Analysis of whisker-toughened ceramic components: A design engineer's viewpoint

The use of ceramics components in gas turbines, cutting tools, and heat exchangers has been limited by the relatively low flaw tolerance of monolithic ceramics. The development of whisker toughened ceramic composites offers the potential for considerable improvement in fracture toughness as well as strength. However, the variability of strength is still too high for the application of deterministic design approaches. Several phenomenological reliability theories proposed for this material system are reviewed and the development is reported of a public domain computer algorithm. This algorithm, when coupled with a general purpose finite element program, predicts the fast fracture reliability of a structural component under multiaxial loading conditions

Noninteractive Macroscopic Reliability Model for Ceramic Matrix Composites With Orthotropic Material Symmetry

A macroscopic noninteractive reliability model for ceramic matrix composites is presented. The model is multiaxial and applicable to composites that can be characterized as orthotropic. Tensorial invariant theory is used to create an integrity basis with invariants that correspond to physical mechanisms related to fracture. This integrity basis is then used to construct a failure funciton per unit volume (or area) of material. It is assumed that the overall strength of the composite is governed by weakest link theory. This leads to a Weibull type model similar in nature to the principle of independent action (PIA) model for isotropic monolithic ceramics. An experimental program to obtain model parameters is briefly discussed. In addition, qualitative features of the model are illustrated by presenting reliability surfaces for various model parameters

Using Convolutional Neural Networks to identify Gravitational Lenses in Astronomical images

The Euclid telescope, due for launch in 2021, will perform an imaging and slitless spectroscopy survey over half the sky, to map baryon wiggles and weak lensing. During the survey Euclid is expected to resolve 100,000 strong gravitational lens systems. This is ideal to find rare lens configurations, provided they can be identified reliably and on a reasonable timescale. For this reason we have developed a Convolutional Neural Network (CNN) that can be used to identify images containing lensing systems. CNNs have already been used for image and digit classification as well as being used in astronomy for star-galaxy classification. Here our CNN is trained and tested on Euclid-like and KiDS-like simulations from the Euclid Strong Lensing Group, successfully classifying 77% of lenses, with an area under the ROC curve of up to 0.96. Our CNN also attempts to classify the lenses in COSMOS HST F814W-band images. After convolution to the Euclid resolution, we find we can recover most systems that are identifiable by eye. The Python code is available on Github

A latest Cretaceous to earliest Paleogene dinoflagellate cyst zonation of Antarctica, and implications for phytoprovincialism in the high southern latitudes

The thickest uppermost Cretaceous to lowermost Paleogene (Maastrichtian to Danian) sedimentary succession in the world is exposed on southern Seymour Island (65° South) in the James Ross Basin, Antarctic Peninsula. This fossiliferous shallow marine sequence, which spans the Cretaceous–Paleogene boundary, has allowed a high-resolution analysis of well-preserved marine palynomorphs. Previous correlation of Cretaceous–Paleogene marine palynomorph assemblages in the south polar region relied on dinoflagellate cyst biozonations from New Zealand and southern Australia. The age model of the southern Seymour Island succession is refined and placed within the stratigraphical context of the mid to high southern palaeolatitudes. Quantitative palynological analysis of a new 1102 m continuous stratigraphical section comprising the uppermost Snow Hill Island Formation and the López de Bertodano Formation (Marambio Group) across southern Seymour Island was undertaken. We propose the first formal late Maastrichtian to early Danian dinoflagellate cyst zonation scheme for the Antarctic based on this exceptional succession. Two new late Maastrichtian zones, including three subzones, and one new early Danian zone are defined. The oldest beds correlate well with the late Maastrichtian of New Zealand. In a wider context, a new South Polar Province based on Maastrichtian to Danian dinoflagellate cysts is proposed, which excludes most southern South American marine palynofloras. This interpretation is supported by models of ocean currents around Antarctica and implies an unrestricted oceanic connection across Antarctica between southern South America and the Tasman Sea

A Tailored Systems Engineering Framework for Science and Technology Projects

As government and industry becomes subject to a wider range of technology initiatives, science and technology (S&T) research project leadership recognizes the need to incorporate more systems engineering (SE) rigor into their projects. The objective of this research is to develop a tailorable systems engineering framework for S&T project planning, execution, assessment and transition. The key deliverable is an Excel-based tool instantiating the SE framework for a wide range of S&T projects in technology development organizations. It includes a report with tailored methods based on programmatic discriminants. To develop this framework, a comprehensive understanding of SE principles is applied to several case studies across government and supporting industry-sponsored S&T activities. This research followed a six-step approach: (1) Literature Review; (2) Formulate Taxonomy; (3) Prepare Data Gathering Approach; (4) Review Case Studies; (5) Develop Tailorable SE Framework for Technology Development and Transition; and (6) Validate Framework.The framework allows S&T project leaders and engineers to customize a recommended set of SE processes, methods and tools for their specific project type, size, maturity, budget, and integration level. Recommendations for SE methods are made at a summary level, with additional details available for desired activities. References to established SE documentation is also included for further investigation of appropriate SE techniques

A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry

A novel bunyavirus was recently found to cause severe febrile illness with high mortality in agricultural regions of China, Japan, and South Korea. This virus, named severe fever with thrombocytopenia syndrome virus (SFTSV), represents a new group within the Phlebovirus genus of the Bunyaviridae. Little is known about the viral entry requirements beyond showing dependence on dynamin and endosomal acidification. A haploid forward genetic screen was performed to identify host cell requirements for SFTSV entry. The screen identified dependence on glucosylceramide synthase (ugcg), the enzyme responsible for initiating de novo glycosphingolipid biosynthesis. Genetic and pharmacological approaches confirmed that UGCG expression and enzymatic activity were required for efficient SFTSV entry. Furthermore, inhibition of UGCG affected a post-internalization stage of SFTSV entry, leading to the accumulation of virus particles in enlarged cytoplasmic structures, suggesting impaired trafficking and/or fusion of viral and host membranes. These findings specify a role for glucosylceramide in SFTSV entry and provide a novel target for antiviral therapies

Analysis of Whisker-Toughened Ceramic Components -- A Design Engineer\u27s Viewpoint

The use of ceramics components in gas turbines, cutting tools, and heat exchangers has been limited by the relatively low flaw tolerance of monolithic ceramics. The development of whisker-toughened ceramic composites offers the potential for considerable improvement in fracture toughness as well as strength. However, the variability of strength is still too high for the application of deterministic design approaches. This report reviews several phenomenological reliability theories proposed for this material system, and reports on the development of a public domain computer algorithm. This algorithm, when coupled with a general-purpose finite element program, predicts the fast fracture reliability of a structural component under multiaxial loading conditions

What oncologists tell patients about survival benefits of palliative chemotherapy and implications for informed consent: qualitative study

Objective To examine how much oncologists tell patients about the survival benefit of palliative chemotherapy during consultations at which decisions about treatment are made