2008 Patent Law Decisions of the Federal Court A Review of Recent Decisions of the United States Court of Appeals for the Federal Circuit: Area Summaries

The United States Supreme Court took a slight breather from patent-law issues in 2008. After issuing three patent-law decisions in 2007 (including KSR International Co. v. Teleflex Inc.), the Court issued just one patent-law decision in 2008—Quanta Computer, Inc. v. LG Electronics, Inc. Despite the Supreme Court’s slower pace, however, the Court’s influence loomed large in the United States Court of Appeals for the Federal Circuit in 2008. In a number of cases, the Federal Circuit continued to work through the implications of the Supreme Court’s recent precedents, most notably KSR and the Supreme Court’s 2006 decision in eBay Inc. v. MercExchange, L.L.C. The Federal Circuit’s continued efforts to apply these cases in different technological and competitive settings may be setting the stage for further elaboration from the Supreme Court on the standard for obviousness and the availability of injunctive relief in patent infringement cases. The Federal Circuit also, in two en banc decisions, preemptively reevaluated some of its own precedents, considering how they measured up against older (but still binding) Supreme Court case law. In In re Bilski, the Federal Circuit considered its 35 U.S.C. § 101 patentable-subject-matter jurisprudence against previous Supreme Court decisions such as Diamond v. Diehr and Gottschalk v. Benson. And in Egyptian Goddess, Inc. v. Swisa, Inc., the Federal Circuit went back even further in the annals of Supreme Court jurisprudence and revised its own design patent case law in light of the Supreme Court’s 1871 decision in Gorham Co. v. White

2008 Patent Law Decisions of the Federal Court A Review of Recent Decisions of the United States Court of Appeals for the Federal Circuit: Area Summaries

The United States Supreme Court took a slight breather from patent-law issues in 2008. After issuing three patent-law decisions in 2007 (including KSR International Co. v. Teleflex Inc.), the Court issued just one patent-law decision in 2008—Quanta Computer, Inc. v. LG Electronics, Inc. Despite the Supreme Court’s slower pace, however, the Court’s influence loomed large in the United States Court of Appeals for the Federal Circuit in 2008. In a number of cases, the Federal Circuit continued to work through the implications of the Supreme Court’s recent precedents, most notably KSR and the Supreme Court’s 2006 decision in eBay Inc. v. MercExchange, L.L.C. The Federal Circuit’s continued efforts to apply these cases in different technological and competitive settings may be setting the stage for further elaboration from the Supreme Court on the standard for obviousness and the availability of injunctive relief in patent infringement cases. The Federal Circuit also, in two en banc decisions, preemptively reevaluated some of its own precedents, considering how they measured up against older (but still binding) Supreme Court case law. In In re Bilski, the Federal Circuit considered its 35 U.S.C. § 101 patentable-subject-matter jurisprudence against previous Supreme Court decisions such as Diamond v. Diehr and Gottschalk v. Benson. And in Egyptian Goddess, Inc. v. Swisa, Inc., the Federal Circuit went back even further in the annals of Supreme Court jurisprudence and revised its own design patent case law in light of the Supreme Court’s 1871 decision in Gorham Co. v. White

Actical Accelerometry Cut-points for Quantifying Levels of Exertion: Comparing Normal and Overweight Adults

Int J Exerc Sci 5(2) : 170-182, 2012. Weight, body fatness and ambulatory pattern all have the potential to affect accelerometer output and cause differences in output between overweight and normal-weight adults. The purpose of this study was to determine if Actical (Philips Respironics, Bend, OR) activity count cut-points for moderate and vigorous intensity exercise are different for overweight adults compared to normal-weight adults. Overweight adults with BMI \u3e25 kg/m² (n=29) and Normal-Weight adults (n=25) walked at 3.2 and 4.8 km∙h-1 and ran at 6.4 km∙h-1 on a treadmill while simultaneously wearing an Actical accelerometer and obtaining measurements of oxygen uptake. Counts per minute (counts∙min-1) were determined at 3 METS (moderate) and 6 METS (vigorous) using ROC curves. The counts∙min-1 at 3 METs was 1726 and 1923 counts∙min-1 for Overweight and Normal-Weight groups, respectively. The cut-points at 6 METs were 4117 and 4032 counts∙min-1 for Overweight and Normal-Weight groups, respectively. The differences between groups were not statistically significant (p\u3e0.73 for both). Correlations between BMI and counts∙min-1 were not significant (p\u3e0.05) at any speed for the Normal-Weight group but were significant at 3.2 and 4.8 km∙h-1 for the Overweight group. Although there appears to be some relationship between activity counts∙min-1 and BMI, the results suggest that similar cut-points may be used for normal weight and overweight adults. However, the greater variability in counts at each speed and lower ROC curve areas for overweight adults suggest that it is harder to classify the activity intensity of overweight subjects compared to normal weight subjects

A systematic review and thematic synthesis of patients' experience of medicines adherence

Background: Medicines non-adherence continues to be problematic in health care practice. After decades of research, few interventions have a robust evidence-based demonstrating their applicability to improve adherence. Phenomenology has a place within the health care research environment. Objective: To explore patients’ lived experiences of medicines adherence reported in the phenomenonologic literature. Methods: A systematic literature search was conducted to identify peer-reviewed and published phenomenological investigations in adults that aimed to investigate patients’ lived experiences of medicines adherence. Studies were appraised using the Critical Appraisal Skills Programme (CASP) Qualitative Research Tool. Thematic synthesis was conducted using a combination of manual coding and NVivo10 [QSR International, Melbourne] coding to aid data management. Results: Descriptive themes identified included i) dislike for medicines, ii) survival, iii) perceived need, including a) symptoms and side-effects and b) cost, and iv) routine. Analytic themes identified were i) identity and ii) interaction. Conclusions: This work describes adherence as a social interaction between the identity of patients and medicines, mediated by interaction with family, friends, health care professionals, the media and the medicine, itself. Health care professionals and policy makers should seek to re-locate adherence as a social phenomenon, directing the development of interventions to exploit patient interaction with wider society, such that patients ‘get to know’ their medicines, and how they can be taken, throughout the life of the patient and the prescription

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Space Launch System Booster Separation Supersonic Powered Testing with Surface and Off-Body Measurements

A wind tunnel test was run in the NASA Langley Unitary Plan Wind Tunnel simulating the separation of the two solid rocket boosters (SRB) from the core stage of the NASA Space Launch System (SLS). The test was run on a 0.9% scale model of the SLS Block 1B Cargo (27005) configuration and the SLS Block 1B Crew (28005) configuration at a Mach of 4.0. High pressure air was used to simulate plumes from the booster separation motors located at the nose and aft skirt of the two boosters. Force and moment data were taken on both SRBs and on the core stage. Schlieren still photos and video were recorded throughout testing. A set of points were acquired using Cross-correlation Doppler Global Velocimetry (CCDGV) readings to get 3 component velocity measurements between the core and the left-hand SRB. The CCDGV laser was utilized to record flow visualization in the same location, between the core and the left-hand SRB. Pressure Sensitive Paint data were taken on a separate set of runs. Computational Fluid Dynamics (CFD) runs were computed on a subset of the wind tunnel data points for comparison. A combination of the force/moment, CCDGV and Pressure Sensitive Paint (PSP) data (as well as schlieren images) at the CFD-specified test conditions will be used te the CFD simulations that will be used to build an SLS booster separation database flight conditions

Verification Testing To Confirm VO2max Attainment in Inactive Women With Obesity

International Journal of Exercise Science 13(4): 1448-1458, 2020. Incidence of obesity is increasing worldwide which is deleterious to health due to its association with increased risk of cardiovascular disease, diabetes, and some cancers. Completion of regular physical activity in individuals with obesity increases maximal oxygen uptake (VO2max). However, whether individuals with obesity can exhibit ‘true’ VO2max is unresolved. This study examined efficacy of verification testing (VER) to identify ‘true’ VO2max in 17 inactive women with obesity (age, body fat, and VO2max = 37 ± 10 yr, 48.7 ± 3.5 %, and 19.4 ± 3.0 mL/kg/min, respectively). They performed ramp exercise (RAMP) to volitional fatigue followed by VER at 105 percent peak power output (%PPO) at baseline and after 3 and 6 wk of high intensity interval training. Results showed no difference in ramp and verification-derived VO2max (1.99 ± 0.37 L/min vs. 1.98 ± 0.32 L/min, 2.00 ± 0.40 L/min vs. 2.04 ± 0.38 L/min, and 2.08 ± 0.34 L/min vs. 2.08 ± 0.32 L/min at 0, 3 and 6 wk of training), although in 40 % of VER tests, VO2max was greater than the RAMP value. Overall, verification testing may be adopted as an additional approach to confirm ‘true’ VO2max attainment in obese women as ramp exercise frequently underestimates VO2max in this population

Resistance to COVID-19 vaccination has increased in Ireland and the United Kingdom during the pandemic

Objectives: Hesitance and resistance to COVID-19 vaccination poses a serious challenge to achieving adequate vaccine uptake in the general population. Cross-sectional data from the early months of the pandemic indicates that approximately one-third of adults in multiple nations are hesitant or resistant to a vaccine for COVID-19. Using longitudinal data, we tracked changes in attitudes to COVID-19 vaccination during the pandemic. Study design: This is a quantitative, longitudinal design. Method: Nationally representative samples of the adult general population of the Republic of Ireland (N ¼ 1041) and the United Kingdom (N ¼ 2025) were assessed for their attitudes towards COVID-19 vaccination at three points from March to August 2020. Results: Statistically significant increases in resistance to COVID-19 vaccination were observed in Irish (from 9.5% to 18.1%) and British (from 6.2% to 10%) adults. Conclusion: Resistance to vaccination has significantly increased in two European nations as the pandemic has progressed. Growing resistance to COVID-19 vaccination will pose a challenge to public health officials responsible for ensuring sufficient vaccine coverag

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants

We recently mapped a genetic susceptibility locus on chromosome 6q22.33 for type 1 diabetes (T1D) diagnosed below the age of 7 years between the PTPRK and thymocyte-selection-associated (THEMIS) genes. As the thymus plays a central role in shaping the T cell repertoire, we aimed to identify the most likely causal genetic factors behind this association using thymocyte genomic data. In four thymocyte populations, we identified 253 DNA sequence motifs underlying histone modifications. The G insertion allele of rs138300818, associated with protection from diabetes, created thymocyte motifs for multiple histone modifications and thymocyte types. In a parallel approach to identifying variants that alter transcription factor binding motifs, the same variant disrupted a predicted motif for Rfx7, which is abundantly expressed in the thymus. Chromatin state and RNA sequencing data suggested strong transcription overlapping rs138300818 in fetal thymus, while expression quantitative trait locus and chromatin conformation data associate the insertion with lower THEMIS expression. Extending the analysis to other T1D loci further highlighted rs66733041 affecting the GATA3 transcription factor binding in the AFF3 locus. Taken together, our results support a role for thymic THEMIS gene expression and the rs138300818 variant in promoting the development of early-onset T1D.Peer reviewe