachomatis. This system was used to generate a pool of 105 transposon mutant clones that included insertions in genes encoding flavin adenine dinucleotide (FAD)-dependent monooxygenase (C. trachomatis 148 [ct148]), deubiquitinase (ct868), and competence-associated (ct339) proteins. A subset of Tn mutant clones was evaluated for growth differences under cell culture conditions, revealing that most phenocopied the parental strain; however, some strains displayed subtle and yet significant differences in infectious progeny production and inclusion sizes. Bacterial burden studies in mice also supported the idea that a FAD-dependent monooxygenase (ct148) and a deubiquitinase (ct868) were important for these infections. The ct339 gene encodes a hypothetical protein with limited sequence similarity to the DNA-uptake protein ComEC. A transposon insertion in ct339 rendered the mutant incapable of DNA acquisition during recombination experiments. This observation, along with in situ structural analysis, supports the idea that this protein is playing a role in the fundamental process of lateral gene transfer similar to that of ComEC. In all, the development of the Himar transposon system for Chlamydia provides an effective genetic tool for further discovery of genes that are important for basic biology and pathogenesis aspects.S.D.L., Z.E.D., K.S.H., S.B., R.J.S., and P.S.H. were funded by NIH (AI126785)J.W. and P.S.H. were supported by NIH AI125929. P.S.H. was also supported by P20GM113117Support for genomic sequencing was supplemented by P20GM10363

Integrated Resistance and Aerobic Training Maintains Cardiovascular and Skeletal Muscle Fitness During 14 Days of Bed Rest

Background: Known incompatibilities exist between resistance and aerobic training. Of particular importance are findings that concurrent resistance and aerobic training reduces the effectiveness of the resistance training and limits skeletal muscle adaptations (example: Dudley & Djamil, 1985). Numerous unloading studies have documented the effectiveness of resistance training alone for the maintenance of skeletal muscle size and strength. However the practical applications of those studies are limited because long ]duration crew members perform both aerobic and resistance exercise throughout missions/spaceflight. To date, such integrated training on the International Space Station (ISS) has not been fully effective in the maintenance of skeletal muscle function. Purpose: The purpose of this study was to evaluate the efficacy of high intensity concurrent resistance and aerobic training for the maintenance of cardiovascular fitness and skeletal muscle strength, power and endurance over 14 days of strict bed rest. Methods: 9 subjects (8 male and 1 female; 34.5 +/- 8.2 years) underwent 14 days of bed rest with concurrent training. Resistance and aerobic training were integrated as shown in table 1. Days that included 2 exercise sessions had a 4-8 hour rest between exercise bouts. The resistance training consisted of 3 sets of 12 repetitions of squat, heel raise, leg press and hamstring curl exercise. Aerobic exercise consisted of periodized interval training that included 30 sec, 2 min and 4 min intervals alternating by day with continuous aerobic exercise