It\u27s Fun, But Is It Science? Goals and Strategies in a Problem-Based Learning Course

All students at Hampshire College must complete a science requirement in which they demonstrate their understanding of how science is done, examine the work of science in larger contexts, and communicate their ideas effectively. Human Biology: Selected Topics in Medicine is one of 18-20 freshman seminars designed to move students toward completing this requirement. Students work in cooperative groups of 4-6 people to solve actual medical cases about which they receive information progressively. Students assign themselves homework tasks to bring information back for group deliberation. The goal is for case teams to work cooperatively to develop a differential diagnosis and recommend treatment. Students write detailed individual final case reports. Changes observed in student work over six years of developing this course include: increased motivation to pursue work in depth, more effective participation on case teams, increase in critical examination of evidence, and more fully developed arguments in final written reports. As part of a larger study of eighteen introductory science courses in two institutions, several types of pre- and post-course assessments were used to evaluate how teaching approaches might have influenced students’ attitudes about science, their ability to learn science, and their understanding of how scientific knowledge is developed [1]. Preliminary results from interviews and Likert-scale measures suggest improvements in the development of some students’ views of epistemology and in the importance of cooperative group work in facilitating that development

Organosolv pretreatment of Sitka spruce wood: conversion of hemicelluloses to ethyl glycosides

A range of organosolv pretreatments, using ethanol:water mixtures with dilute sulphuric acid, were applied to Sitka spruce sawdust with the aim of generating useful co-products as well as improving saccharification yield. The most efficient of the pretreatment conditions, resulting in subsequent saccharification yields of up to 86%, converted a large part of the hemicellulose sugars to their ethyl glycosides as identified by GC/MS. These conditions also reduced conversion of pentoses to furfural, the ethyl glycosides being more stable to dehydration than the parent pentoses. Through comparison with the behaviour of model compounds under the same reaction conditions it was shown that the anomeric composition of the products was consistent with a predominant transglycosylation reaction mechanism, rather than hydrolysis followed by glycosylation. The ethyl glycosides have potential as intermediates in the sustainable production of high-value chemicals

Isolation of high quality lignin as a by-product from ammonia percolation pretreatment of poplar wood

A two-step process combining percolation-mode ammonia pretreatment of poplar sawdust with mild organosolv purification of the extracted lignin produced high quality, high purity lignin in up to 31% yield and 50% recovery. The uncondensed fraction of the isolated lignin was up to 34%, close to that the native lignin (40%). Less lignin was recovered after pretreatment in batch mode, apparently due to condensation during the longer residence time of the solubilised lignin at elevated temperature. The lignin recovery was directly correlated with its molecular weight and its nitrogen content. Low nitrogen incorporation, observed at high ammonia concentration, may be explained by limited homolytic cleavage of -O-4 bonds. Ammonia concentrations from 15% to 25% (w/w) gave similar results in terms of lignin structure, yield and recovery

Kinetic study of adsorption and photo-decolorization of Reactive Red 198 on TiO2 surface

Recycling and reuse of wastewater after purification will reduce the environmental pollution as well as fulfill the increasing demand of water. Adsorption-based water treatment process is very popular for dye-house wastewater treatment. The present study deals with treatment of wastewater contaminated by reactive dye. TiO2 is used as adsorbent and the spent adsorbent has been regenerated by Advanced Oxidation Process (AOP), without using any other chemicals. TiO2 adsorbs dye molecules and then those dye molecules have been oxidized via a photocatalytic reaction in presence of UV irradiation. Kinetics of dye adsorption and photocatalytic oxidation reaction has been developed in this study. Photocatalyst adsorbent (TiO2) has been reused several times after regeneration. The activity of catalyst decreases after each cycle; due to poisoning cause by intermediate by-products. Kinetic of this catalyst deactivation has been incorporated with L–H model to develop the photocatalytic reaction kinetic model

Resource acquisition, distribution and end-use efficiencies and the growth of industrial society

A key feature of the growth of industrial society is the acquisition of increasing quantities of resources from the environment and their distribution for end use. With respect to energy, growth has been near exponential for the last 160 years. We attempt to show that the global distribution of resources that underpins this growth may be facilitated by the continual development and expansion of near optimal directed networks. If so, the distribution efficiencies of these networks must decline as they expand due to path lengths becoming longer and more tortuous. To maintain long-term exponential growth the physical limits placed on the distribution networks appear to be counteracted by innovations deployed elsewhere in the system: namely at the points of acquisition and end use. We postulate that the maintenance of growth at the specific rate of ~2.4% yr−1 stems from an implicit desire to optimise patterns of energy use over human working lifetimes

Liver X receptors and male (in)fertility

Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in metabolically active tissues and the latter more ubiquitously. Both are activated by oxidised cholesterol metabolites, endogenously produced oxysterols. LXRs have important roles in lipid metabolism and inflammation, plus a number of newly emerging roles. They are implicated in regulating lipid balance in normal male reproductive function and may provide a link between male infertility and lipid disorders and/or obesity. Studies from Lxr knockout mouse models provide compelling evidence to support this. More recently published data suggest distinct and overlapping roles of the LXR isoforms in the testis and recent evidence of a role for LXRs in human male fertility. This review summarises the current literature and explores the likely link between LXR, lipid metabolism and male fertility as part of a special issue on Liver X receptors in International Journal of Molecular Sciences

A note on monopole moduli spaces

We discuss the structure of the framed moduli space of Bogomolny monopoles for arbitrary symmetry breaking and extend the definition of its stratification to the case of arbitrary compact Lie groups. We show that each stratum is a union of submanifolds for which we conjecture that the natural $L^2$ metric is hyperKahler. The dimensions of the strata and of these submanifolds are calculated, and it is found that for the latter, the dimension is always a multiple of four.Comment: 17 pages, LaTe

The acute effects of heavy sled towing on subsequent sprint acceleration performance

Objectives: The purpose of this study was to assess the practical use of heavy sled towing and its acute implications on subsequent sprint acceleration performance. Design and Methods: Eight healthy male varsity team sport athletes (age: 21.8±1.8years, height: 185.5±5.0cm, weight: 88.8±15.7kg, 15m sprint time: 2.66±0.13s) performed sprints under three separate weighted sled towing conditions in a randomized order. Each condition consisted of one baseline unweighted sprint (4-min pre), the sled towing sprint protocol: (1) 1x50% body mass, (2) 2x50% body mass, (3) 3x50% body mass (multiple sprints interspersed with 90s recovery), and 3 post-testing unweighted sprints thereafter (4, 8, 12-min post). All sprints were conducted over a 15m distance. Results: Significantly faster sprint times for the 3x sled towing protocol were identified following 8-min of rest (p=0.025, d=0.46, 2.64±0.15s to 2.57±0.17s). When individual best sprint times were analyzed against baseline data, significantly faster sprint times were identified following both 1x (p=0.007, d=0.69, 2.69±0.07s to 2.64±0.07s) and 3x (p=0.001, d=0.62, 2.64±0.15s to 2.55±0.14s) sled towing protocols. Within the 3x condition, all athletes achieved fastest sprint times following 8–12 min of rest. Conclusions: The findings from the present study indicate that a repeated bout of sled towing (3x50% body mass) leads to the enhancement in subsequent sprint acceleration performance, following adequate, and individualized recovery periods

Editorial: Improving urban regeneration and renewal outcomes by engaging an urban psychology

A crisis in mental health, especially in economically deprived neigh bour hoods, can present a significant barrier to successful urban regeneration projects. It follows that urban regeneration not only has a stake in promoting mental health care generally but, through its place making influence on physical and social structures, has a more direct responsibility to address poor mental health and sustain well-being where it exists. In support of a psychologically informed urban regeneration, this Special Issue sets out the case for a systematised intellectual and practice-based discipline and movement: An urban psychology, with an explicit therapeutic mission. It incorporates 10 articles delivered initially at Europe’s first urban psychology summit — City, Psychology, Place — held at the University of Liverpool in London campus in June 2019. In this editorial introduction, we reflect upon the need for an urban psychology at this historical juncture and offer our views on the work which such a body of practical knowledge might do to improve regeneration and renewal outcomes. We conclude that there can be no enduring economic, social or physical regeneration of distressed, failing or failed communities unless there is first ‘regeneration in support of life itself’ (RISLI)