Impairment of LTD and cerebellar learning by Purkinje cell–specific ablation of cGMP-dependent protein kinase I

The molecular basis for cerebellar plasticity and motor learning remains controversial. Cerebellar Purkinje cells (PCs) contain a high concentration of cGMP-dependent protein kinase type I (cGKI). To investigate the function of cGKI in long-term depression (LTD) and cerebellar learning, we have generated conditional knockout mice lacking cGKI selectively in PCs. These cGKI mutants had a normal cerebellar morphology and intact synaptic calcium signaling, but strongly reduced LTD. Interestingly, no defects in general behavior and motor performance could be detected in the LTD-deficient mice, but the mutants exhibited an impaired adaptation of the vestibulo-ocular reflex (VOR). These results indicate that cGKI in PCs is dispensable for general motor coordination, but that it is required for cerebellar LTD and specific forms of motor learning, namely the adaptation of the VOR

Kesiapan Petugas Puskesmas dalam Penanggulangan Infeksi Menular Seksual dan Hiv/aids pada Pelayanan Antenatal

Background: Prevalence HIV/AIDS among housewife has been increasing which was notice by higher cases of HIVpositive babies. An effective intervention effort in the health sector is to accelerate the decreasing of Maternal Mortality Rate (MMR) through integrated approach of reproductive health care and STD HIV/AIDS. One of reproductive health services was to prevention and treatment of STD-HIV/AIDS. When this program was integrated with antenatal care it will prevents transmission of HIV from mother to child. The program called Prevention Mother To Child Transmission or PMTCT. Recently in Indonesia program antenatal care has not yet optimally integrated with STD-HIV/AIDS service. The objectiive of this study was to know how far preparedness of health center personnel in prevention transmission of STD, HIV/AIDS integrated with antenatal care. Methods: This study was exploration research. Respondents of this study were personals of public health center that have task related to antenal care and prevention program of STD, HIV/AIDS. Locations of study were Surabaya Malang Blitar Tulungagung, Semarang, Surakarta, Denpasar and Batam. Dara collection was done by interviewed and Focus Group Discussion. Results: The result of the study revealed the unprepared-ness of PHC personnel in term of knowledge about reproductive health and skill in universal precaution practice in integrated program of prevention STD, HIV/AIDS and antenatal care. Lack of facilities and its supporting system including the laboratory equipment and reagents also make activities of this integrated program being obstacle. Health service program still conducted fragmented because there was no standard operational procedure (SOP) of integrated program of STD, HIV/AIDS prevention and antenatal care. It was suggested to conduct a comprehensive program of reproductive health by increasing health personnel knowledge and skill with training; arrange SOP of integrated program of STD, HIV/AIDS prevention and antenatal care. It also needs to complete the facility with laboratory equipment i.e. rapid test and drugs to support this integrated program

Psycholog:innen als Sachverständige für Gutachten zur Schuldfähigkeit und Massnahmenindikation im Erwachsenenstrafrecht

Nach aktueller Rechtsprechung ist die Begutachtung der Schuldfähigkeit und Massnahmenindikation Personen mit Facharzttitel für Psychiatrie und Psychotherapie vorbehalten. Der damit verbundene Ausschluss von Psycholog:innen ist angesichts der Entwicklungen in den letzten zehn Jahren nicht gerechtfertigt. Die Autor:innen zeigen auf, unter welchen Weiterbildungsbedingungen Psycholog:innen als Sachverständige geeignet sind. -- Selon la jurisprudence actuelle, seuls des personnes détenant un titre de médecin spécialiste en psychiatrie et psychothérapie sont autorisés à réaliser les expertises en matière de responsabilité et d'indication de mesures. L'exclusion des psychologues, qui en découle, ne se justifie pas au vu des évolutions de ces dix dernières années. Les auteur·e·s démontrent les formations continues nécessaires pour que des psychologues soient apte à effectuer de telles expertises

Mitochondrial respiratory states and rate

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminologyconcerning mitochondrial respiratory states and rates has become increasingly apparent. Thechemiosmotic theoryestablishes the mechanism of energy transformationandcoupling in oxidative phosphorylation. Theunifying concept of the protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial physiology and bioenergetics.We followguidelines of the International Union of Pure and Applied Chemistry(IUPAC)onterminology inphysical chemistry, extended by considerationsofopen systems and thermodynamicsof irreversible processes.Theconcept-driven constructive terminology incorporates the meaning of each quantity and alignsconcepts and symbols withthe nomenclature of classicalbioenergetics. We endeavour to provide a balanced view ofmitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.Uniform standards for evaluation of respiratory states and rates will ultimatelycontribute to reproducibility between laboratories and thussupport the development of databases of mitochondrial respiratory function in species, tissues, and cells.Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Cracks, microcracks and fracture in polymer structures: Formation, detection, autonomic repair

The first author would like to acknowledge the financial support from the European Union under the FP7 COFUND Marie Curie Action. N.M.P. is supported by the European Research Council (ERC StG Ideas 2011 n. 279985 BIHSNAM, ERC PoC 2015 n. 693670 SILKENE), and by the EU under the FET Graphene Flagship (WP 14 “Polymer nano-composites” n. 696656)