Abnormal lipid metabolism is associated with angiogenic and anti angiogenic factor imbalance in PIH women

Background: Preeclampsia is a major cause of maternal and fetal/neonatal mortality and morbidity even in developed countries. Despite of extensive research, the etiology and pathogenesis of preeclampsia are not completely understood. Evidence shows that imbalance between angiogenic and antiangiogenic factor plays a pivotal role in the genesis of endothelial dysfunction which is considered as a hall mark in the development of multisystem disorder in pre-eclampsia and eclampsia. Abnormal lipid metabolism is a known causative factor for endothelial dysfunction. This study has been designed to determine the association between abnormal lipids and angiogenic, anti angiogenic balance in PIH (PE and E) women.Methods: Study group consisted of Normotensive pregnant women (N) preeclamptic women (PE) and eclamptic women (E) with 100 subjects in each group in the 3rd trimester of pregnancy. They were investigated for lipid profile and apolipoproteins, MDA, FRAP, TNF-α, sFlt-1, VEGF, PlGF, NO. Statistical analysis was done using ANOVA and pearson correlation analysis.Results: When compared to controls TC, TGL, VLDL, LDL, apoB, MDA, TNF-α, sFlt-1 levels were found to be significantly high and HDL, apoA, FRAP, VEGF, PIGF, and NO levels were significantly low in PE, E group.  Eclamptic women showed a significantly high level of MDA, TNF-α, sFlt-1and low levels of FRAP, VEGF, PIGF, NO when compared to PE group.Conclusions: In PIH women, abnormal lipid metabolism is associated with angiogenic and antiangiogenic imbalance

ApoB/ApoA-1 ratio and nitric oxide levels in pregnancy induced hypertensive women

Background: Pregnancy induced hypertension is considered as the major cause of maternal and perinatal mortality. Even though occurrence of PIH is due to abnormal placentation, endothelial dysfunction plays a pivotal role in the genesis of the multisystem disorder that develops in pre eclampsia and eclampsia. Various studies have proved that hyperlipidemia is one of the major causes of endothelial dysfunction. Since ApoB/apoA-I ratio is a dyslipidemic indicator, the study was designed to determine ApoB/ApoA-I in PIH women and to analyse whether this ratio can be correlated with ED in PIH women.Methods: A cross-sectional analytical study involved normotensive, preeclamptic and eclamptic pregnant women with hundred subjects in each group. They were investigated for serum lipid profile, ApoA, ApoB, NO, MDA, FRAP in the 3rd trimester of pregnancy.Results: The SBP & DBP were significantly high between 3 groups. The mean plasma TC, TGL, VLDL, LDL, MDA, ApoB levels, ApoB/ApoA-I were significantly high & HDL, ApoA-I, NO, FRAP levels were significantly low between 3 groups. The ApoB/ApoA-I was positively correlated with TC, TGL, VLDL, LDL, malondialdehyde and negatively correlated with HDL, FRAP & NO.Conclusions: Our results indicate that women with PE & E exhibit markedly elevated concentrations of TGL-rich lipoproteins. The negative correlation between ApoB/ApoA-I with NO indicates that the hyperlipidemia is directly related with severity of ED in PIH. So, careful monitoring of ApoB/ApoA-I along with NO might be helpful to predict the onset and progression of the disease