Neurobiological Correlates of Decision-Making in Framing Conditions

Human decision-making is a complex process, of which the neurobiological correlates are not well understood. Several theories have been proposed, among others Prospect theory which assumes a different evaluation of gains and losses of the same value. De Martino et al. tested the influence of the “framing effect” on decision-making and we aimed to replicate their study as some of the findings remained unclear. A general tendency to act in accordance with the frame was shown in a behavioural study. In order to uncover the underlying neural correlates, participants performed the same task in an fMRI scanner. Even though the amygdala could not be linked to framing, increased activity in the ACC when making frame-incongruent decisions was established. This can be related to acting in a more rational manner. Furthermore, activity in the cerebellum was increased when making a choice, indicating the involvement of this brain area in decision-making under uncertainty

Resting-state functional connectivity in adults with 47,XXX:a 7 Tesla MRI study

Triple X syndrome is a sex chromosomal aneuploidy characterized by the presence of a supernumerary X chromosome, resulting in a karyotype of 47,XXX in affected females. It has been associated with a variable cognitive, behavioral, and psychiatric phenotype, but little is known about its effects on brain function. We therefore conducted 7 T resting-state functional magnetic resonance imaging and compared data of 19 adult individuals with 47,XXX and 21 age-matched healthy control women using independent component analysis and dual regression. Additionally, we examined potential relationships between social cognition and social functioning scores, and IQ, and mean functional connectivity values. The 47,XXX group showed significantly increased functional connectivity of the fronto-parietal resting-state network with the right postcentral gyrus. Resting-state functional connectivity (rsFC) variability was not associated with IQ and social cognition and social functioning deficits in the participants with 47,XXX. We thus observed an effect of a supernumerary X chromosome in adult women on fronto-parietal rsFC. These findings provide additional insight into the role of the X chromosome on functional connectivity of the brain. Further research is needed to understand the clinical implications of altered rsFC in 47,XXX