Association between umbilical cord glucocorticoids and blood pressure at age 3 years

<p>Abstract</p> <p>Background</p> <p>Animal data show that decreased activity of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which potently inactivates glucocorticoids (e.g. cortisol) to inert forms (cortisone), allows increased access of maternal glucocorticoids to the fetus and 'programs' hypertension. Data in humans are limited. We examined in humans the association between venous umbilical cord blood glucocorticoids, a potential marker for placental 11β-HSD2 enzyme activity, and blood pressure at age 3 years.</p> <p>Methods</p> <p>Among 286 newborns in Project Viva, a prospective pre-birth cohort study based in eastern Massachusetts, we measured cortisol (<it>F</it>) and cortisone (<it>E</it>) in venous cord blood and used the ratio of <it>F/E </it>as a marker for placental 11β-HSD2 activity. We measured blood pressure (BP) when the offspring reached age 3 years. Using mixed effects regression models to control for BP measurement conditions, maternal and child characteristics, we examined the association between the <it>F/E </it>ratio and child BP.</p> <p>Results</p> <p>At age 3 years, each unit increase in the <it>F/E </it>ratio was associated with a 1.6 mm Hg increase in systolic BP (95% CI 0.0 to 3.1). The <it>F/E </it>ratio was not associated with diastolic blood pressure or birth weight for gestational age <it>z</it>-score.</p> <p>Conclusion</p> <p>A higher <it>F/E </it>ratio in umbilical venous cord blood, likely reflecting reduced placental 11β-HSD2 activity, was associated with higher systolic blood pressure at age 3 years. Our data suggest that increased fetal exposure to active maternal glucocorticoids may program later systolic blood pressure.</p

Helplessness in Early Childhood: Prediction of Symptoms Associated With Depression and Negative Self-Worth

We tested the hypothesis that the early emergence of helplessness has negative implications for later adjustment, particularly risk for depression and negative self-worth. A composite measure of helplessness was derived from kindergartners’ (N 112; 55 boys and 57 girls; 10 non-White) responses to a challenging, developmentally appropriate task. Kindergartners’ self-perceptions were also assessed in order to control for initial tendencies to report negatively about themselves. Five years later, selfreported depressive symptoms, feelings of self-worth, and teachers’ ratings of depression were obtained. As predicted, helplessness in kindergarten predicted more depressive symptoms, as reported by children and their teachers, and more negative feelings of worth. Mechanisms underlying helplessness and implications for early intervention to reduce risk for depression are discussed

The Relationship between Anger Rumination and Aggression in Typically Developing Children and High-Risk Adolescents

This paper examines anger rumination as a risk factor of aggression in typically developing children and high-risk adolescents. Study 1 developed and evaluated the psychometric properties of a self-report measure of children\u27s anger rumination (Children\u27s Anger Rumination Scale; CARS) and its association with teacher- and peer-rated overt and relational aggression in school-aged children (n = 254, M age = 10.62). Findings offered support for the reliability and validity of the CARS as well as support for the hypothesis that children who ruminate to anger exhibit elevated levels of overt and relational aggression. Study 2 examined concurrent and prospective relationships between anger rumination and aggression and the moderating effects of trait anger in a sample of male juvenile offenders (n = 119, M age = 16.74). Latent growth curve analyses revealed that the interaction between trait anger and anger rumination predicted initial levels of aggression (i.e., intercept) and changes in aggression over time (i.e., slope). Juvenile offenders who were high in trait anger and ruminated in response to anger exhibited the highest initial levels of aggression. Contrary to our hypothesis, this group did not exhibit greater increases in aggression over time relative to others, but instead they had stably high levels of aggression at each time point. These findings suggest that cognitive-behavioral treatment strategies for aggression may be improved by educating youths about the contributory role of anger rumination in the development of aggression and providing them with adaptive alternatives to coping with feelings of anger