Effects of Weight Loss Among Metabolically Healthy Obese Men and Women

OBJECTIVE — Weight loss among metabolically healthy obese (MHO) individuals may be unnecessary or result in elevated cardio-metabolic risk. We studied the effects of exercise- or diet-induced weight loss on cardio-metabolic risk among MHO and metabolically abnormal obese (MAO) adults. RESEARCH DESIGN AND METHODS — Participants were 63 MHO and 43 MAO adults who took part in 3 to 6 months of exercise- or diet-induced weight loss intervention. Changes in anthropometry, adipose tissue distribution, and cardio-metabolic risk factors were assessed. RESULTS — Body weight, waist circumference, and total abdominal and visceral adipose tissue were reduced in all subjects (P 0.05). Improvements in insulin sensitivity were observed in MHO and MAO men and women (P 0.05), but were greater in the MAO individuals (P 0.05). Fasting insulin was the only other cardio-metabolic improvement among MHO individ-uals (P 0.05). CONCLUSIONS — Lifestyle-induced weight loss among MHO subjects is associated with a reduction in total and abdominal obesity and improvement in selected cardio-metabolic risk factors. Diabetes Care 33:1957–1959, 2010 W eight loss among metabolicallyhealthy obese (MHO) individu-als characterized by low cardio-metabolic risk and low prospective risk of type 2 diabetes and cardiovascular disease may be unnecessary and paradoxically may actually increase health risk (1,2). That weight reduction may be contraindi-cated for MHO individuals is at odds with the standing recommendation from lead-ing health authorities that weight loss be the primary treatment strategy for all obese patients, regardless of cardio-metabolic status (3). We sought to inves-tigate the effects of exercise- and diet-induced weight reduction on cardio-metabolic risk factors among MHO and metabolically abnormal obese (MAO) adults

Perturbations of moving membranes in AdS_7

We study the stability of uniformly moving membrane-like objects in seven dimensional Anti-de Sitter space. This is approached by a linear perturbation analysis and a search for growing modes. We examine both analytic and numerical configurations previously found in [1].Comment: 20 pages, 6 figure

Method for estimating rockfall failure probability using photogrammetry

Passageways cut through rock might be subjected to rockfalls. If a falling rock reaches the road area, the consequences can be disastrous. The traditional rockfall risk assessment method and risk mitigation are based on on-site investigations performed by a geologist or a rock engineer. The parameters resulting from the investigation, such as discontinuities, orientations and spacings, potential rockfall initiation locations, slope geometry, and ditch profile, are either measured or estimated. We propose a photogrammetry-based method for estimating the probability of failure for rockfall. Several photographs of the rock-cut are taken, and a 3D geometry is computed using photogrammetry. This model already allows remote visual inspection of the site. The information about joint planes can be discovered semiautomatically from the point cloud. Next, the probability of rockfall reaching the road area is computed using probabilistic kinematic analysis on the geometry extracted using photogrammetry. The results can be used to define the rockfall probability for each rock-cut. Furthermore, the results can be used to determine the appropriate rockfall risk mitigation actions for each rock-cut

Moving Defects in AdS/CFT

We study defects of various dimensions moving through Anti-de Sitter space. Using the AdS/CFT correspondence this allows us to probe aspects of the dual quantum field theory. We focus on the energy loss experienced by these defects as they move through the CFT plasma. We find that the behavior of these physical quantities is governed by induced world-volume horizons. We identify world-volume analogs for several gravitational phenomena including black holes, the Hawking-Page phase transition and expanding cosmological horizons.Comment: 24 pages, 7 figures. Version 2 contains two added reference

Background risk of breast cancer and the association between physical activity and mammographic density

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/ by/4.0

Holographic Brownian Motion in Magnetic Environments

Using the gauge/gravity correspondence, we study the dynamics of a heavy quark in two strongly-coupled systems at finite temperature: Super-Yang-Mills in the presence of a magnetic field and non-commutative Super-Yang-Mills. In the former, our results agree qualitatively with the expected behavior from weakly-coupled theories. In the latter, we propose a Langevin equation that accounts for the effects of non-commutativity and we find new interesting features. The equation resembles the structure of Brownian motion in the presence of a magnetic field and implies that the fluctuations along non-commutative directions are correlated. Moreover, our results show that the viscosity is smaller than the commutative case and that the diffusion properties of the quark are unaffected by non-commutativity. Finally, we compute the random force autocorrelator and verify that the fluctuation-dissipation theorem holds in the presence of non-commutativity.Comment: 34 pages. v2: typos corrected. v3: title and abstract slightly modified in order to better reflect the contents of the paper; footnote 3 and one reference were also added; version accepted for publication in JHE

POLETOWN NEIGHBORHOOD COUNCIL, a voluntary unincorporated association

Corporation as a site for construction of an assembly plant. The plaintiffs, a neighborhood association and several individual residents of the affected area, brought suit in Wayne Circuit Court to challenge the project on a number of grounds, not all of which have been argued to this Court. Defendants' motions for summary judgment were denied pending trial on a single question of fact: whether, under 1980 PA 87; M.C.L. § 213.51 et seq ; M.S.A. § 8.265(1) et seq, the city abused its discretion in determining that condemnation of plaintiffs' property was necessary to complete the project

Post-Streptococcal Antibodies Are Associated with Metabolic Syndrome in a Population-Based Cohort

Background: Streptococcal infections are known to trigger autoimmune disorders, affecting millions worldwide. Recently, we found an association between post-streptococcal autoantibodies against Protein Disulphide Isomerase (PDI), an enzyme involved in insulin degradation and insulin resistance. This led us to evaluate associations between post-streptococcal antibodies and metabolic syndrome, as defined by the updated National Cholesterol Education Program definition, 2005. Methods and Findings: Metabolic data (HDL, triglycerides, fasting glucose, blood pressure, waist circumference, BMI, smoking), post-streptococcal antibodies (anti-Streptolysin O (ASO) and anti-PDI), and C-reactive protein (CRP, as a general inflammatory marker), were assessed in 1156 participants of the Wisconsin Sleep Cohort Study. Anti-PDI antibodies were found in 308 participants (26.6%), ASO$100 in 258 (22.3%), and 482 (41.7%) met diagnostic criteria for metabolic syndrome. Anti-PDI antibodies but not ASO were significantly associated with metabolic syndrome [n = 1156, OR 1.463 (95 % CI 1.114, 1.920), p = 0.0062; adjusted for age, gender, education, smoking]. Importantly, the anti-PDI- metabolic syndrome association remained significant after adjusting for CRP and fasting insulin. Conclusions: Post-streptococcal anti-PDI antibodies are associated with metabolic syndrome regardless of fasting insulin and CRP levels. Whereas these data are in line with a growing body of evidence linking infections, immunity an