Prasugrel versus ticagrelor in patients with Acute Coronary syndrome treated with percutaneous coronary intervention

Background: No association studies for the efficacy and safety of ticagrelor vs. prasugrel have been published in India. Aim of the study was to compare the safety and efficacy of Prasugrel versus Ticagrelor in Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention.Methods: This retrospective study was designed to compare the efficacy and safety of prasugrel and ticagrelor in acute coronary syndromes (ACS) with percutaneous coronary intervention (PCI). A total of 480 patients were studied who had been prescribed either prasugrel or ticagrelor during PCI. Primary end-point was defined as death, re-infarction, urgent target vessel revascularization, serious bleeding requiring transfusion.Results: Primary endpoint was different between the groups receiving prasugrel and ticagrelor (1.2% and 4.0%, respectively; OR (95% CI) 0.38 (0.098; 1.43); P=0.065). Difference was found in the need for urgenttarget vessel revascularization which was significantly lower in the prasugrel group.Rest of the parameters were almost similar with no significant difference.Conclusions: This study comparing prasugrel and ticagrelor shows that Prasugrel is more effective than Ticagrelor in lowering ischemic events in the acute coronary syndromes treated with PCI strategy, especially incidence of stent thrombosis. These observations need further analysis and follow-up

Estimating fast and slow reacting components in surface water and groundwater using a two-reactant model

Maintaining residual chlorine levels in a water distribution network is a challenging task, especially in the context of developing countries where water is usually supplied intermittently. To model chlorine decay in water distribution networks, it is very important to understand chlorine kinetics in bulk water. Recent studies have suggested that chlorine decay rate depends on initial chlorine levels and the type of organic and inorganic matter present in water, indicating that a first-order decay model is unable to accurately predict chlorine decay in bulk water. In this study, we employed the two-reactant (2R) model to estimate the fast and slow reacting components in surface water and groundwater. We carried out a bench-scale test for surface water and groundwater at initial chlorine levels of 1, 2, and 5 mg L−1. We used decay data sets to estimate optimal parameter values for both surface water and groundwater. After calibration, the 2R model was validated with two decay data sets with varying initial chlorine concentrations (ICCs). This study arrived at three important findings. (a) We found that the ratio of slow to fast reacting components in groundwater was 30 times greater than that of the surface water. This observation supports the existing literature which indicates the presence of high levels of slow reacting fractions (manganese and aromatic hydrocarbons) in groundwater. (b) Both for surface water and groundwater, we obtained good model prediction, explaining 97 % of the variance in data for all cases. The mean square error obtained for the decay data sets was close to the instrument error, indicating the feasibility of the 2R model for chlorine prediction in both types of water. (c) In the case of deep groundwater, for high ICC levels (> 2 mg L−1), the first-order model can accurately predict chlorine decay in bulk water

Prasugrel versus ticagrelor in patients with Acute Coronary syndrome treated with percutaneous coronary intervention

Background: No association studies for the efficacy and safety of ticagrelor vs. prasugrel have been published in India. Aim of the study was to compare the safety and efficacy of Prasugrel versus Ticagrelor in Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention.Methods: This retrospective study was designed to compare the efficacy and safety of prasugrel and ticagrelor in acute coronary syndromes (ACS) with percutaneous coronary intervention (PCI). A total of 480 patients were studied who had been prescribed either prasugrel or ticagrelor during PCI. Primary end-point was defined as death, re-infarction, urgent target vessel revascularization, serious bleeding requiring transfusion.Results: Primary endpoint was different between the groups receiving prasugrel and ticagrelor (1.2% and 4.0%, respectively; OR (95% CI) 0.38 (0.098; 1.43); P=0.065). Difference was found in the need for urgenttarget vessel revascularization which was significantly lower in the prasugrel group.Rest of the parameters were almost similar with no significant difference.Conclusions: This study comparing prasugrel and ticagrelor shows that Prasugrel is more effective than Ticagrelor in lowering ischemic events in the acute coronary syndromes treated with PCI strategy, especially incidence of stent thrombosis. These observations need further analysis and follow-up

Growth Attributes and Their Interaction in Toria (Brassica campestris) as Influenced by Various Levels of Phosphorus and Sulphur in Mid Hill Zone of Himachal Pradesh

A field experiment was carried out at Research Farm Kakli, Eternal University, Baru Sahib (H.P.) during Rabi season of 2021-22 to study the “Growth Attributes and their Interaction in Toria (Brassica campestris) as Influenced by Various Levels of Phosphorus and Sulphur in Mid Hill Zone of Himachal Pradesh.” The trial comprised of two factors (phosphorus and sulphur) which prepared twelve treatment combinations and positioned out in factorial randomized block design (FRBD) and replicated thrice to attain the unvarying and unbiased results. The texture of soil was sandy loam with pH 7.12.The twelve treatment combinations comprising four phosphorus levels (15-30-45-60 kg P2O5 /ha) and three levels of sulphur (20-30-40 kg S /ha). It was ascertained that significantly higher plant height, number of leaves /plant, number of branches /plant and dry weight /plant, were reported under treatment P4 i.e. 60 kg P2O5 /ha. Amongst the several levels of sulphur, significantly higher growth attributes i.e. plant height, number of leaves /plant, number of branches /plant and dry weight /plant were reported under treatment S3 i.e. 40 kg S /ha

A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern.

The emergence of new variants of SARS-CoV-2 necessitates unremitting efforts to discover novel therapeutic monoclonal antibodies (mAbs). Here, we report an extremely potent mAb named P4A2 that can neutralize all the circulating variants of concern (VOCs) with high efficiency, including the highly transmissible Omicron. The crystal structure of the P4A2 Fab:RBD complex revealed that the residues of the RBD that interact with P4A2 are a part of the ACE2-receptor-binding motif and are not mutated in any of the VOCs. The pan coronavirus pseudotyped neutralization assay confirmed that the P4A2 mAb is specific for SARS-CoV-2 and its VOCs. Passive administration of P4A2 to K18-hACE2 transgenic mice conferred protection, both prophylactically and therapeutically, against challenge with VOCs. Overall, our data shows that, the P4A2 mAb has immense therapeutic potential to neutralize the current circulating VOCs. Due to the overlap between the P4A2 epitope and ACE2 binding site on spike-RBD, P4A2 may also be highly effective against a number of future variants

Abstracts of AICTE Sponsored International Conference on Post-COVID Symptoms and Complications in Health

This book presents the selected abstracts of the International Conference on Post-COVID Symptoms and Complications in Health, hosted from the 28th to 29th of April 2022 in virtual mode by the LR Institute of Pharmacy, Solan (H.P.)-173223 in Collaboration with AICTE, New Delhi. This conference focuses on the implications of long-term symptoms on public health, ways to mitigate these complications, improve understanding of the disease process in COVID-19 patients, use of computational methods and artificial intelligence in predicting complications, and the role of various drug delivery systems in combating the complications. Conference Title:  International Conference on Post-COVID Symptoms and Complications in HealthConference Sponsor: AICTE, New Delhi.Conference Date: 28-29 April 2022Conference Location: OnlineConference Organizer: LR Institute of Pharmacy, Solan (H.P.)-173223

Abstracts of AICTE Sponsored International Conference on Post-COVID Symptoms and Complications in Health

This book presents the selected abstracts of the International Conference on Post-COVID Symptoms and Complications in Health, hosted from the 28th to 29th of April 2022 in virtual mode by the LR Institute of Pharmacy, Solan (H.P.)-173223 in Collaboration with AICTE, New Delhi. This conference focuses on the implications of long-term symptoms on public health, ways to mitigate these complications, improve understanding of the disease process in COVID-19 patients, use of computational methods and artificial intelligence in predicting complications, and the role of various drug delivery systems in combating the complications. Conference Title:  International Conference on Post-COVID Symptoms and Complications in HealthConference Sponsor: AICTE, New Delhi.Conference Date: 28-29 April 2022Conference Location: OnlineConference Organizer: LR Institute of Pharmacy, Solan (H.P.)-173223

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual