Modeling and analysis of single-molecule experiments

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.Vita.Includes bibliographical references (p. 281-311).Single molecule experiments offer a unique window into the molecular world. This window allows us to distinguish the behaviors of individual molecules from the behavior of bulk by observing rare events and heterogeneity in the dynamics. This thesis discusses both models for single molecule experiments, including the stretching of DNA in hydrodynamic flows and the diffusion of tracer particles in heterogeneous environments, and methods to analyze single molecule data to allow determination of properties and models for single molecule experiments. These methods of analysis are based on combining information theory and Bayesian methods with physical insight and are applied to several experimental situations.by James B. Witkoskie.Ph.D

Random Set Tracker Experiment on a Road Constrained Network with Resource Management

Abstract -This paper describes the application of finite set statistics (FISST) to real-time multiple target road constrained tracking problems. We studied specific test problems where multiple modality wireless sensor networks monitored road networks of interest. Acoustic and radar detections updated a global density that tracked the number and positions of targets. The global density determines "information states" that form the basis of a closed-loop Markov Decision Process resource management procedure that controls sensor operation