Mechanisms underlying alcohol-approach action tendencies: the role of emotional primes and drinking motives

Mechanisms underlying alcohol-approach action tendencies: the role of emotional primes and drinking motives Cousijn, J.; Luijten, M.; Wiers, R.W.H.J. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. The tendency to approach alcohol-related stimuli is known as the alcohol-approach bias and has been related to heavy alcohol use. It is currently unknown whether the alcohol-approach bias is more pronounced after emotional priming.The main aim of this study was to investigate whether positive and negative emotional primes would modulate the alcohol-approach bias. For this purpose, a new contextual emotional prime-approach avoidance task was developed, containing both negative and positive emotional primes. Explicit coping drinking motives were expected to be related to an increased alcohol-approach bias after negative primes. Results of 65 heavy and 50 occasional drinkers showed that the alcohol-approach bias was increased in both groups during negative emotional priming. This appeared to be due to slower alcohol avoidance rather than faster alcohol approach. This change in alcohol-approach bias was positively related to explicit enhancement drinking motives and negatively related to alcohol use-related problems. A stronger alcohol-approach bias in heavy compared to occasional drinkers could not be replicated here, and coping drinking motives were not related to the alcohol-approach bias in any of the emotional contexts. The current findings suggest that both occasional and heavy drinkers have a selective difficulty to avoid alcohol-related cues in a negative emotional context. Negative reinforcement may therefore be involved in different types of drinking patterns. The influence of emotional primes on alcohol-related action tendencies may become smaller when alcohol use becomes more problematic, which is in line with habit accounts of addiction

Does nitrous oxide addiction exist?:An evaluation of the evidence for the presence and prevalence of substance use disorder symptoms in recreational nitrous oxide users

BACKGROUND: Prevalence of nitrous oxide (N 2 O) use appears to be increasing in numerous countries worldwide, and excessive use has been associated with physical and mental problems. Because there currently is no consensus whether N 2 O has addictive potential, we aimed to evaluate the evidence for the presence and prevalence of DSM-5 substance use disorder (SUD) symptoms in N 2 O users. ANALYSIS: A literature search was conducted to assess the evidence for the presence of any of the 11 DSM-5 SUD symptoms in N 2 O users and the prevalence experiencing those symptoms. A substantial part of the studied N 2 O users use more than intended (i.e. 46% to 98%) and spend a substantial amount of time using N 2 O. At least some of the studied N 2 O users experience interpersonal problems (i.e. 13% to 80%) and use N 2 O in risky situations, such as driving under the influence. Evidence for the other criteria is either insufficient or inconclusive. CONCLUSIONS: The literature base for the presence and prevalence of DSM-5 substance use disorder (SUD) symptoms in nitrous oxide (N 2 O) users is limited and largely consists of qualitative studies and case studies, but it provides consistent evidence for the presence of at least four SUD criteria in heavy N 2 O users. N 2 O could well be addictive and should be treated as a potentially addictive substance until systematic assessments can provide evidence-based guidance to users, healthcare professionals and legislators. </p

Recent Evidence on the Relation Between Cannabis Use, Brain Structure, and Function: Highlights and Challenges

Purpose of ReviewThis narrative review provides an update of our knowledge on the relation between heavy cannabis use and cannabis use disorder (CUD) and the brain based on (f)MRI studies conducted in the past 5 years.Recent FindingsHeavy cannabis use and CUD are associated with structural brain changes—particularly volume—as well as altered resting-state functional connectivity (RSFC) in several networks and regions. Task-based fMRI studies reveal altered activity and connectivity in cannabis users compared to controls, but consistency of the results is domain dependent. Heaviness of use, CUD status, age, sex, and tobacco co-use are important potential moderators of the effects of cannabis on the brain.SummaryHeavy cannabis use and CUD are associated with differences in brain structure and function, but causality remains unclear, and long-term effects following abstinence require further investigation. Considering moderators of the effects of cannabis on the brain is crucial to further assess individual differences in the impact of cannabis use

Cannabis research in context:The case for measuring and embracing regional similarities and differences

Considerable differences in the types of cannabis products, methods of use, social norms and cultures and legal climates surrounding use exist among regions, resulting in distinct cannabis use contexts. Research examining and accounting for these contextual differences is crucial to further understanding cannabis use and cannabis use disorder, and for developing and refining context sensitive strategies for prevention, treatment and harm reduction

Recommendations for International gambling harm-minimisation guidelines: comparison with effective public health policy

Problem gambling represents a significant public health problem, however, research on effective gambling harm-minimisation measures lags behind other fields, including other addictive disorders. In recognition of the need for consistency between international jurisdictions and the importance of basing policy on empirical evidence, international conventions exist for policy on alcohol, tobacco, and illegal substances. This paper examines the evidence of best practice policies to provide recommendations for international guidelines for harm-minimisation policy for gambling, including specific consideration of the specific requirements for policies on Internet gambling. Evidence indicates that many of the public health policies implemented for addictive substances can be adapted to address gambling-related harms. Specifically, a minimum legal age of at least 18 for gambling participation, licensing of gambling venues and activities with responsible gambling and consumer protection strategies mandated, and brief interventions should be available for those at-risk for and experiencing gambling-related problems. However, there is mixed evidence on the effectiveness of limits on opening hours and gambling venue density and increased taxation to minimise harms. Given increases in trade globalisation and particularly the global nature of Internet gambling, it is recommended that jurisdictions take actions to harmonise gambling public health policies

From everyday life to measurable problematic smartphone use:The development and validation of the Smartphone Use Problems Identification Questionnaire (SUPIQ)

BACKGROUND AND AIMS: Problematic smartphone use (PSU) has gained attention, but its definition remains debated. This study aimed to develop and validate a new scale measuring PSU-the Smartphone Use Problems Identification Questionnaire (SUPIQ).METHODS: Using two separate samples, a university community sample (N = 292) and a general population sample (N = 397), we investigated: (1) the construct validity of the SUPIQ through exploratory and confirmatory factor analyses; (2) the convergent validity of the SUPIQ with correlation analyses and the visualized partial correlation network analyses; (3) the psychometric equivalence of the SUPIQ across two samples through multigroup confirmatory factor analyses; (4) the explanatory power of the SUPIQ over the Short Version of Smartphone Addiction Scale (SAS-SV) with hierarchical multiple regressions.RESULTS: The results showed that the SUPIQ included 26 items and 7 factors (i.e., Craving, Coping, Habitual Use, Social Conflicts, Risky Use, Withdrawal, and Tolerance), with good construct and convergent validity. The configural measurement invariance across samples was established. The SUPIQ also explained more variances in mental health problems than the SAS-SV.DISCUSSION AND CONCLUSIONS: The findings suggest that the SUPIQ shows promise as a tool for assessing PSU. Further research is needed to enhance and refine the SUPIQ as well as to investigate its clinical utility.</p

Alcohol cue reactivity in the brain:Age-related differences in the role of social processes in addiction in male drinkers

Social attunement (SA)-the tendency to harmonize behavior with the social environment-has been proposed to drive the escalation of alcohol use in adolescence, while reducing use in adulthood. Little is known about how heightened social sensitivity in adolescence may interact with neural alcohol cue reactivity-a marker of alcohol use disorder-and its relationship to alcohol use severity over time. The aims of this study were to test whether (1) adolescents and adults differ in social alcohol cue reactivity in the nucleus accumbens, anterior cingulate cortex, and right medial prefrontal cortex (mPFC), and (2) age moderates the relationship between social alcohol cue reactivity and social attunement, measures of drinking at baseline, and changes in drinking over time. A sample of male adolescents (16-18 years) and adults (29-35 years) completed an fMRI social alcohol cue-exposure task at baseline and an online follow-up two to three years later. No main effects of age or drinking measures were observed in social alcohol cue reactivity. However, age significantly moderated associations of social alcohol cue reactivity in the mPFC and additional regions from exploratory whole-brain analyses with SA, with a positive association in adolescents and negative association in adults. Significant age interactions emerged only for SA in predicting drinking over time. Adolescents with higher SA scores escalated drinking, while adults with higher SA scores reduced drinking. These findings warrant further research on SA as a risk and protective factor and suggest that social processes influence cue reactivity differentially in male adolescents and adults.</p

From everyday life to measurable problematic smartphone use:The development and validation of the Smartphone Use Problems Identification Questionnaire (SUPIQ)

BACKGROUND AND AIMS: Problematic smartphone use (PSU) has gained attention, but its definition remains debated. This study aimed to develop and validate a new scale measuring PSU-the Smartphone Use Problems Identification Questionnaire (SUPIQ).METHODS: Using two separate samples, a university community sample (N = 292) and a general population sample (N = 397), we investigated: (1) the construct validity of the SUPIQ through exploratory and confirmatory factor analyses; (2) the convergent validity of the SUPIQ with correlation analyses and the visualized partial correlation network analyses; (3) the psychometric equivalence of the SUPIQ across two samples through multigroup confirmatory factor analyses; (4) the explanatory power of the SUPIQ over the Short Version of Smartphone Addiction Scale (SAS-SV) with hierarchical multiple regressions.RESULTS: The results showed that the SUPIQ included 26 items and 7 factors (i.e., Craving, Coping, Habitual Use, Social Conflicts, Risky Use, Withdrawal, and Tolerance), with good construct and convergent validity. The configural measurement invariance across samples was established. The SUPIQ also explained more variances in mental health problems than the SAS-SV.DISCUSSION AND CONCLUSIONS: The findings suggest that the SUPIQ shows promise as a tool for assessing PSU. Further research is needed to enhance and refine the SUPIQ as well as to investigate its clinical utility.</p

Implicit Associations and Explicit Expectancies toward Cannabis in Heavy Cannabis Users and Controls

Cognitive biases, including implicit memory associations are thought to play an important role in the development of addictive behaviors. The aim of the present study was to investigate implicit affective memory associations in heavy cannabis users. Implicit positive-arousal, sedation, and negative associations toward cannabis were measured with three Single Category Implicit Association Tests (SC-IAT’s) and compared between 59 heavy cannabis users and 89 controls. Moreover, we investigated the relationship between these implicit affective associations and explicit expectancies, subjective craving, cannabis use, and cannabis related problems. Results show that heavy cannabis users had stronger implicit positive-arousal associations but weaker implicit negative associations toward cannabis compared to controls. Moreover, heavy cannabis users had stronger sedation but weaker negative explicit expectancies toward cannabis compared to controls. Within heavy cannabis users, more cannabis use was associated with stronger implicit negative associations whereas more cannabis use related problems was associated with stronger explicit negative expectancies, decreasing the overall difference on negative associations between cannabis users and controls. No other associations were observed between implicit associations, explicit expectancies, measures of cannabis use, cannabis use related problems, or subjective craving. These findings indicate that, in contrast to other substances of abuse like alcohol and tobacco, the relationship between implicit associations and cannabis use appears to be weak in heavy cannabis users

Associations between hair-derived cannabinoid levels, self-reported use, and cannabis-related problems

Rationale As cannabis potency and cannabis use are increasing in newly legalized markets, it is increasingly important to measure and examine the effects of cannabinoid exposure. Objectives The current study aims to assess how hair-derived cannabinoid concentrations – offering insight into three-month cumulative exposure – are associated with common self-report measures of cannabis use and cannabis use-related problems. Methods 74 near-daily dependent cannabis users self-reported their quantity of cannabis use, cannabis use-related problems, and estimated cannabis potency. Hair samples were provided to quantify Δ9-THC, CBD, and CBN using LC–MS/MS and THC-consumption was verified by analyzing THC-COOH in hair using GC–MS/MS. Results Cannabinoids were detectable in 95.95% of the hair samples from individuals who tested positive on a urine screen for cannabis. Δ9-THC concentrations were positively associated with measures of self-reported potency (relative potency, potency category, and perceived ‘high’), but Δ9-THC, CBD, CBN concentrations and THC/CBD ratio were not associated with self-reported quantity of use. Self-reported potency, but not hair-derived concentrations, were associated with withdrawal and craving. Self-reported quantity of cannabis use, but not cannabinoid concentrations, were associated with cannabis use-related problems. Conclusions The use of hair-derived cannabinoid quantification is supported for detecting cannabis use in near-daily users, but the lack of associations between hair-derived cannabinoid concentrations and self-report measures of use does not support the use of hair analyses alone for quantification of cannabinoid exposure. Further research comparing hair-derived cannabinoid concentrations with other biological matrices (e.g. plasma) and self-report is necessary to further evaluate the validity of hair analyses for this purpose